ES8604241A1 - Un procedimiento para la obtencion de acidos alquencarboxi- licos - Google Patents
Un procedimiento para la obtencion de acidos alquencarboxi- licosInfo
- Publication number
- ES8604241A1 ES8604241A1 ES544219A ES544219A ES8604241A1 ES 8604241 A1 ES8604241 A1 ES 8604241A1 ES 544219 A ES544219 A ES 544219A ES 544219 A ES544219 A ES 544219A ES 8604241 A1 ES8604241 A1 ES 8604241A1
- Authority
- ES
- Spain
- Prior art keywords
- opt
- alkyl
- substd
- aryl
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000543 intermediate Substances 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 13
- 125000003118 aryl group Chemical group 0.000 abstract 10
- 125000005843 halogen group Chemical group 0.000 abstract 7
- 229910052760 oxygen Inorganic materials 0.000 abstract 7
- 229910052717 sulfur Inorganic materials 0.000 abstract 7
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- BOXRDDIXJOUZLV-UHFFFAOYSA-N 2h-imidazo[4,5-d]thiadiazole Chemical compound N1SC2=NC=NC2=N1 BOXRDDIXJOUZLV-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000005956 isoquinolyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000002755 pyrazolinyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- -1 thienyl- pyrimidyl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS ALQUENCARBOXILICOS, DE FORMULA (I), EN LA QUE A, R1, R2, R3, R4 Y R5 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE COMPUESTOS CARBONILO, DE FORMULA (II), CON COMPUESTOS FOSFONATO, DE FORMULA (III), EN LAS QUE R14, R15 Y R16 PUEDEN SER VARIOS RADICALES Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE FUERTE, Y LOS DERIVADOS DE ACIDOS CARBOXILICOS OBTENIDOS SE SAPONIFICAN CON ACIDOS O LEJIAS PARA FORMAR LOS ACIDOS LIBRES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIHIPERTENSIVOS, DIURETICOS Y URICOSURICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3329621A DE3329621A1 (de) | 1983-08-17 | 1983-08-17 | Aminoalkyl-imidazothiadiazol-alkencarbonsaeureamide, neue zwischenprodukte zu ihrer herstellung, ihre herstellung und ihre verwendung in arzneimitteln |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8604241A1 true ES8604241A1 (es) | 1986-01-16 |
| ES544219A0 ES544219A0 (es) | 1986-01-16 |
Family
ID=6206712
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES535054A Expired ES8600768A1 (es) | 1983-08-17 | 1984-08-10 | Imidazotiadiazolalquencarboxiamidas |
| ES544218A Expired ES8604240A1 (es) | 1983-08-17 | 1985-06-14 | Un procedimiento para la obtencion de carbonil compuestos |
| ES544216A Expired ES8604238A1 (es) | 1983-08-17 | 1985-06-14 | Un procedimiento para la obtencion de imidazotiadiazolal- quen-carboxiamidas |
| ES544215A Expired ES8604237A1 (es) | 1983-08-17 | 1985-06-14 | Un procedimiento para la obtencion de imidazotiadiazolal- quen-carboxiamidas |
| ES544220A Expired ES8604242A1 (es) | 1983-08-17 | 1985-06-14 | Un procedimiento para la obtencion de acidos alquencarboxi- licos |
| ES544217A Expired ES8604239A1 (es) | 1983-08-17 | 1985-06-14 | Un procedimiento para la obtencion de imidazotiadiazolal- quen-carboxiamidas |
| ES544219A Expired ES8604241A1 (es) | 1983-08-17 | 1985-06-14 | Un procedimiento para la obtencion de acidos alquencarboxi- licos |
Family Applications Before (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES535054A Expired ES8600768A1 (es) | 1983-08-17 | 1984-08-10 | Imidazotiadiazolalquencarboxiamidas |
| ES544218A Expired ES8604240A1 (es) | 1983-08-17 | 1985-06-14 | Un procedimiento para la obtencion de carbonil compuestos |
| ES544216A Expired ES8604238A1 (es) | 1983-08-17 | 1985-06-14 | Un procedimiento para la obtencion de imidazotiadiazolal- quen-carboxiamidas |
| ES544215A Expired ES8604237A1 (es) | 1983-08-17 | 1985-06-14 | Un procedimiento para la obtencion de imidazotiadiazolal- quen-carboxiamidas |
| ES544220A Expired ES8604242A1 (es) | 1983-08-17 | 1985-06-14 | Un procedimiento para la obtencion de acidos alquencarboxi- licos |
