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ES8601922A1 - Un procedimiento para preparar derivados de pirimidina - Google Patents

Un procedimiento para preparar derivados de pirimidina

Info

Publication number
ES8601922A1
ES8601922A1 ES538190A ES538190A ES8601922A1 ES 8601922 A1 ES8601922 A1 ES 8601922A1 ES 538190 A ES538190 A ES 538190A ES 538190 A ES538190 A ES 538190A ES 8601922 A1 ES8601922 A1 ES 8601922A1
Authority
ES
Spain
Prior art keywords
lower alkyl
formula
optionally substituted
alcoxy
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538190A
Other languages
English (en)
Other versions
ES538190A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838308290A external-priority patent/GB8308290D0/en
Priority claimed from GB838315542A external-priority patent/GB8315542D0/en
Priority claimed from GB838327859A external-priority patent/GB8327859D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES8601922A1 publication Critical patent/ES8601922A1/es
Publication of ES538190A0 publication Critical patent/ES538190A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE PIRIMIDINA.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) O SU DERIVADO REACTIVO EN EL GRUPO TIOXO Y UNA SAL DEL MISMO, CON UN COMPUESTO DE FORMULA R6-NH2 O SU SAL, PARA OBTENER DERIVADOS DE PIRIMIDINA DE FORMULA (I) DONDE: Z ES UN GRUPO SELECCIONADO ENTRE LAS FORMULAS (III), (IV) Y (V); R3 ES H, ARILO OPTATIVAMENTE SUSTITUIDO CON ALQUILO O INFERIOR, ALCOXI INFERIOR Y/O HALOGENO, O PIRIDILO OPTATIVAMENTE SUSTITUIDO CON ALQUILO INFERIOR; R4 ES H, ALQUILO INFERIOR O FENILO, OPTATIVAMENTE SUSTITUIDO CON ALCOXI INFERIOR; Y R6 ES ALQUILO INFERIOR, CICLO(ALQUILO INFERIOR), AR-(ALQUILO INFERIOR), OPTATIVAMENTE SUSTITUIDO CON ALCOXI INFERIOR, UN GRUPO HETEROCICLICO INSATURADO QUE CONTIENE N, OPTATIVAMENTE SUSTITUIDO CON ALQUILO INFERIOR U OTROS.TIENEN UTILIDAD FARMACEUTICA COMO CARDIOTONICOS, AGENTES ANTIHIPERTENSIVOS, VASODILATADORES CEREBROVASCULARES Y AGENTES ANTIPLAQUETAS.
ES538190A 1983-03-25 1984-11-30 Un procedimiento para preparar derivados de pirimidina Granted ES538190A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB838308290A GB8308290D0 (en) 1983-03-25 1983-03-25 Pyrimidinone derivatives
GB838315542A GB8315542D0 (en) 1983-06-07 1983-06-07 Pyrimidinone derivatives
GB838327859A GB8327859D0 (en) 1983-10-18 1983-10-18 Pyrimidine derivatives

Publications (2)

Publication Number Publication Date
ES8601922A1 true ES8601922A1 (es) 1985-11-01
ES538190A0 ES538190A0 (es) 1985-11-01

Family

ID=27262023

Family Applications (2)

Application Number Title Priority Date Filing Date
ES530916A Expired ES8505972A1 (es) 1983-03-25 1984-03-23 Un procedimiento para preparar derivados de pirimidina
ES538190A Granted ES538190A0 (es) 1983-03-25 1984-11-30 Un procedimiento para preparar derivados de pirimidina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES530916A Expired ES8505972A1 (es) 1983-03-25 1984-03-23 Un procedimiento para preparar derivados de pirimidina

Country Status (13)

