ES8603400A1 - Derivados de prostaglandina - Google Patents
Derivados de prostaglandinaInfo
- Publication number
- ES8603400A1 ES8603400A1 ES537613A ES537613A ES8603400A1 ES 8603400 A1 ES8603400 A1 ES 8603400A1 ES 537613 A ES537613 A ES 537613A ES 537613 A ES537613 A ES 537613A ES 8603400 A1 ES8603400 A1 ES 8603400A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- reaction
- compound
- derivatives
- prostaglandina
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PROSTAGLANDINA, DE FORMULA (I), EN LA QUE X, R1, R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN LAS QUE TODOS LOS SIMBOLOS TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UN BUTIL-LITIO Y DE HEXAMETILFOSFOROTRIAMIDA, A LA TEMPERATURA DE C60JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ULCERAS, PANCREATITIS, ENFERMEDADES DEL HIGADO TAL COMO LA CIRROSIS Y DE ESOFAGUITIS DE REFLUJO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/551,238 US4499296A (en) | 1983-11-14 | 1983-11-14 | Omega cycloalkyl prostaglandins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES537613A0 ES537613A0 (es) | 1985-12-16 |
| ES8603400A1 true ES8603400A1 (es) | 1985-12-16 |
Family
ID=24200423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES537613A Expired ES8603400A1 (es) | 1983-11-14 | 1984-11-13 | Derivados de prostaglandina |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4499296A (es) |
| EP (1) | EP0142158B1 (es) |
| JP (1) | JPS60116667A (es) |
| AT (1) | ATE39481T1 (es) |
| AU (1) | AU3536084A (es) |
| DE (1) | DE3475785D1 (es) |
| DK (1) | DK538984A (es) |
| ES (1) | ES8603400A1 (es) |
| FI (1) | FI844460A7 (es) |
| GR (1) | GR80926B (es) |
| IL (1) | IL73501A (es) |
| NO (1) | NO844528L (es) |
| NZ (1) | NZ210197A (es) |
| PH (1) | PH21604A (es) |
| PT (1) | PT79488A (es) |
| ZA (1) | ZA848840B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713477A (en) * | 1983-11-14 | 1987-12-15 | G. D. Searle & Co. | Omega cycloalkyl prostaglandins |
| GB8410396D0 (en) * | 1984-04-24 | 1984-05-31 | Glaxo Group Ltd | Carbocyclic compounds |
| DE3526362A1 (de) * | 1985-07-19 | 1987-01-22 | Schering Ag | Prostacycline, ihre analoga oder prostaglandine und thromboxanantagonisten zur behandlung von thrombotischen und thromboembolischen krankheitsbildern |
| EP0213313A3 (en) * | 1985-07-29 | 1988-09-14 | American Cyanamid Company | Precursors and synthesis of methyl-9-oxo-11 alpha, 16-dihydroxy-16-vinyl-5-cis-13-trans prostadienoates |
| US4820728A (en) * | 1985-11-25 | 1989-04-11 | G. D. Searle & Co. | Tetraenyl prostaglandins |
| US4683328A (en) * | 1985-11-25 | 1987-07-28 | G. D. Searle & Co. | Tetraenyl prostaglandins |
| US4847293A (en) * | 1985-11-25 | 1989-07-11 | G. D. Searle & Co. | Tetraenyl prostaglandins |
| US5011958A (en) * | 1987-06-08 | 1991-04-30 | G. D. Searle & Co. | Process for preparing higher order cuprate complexes |
| US4785124A (en) * | 1987-06-08 | 1988-11-15 | G. D. Searle & Co. | Process for preparing higher order cuprate complexes |
| US4777275A (en) * | 1987-06-09 | 1988-10-11 | G. D. Searle & Co. | Process of preparing higher order cuprate complexes |
| ATE117290T1 (de) * | 1990-02-26 | 1995-02-15 | R Tech Ueno Ltd | 15-dehydroxy-16-oxoprostaglandine. |
| US5177251A (en) * | 1991-12-24 | 1993-01-05 | G. D. Searle & Co. | Halogenated tetraenyl prostaglandin derivatives |
| JP2531341Y2 (ja) * | 1993-02-25 | 1997-04-02 | 小糸工業株式会社 | 衛生洗浄装置におけるワイヤレスリモコン装置 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3965143A (en) * | 1974-03-26 | 1976-06-22 | G. D. Searle & Co. | 16-Oxygenated prostanoic acid derivatives |
| US4281153A (en) * | 1977-08-01 | 1981-07-28 | American Cyanamid | 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners |
| US4275224A (en) * | 1978-02-23 | 1981-06-23 | Miles Laboratories, Inc. | 15-Deoxy-16-hydroxy prostaglandins |
| US4271314A (en) * | 1979-11-28 | 1981-06-02 | G. D. Searle & Co. | 4,5-Unsaturated prostanoic acid derivatives |
-
1983
- 1983-11-14 US US06/551,238 patent/US4499296A/en not_active Expired - Lifetime
-
1984