| ES544217A Expired ES8604239A1 (es) | 1983-08-17 | 1985-06-14 | Un procedimiento para la obtencion de imidazotiadiazolal- quen-carboxiamidas |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4588723A (es) |
| EP (1) | EP0141072A3 (es) |
| JP (1) | JPS6058989A (es) |
| KR (1) | KR850001762A (es) |
| AU (1) | AU3111184A (es) |
| CA (1) | CA1234113A (es) |
| DE (1) | DE3329621A1 (es) |
| DK (1) | DK394384A (es) |
| ES (7) | ES8600768A1 (es) |
| FI (1) | FI843226A7 (es) |
| GR (1) | GR80133B (es) |
| HU (1) | HU190969B (es) |
| IL (1) | IL72678A0 (es) |
| NO (1) | NO843108L (es) |
| PT (1) | PT79084B (es) |
| ZA (1) | ZA846378B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3670080D1 (de) * | 1985-12-23 | 1990-05-10 | Zambeletti Spa L | Azacyclische verbindungen, verfahren zur ihrer herstellung und ihre verwendung als pharmazeutika. |
| DE102005010215A1 (de) * | 2005-03-05 | 2006-09-07 | Bayer Cropscience Ag | Heterobicyclische Acrylamide |
| EP2682395A1 (en) * | 2012-07-04 | 2014-01-08 | Laboratorios Del. Dr. Esteve, S.A. | Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444770A (en) * | 1980-05-29 | 1984-04-24 | Bayer Aktiengesellschaft | New imidazoazole-alkenoic acid amide compounds, intermediate products for their production, their production, and their medicinal use |
-
1983
- 1983-08-17 DE DE3329621A patent/DE3329621A1/de not_active Withdrawn
-
1984
- 1984-07-24 AU AU31111/84A patent/AU3111184A/en not_active Abandoned
- 1984-07-26 US US06/634,851 patent/US4588723A/en not_active Expired - Fee Related
- 1984-08-02 NO NO843108A patent/NO843108L/no unknown
- 1984-08-06 EP EP84109291A patent/EP0141072A3/de not_active Withdrawn
- 1984-08-10 ES ES535054A patent/ES8600768A1/es not_active Expired
- 1984-08-14 PT PT79084A patent/PT79084B/pt unknown
- 1984-08-14 IL IL72678A patent/IL72678A0/xx unknown
- 1984-08-15 FI FI843226A patent/FI843226A7/fi not_active Application Discontinuation
- 1984-08-15 CA CA000461031A patent/CA1234113A/en not_active Expired
- 1984-08-16 ZA ZA846378A patent/ZA846378B/xx unknown
- 1984-08-16 DK DK394384A patent/DK394384A/da not_active Application Discontinuation
- 1984-08-16 JP JP59170086A patent/JPS6058989A/ja active Pending
- 1984-08-16 HU HU843114A patent/HU190969B/hu unknown
- 1984-08-16 KR KR1019840004913A patent/KR850001762A/ko not_active Withdrawn
- 1984-08-17 GR GR80133A patent/GR80133B/el unknown
-
1985
- 1985-06-14 ES ES544218A patent/ES8604240A1/es not_active Expired
- 1985-06-14 ES ES544216A patent/ES8604238A1/es not_active Expired
- 1985-06-14 ES ES544215A patent/ES8604237A1/es not_active Expired
- 1985-06-14 ES ES544220A patent/ES8604242A1/es not_active Expired
- 1985-06-14 ES ES544217A patent/ES8604239A1/es not_active Expired
- 1985-06-14 ES ES544219A patent/ES8604241A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| PT79084A (en) | 1984-09-01 |
| ES8604239A1 (es) | 1986-01-16 |
| IL72678A0 (en) | 1984-11-30 |
| EP0141072A3 (de) | 1986-01-08 |
| ES544217A0 (es) | 1986-01-16 |
| HU190969B (en) | 1986-12-28 |
| GR80133B (en) | 1984-12-19 |
| DK394384A (da) | 1985-02-18 |
| ES544220A0 (es) | 1986-01-16 |
| FI843226A7 (fi) | 1985-02-18 |
| ES544218A0 (es) | 1986-01-16 |
| JPS6058989A (ja) | 1985-04-05 |
| ES8604238A1 (es) | 1986-01-16 |
| CA1234113A (en) | 1988-03-15 |
| ES8604237A1 (es) | 1986-01-16 |
| US4588723A (en) | 1986-05-13 |
| DE3329621A1 (de) | 1985-02-28 |
| ES8604240A1 (es) | 1986-01-16 |
| PT79084B (en) | 1986-08-14 |
| ES544219A0 (es) | 1986-01-16 |
| ES535054A0 (es) | 1985-10-16 |
| ES8604242A1 (es) | 1986-01-16 |
| AU3111184A (en) | 1985-02-21 |
| KR850001762A (ko) | 1985-04-01 |
| DK394384D0 (da) | 1984-08-16 |
| ES8600768A1 (es) | 1985-10-16 |
| ES544215A0 (es) | 1986-01-16 |
| NO843108L (no) | 1985-02-18 |
| FI843226A0 (fi) | 1984-08-15 |
| ZA846378B (en) | 1985-05-29 |
| HUT36130A (en) | 1985-08-28 |
| ES544216A0 (es) | 1986-01-16 |
| EP0141072A2 (de) | 1985-05-15 |
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