- 1984-11-13 JP JP59239323A patent/JPS60116667A/ja active Granted
- 1984-11-13 PT PT79488A patent/PT79488A/pt unknown
- 1984-11-13 EP EP84113676A patent/EP0142158B1/en not_active Expired
- 1984-11-13 ZA ZA848840A patent/ZA848840B/xx unknown
- 1984-11-13 NZ NZ210197A patent/NZ210197A/en unknown
- 1984-11-13 IL IL73501A patent/IL73501A/xx unknown
- 1984-11-13 AT AT84113676T patent/ATE39481T1/de not_active IP Right Cessation
- 1984-11-13 DK DK538984A patent/DK538984A/da not_active Application Discontinuation
- 1984-11-13 GR GR80926A patent/GR80926B/el unknown
- 1984-11-13 DE DE8484113676T patent/DE3475785D1/de not_active Expired
- 1984-11-13 NO NO844528A patent/NO844528L/no unknown
- 1984-11-13 ES ES537613A patent/ES8603400A1/es not_active Expired
- 1984-11-13 FI FI844460A patent/FI844460A7/fi not_active Application Discontinuation
- 1984-11-13 PH PH31444A patent/PH21604A/en unknown
- 1984-11-13 AU AU35360/84A patent/AU3536084A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO844528L (no) | 1985-05-15 |
| ES537613A0 (es) | 1985-12-16 |
| DK538984D0 (da) | 1984-11-13 |
| EP0142158B1 (en) | 1988-12-28 |
| FI844460L (fi) | 1985-05-15 |
| US4499296A (en) | 1985-02-12 |
| IL73501A (en) | 1987-12-31 |
| NZ210197A (en) | 1988-04-29 |
| FI844460A0 (fi) | 1984-11-13 |
| ZA848840B (en) | 1985-12-24 |
| AU3536084A (en) | 1985-05-23 |
| FI844460A7 (fi) | 1985-05-15 |
| DE3475785D1 (en) | 1989-02-02 |
| GR80926B (en) | 1985-02-26 |
| EP0142158A2 (en) | 1985-05-22 |
| EP0142158A3 (en) | 1986-09-03 |
| ATE39481T1 (de) | 1989-01-15 |
| DK538984A (da) | 1985-05-15 |
| PT79488A (en) | 1984-12-01 |
| JPS60116667A (ja) | 1985-06-24 |
| IL73501A0 (en) | 1985-02-28 |
| JPH0576467B2 (es) | 1993-10-22 |
| PH21604A (en) | 1987-12-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8304095A1 (es) | Un procedimiento para la preparacion de derivados de quinazolina. | |
| ES8603400A1 (es) | Derivados de prostaglandina | |
| ES8401044A1 (es) | Procedimiento para preparar derivados de piridona. | |
| ES8402273A1 (es) | Un procedimiento para la preparacion de 1,4-dihidropiridinas. | |
| ES8204428A1 (es) | Procedimiento para preparar alfa-aril-1h-1,2,4-triazol-1- etanoles | |
| ES8303383A1 (es) | Un procedimiento para la preparacion de derivados del 1,2,5-tiadiazol | |
| ES8402306A1 (es) | Un procedimiento para la preparacion de nuevos derivados de oxabicicloalcano. | |
| ES8306121A1 (es) | Procedimiento para la obtencion de derivados de imidazol trisustituidos. | |
| ES8106722A1 (es) | Un metodo para la preparacion de derivados de ftalimidina | |
| ES8305681A1 (es) | Procedimiento para la obtencion de fenileteres sustituidos. | |
| ES8303426A1 (es) | Un procedimiento para la preparacion de un compuesto de cefalosporina. | |
| ES8306750A1 (es) | Un procedimiento para la preparacion de 2-guanidino-4-heteroariltiazoles. | |
| ES8606879A1 (es) | Un procedimiento para la preparacion de derivados esteroida-les | |
| ES8300692A1 (es) | Un procedimiento para la preparacion de derivados de acido carbamico | |
| ES8301972A1 (es) | Procedimiento para la obtencion de n-oxidos de compuestos den-oxaciclil-alquil-piperidil-diaza | |
| ES8706654A1 (es) | Un procedimiento para la preparacion de nuevos derivados de benzotiazina | |
| ES8609323A1 (es) | Un procedimiento para la preparacion de hexahidro-arilquinolizinas sustituidas. | |
| ES8403437A1 (es) | Un procedimiento para obtener derivados de indanilbenzamida. | |
| ES8201116A1 (es) | Procedimiento para preparar derivados de 2-nitro-5-(fenoxi sustituido)-benzoilo | |
| ES8600730A1 (es) | Procedimiento para la preparacion de agentes anti-psoriaticos del tipo naftalenico | |
| ES8704503A1 (es) | Procedimiento para preparar sales de ciclimonio | |
| ES8607982A1 (es) | Un procedimiento para preparar un derivado de uridina | |
| ES8609246A1 (es) | Un procedimiento para preparar un derivado de 3-carbonil-1- aminoalquil-1h-indol | |
| ES8609327A1 (es) | Procedimiento para preparar derivados de imidazo (1,5-a)pi- rimidina | |
| ES8800193A1 (es) | Procedimiento para preparar 2,4-difenil-1,3-dioxanos |