Country Link
US (3) US4612376A (es)
EP (1) EP0123402B1 (es)
KR (1) KR840008333A (es)
CA (1) CA1256107A (es)
DE (1) DE3473875D1 (es)
DK (1) DK160492C (es)
ES (2) ES8505972A1 (es)
FI (1) FI841128A7 (es)
GR (1) GR81758B (es)
HU (1) HU195195B (es)
NO (1) NO841168L (es)
PH (1) PH22022A (es)
SU (2) SU1349698A3 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4612376A (en) * 1983-03-25 1986-09-16 Fujisawa Pharmaceutical Co., Ltd. Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent
US4598149A (en) * 1984-03-02 1986-07-01 Merck & Co., Inc. 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihypertensive, cardioprotective, antiarrythmic, and antianginal agents
US4649142A (en) * 1984-06-25 1987-03-10 Fujisawa Pharmaceutical Co., Ltd. 3,4-dihydro-1,3-disubstituted-6-(substituted phenylimino)-2(1H)-pyrimidinone useful as cardiotonic agent and anti-allergic agent
US4708958A (en) * 1986-09-24 1987-11-24 G. D. Searle & Co. 6-(imidazolyphenyl)-4-iminopyrimidinones useful as hypotensive agents
US5521315A (en) * 1993-01-12 1996-05-28 Cell Therapeutics, Inc. Olefin substituted long chain compounds
IT1270122B (it) * 1994-10-04 1997-04-28 Ist Superiore Sanita 6-benzil-4-ossopirimidine sostituite, processo per la loro preparazione e composizioni farmaceutiche che le contengono
RU2170734C2 (ru) * 1995-09-06 2001-07-20 Кова Ко., Лтд. Производные пиримидина, фармацевтическая композиция и способ профилактики и лечения болезни
US6244121B1 (en) * 1998-03-06 2001-06-12 Applied Materials, Inc. Sensor device for non-intrusive diagnosis of a semiconductor processing system
CN102558155A (zh) 2003-01-14 2012-07-11 阿伦纳药品公司 作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗
AU2004257267B2 (en) 2003-07-14 2009-12-03 Arena Pharmaceuticals,Inc Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
DOP2006000009A (es) 2005-01-13 2006-08-15 Arena Pharm Inc Procedimiento para preparar eteres de pirazolo [3,4-d] pirimidina
EP1924262B1 (en) 2005-08-22 2011-11-16 Melior Pharmaceuticals I, Inc. Methods and formulations for modulating lyn kinase activity and treating related disorders
KR20100014480A (ko) * 2007-02-20 2010-02-10 멜리어 파마슈티칼스 아이, 인코포레이티드 Ｌｙｎ 키나제 활성제의 확인 방법
AU2008279242A1 (en) * 2007-07-23 2009-01-29 Melior Discovery, Inc. Methods of activating IRS-1 and AKT
US8552184B2 (en) * 2008-07-03 2013-10-08 Melior Pharmaceuticals I, Inc. Compounds and methods for treating disorders related to glucose metabolism
EP2462123B1 (en) * 2009-08-04 2013-10-02 Merck Sharp & Dohme Corp. 4,5,6-trisubstituted pyrimidine derivatives as factor ixa inhibitors
EP4148045A1 (en) 2010-01-27 2023-03-15 Arena Pharmaceuticals, Inc. Intermediate compounds for the preparation of (r)-2-(7-(4-cyclopentyl-3- (trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b] indol-3-yl)acetic acid and salts thereof
US20130158055A1 (en) 2010-05-28 2013-06-20 Andrew G. Reaume Prevention Of Pancreatic Beta Cell Degeneration
EA201390421A1 (ru) 2010-09-22 2013-09-30 Арена Фармасьютикалз, Инк. Модуляторы рецептора gpr119 и лечение связанных с ним нарушений
JP6632532B2 (ja) * 2014-08-29 2020-01-22 国立大学法人 東京大学 オートタキシン阻害活性を有するピリミジノン誘導体
US10183949B2 (en) 2014-08-29 2019-01-22 The University Of Tokyo Pyrimidinone derivative having autotaxin-inhibitory activity
EP4445956A3 (en) 2015-01-06 2024-12-04 Arena Pharmaceuticals, Inc. Compound for use in treating conditions related to the s1p1 receptor
PL3310760T3 (pl) 2015-06-22 2023-03-06 Arena Pharmaceuticals, Inc. Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
CN110520124A (zh) 2017-02-16 2019-11-29 艾尼纳制药公司 用于治疗原发性胆汁性胆管炎的化合物和方法
KR102634575B1 (ko) 2017-04-10 2024-02-06 멜리어 파마슈티칼스 아이, 인코포레이티드 지방세포의 처리
CA3102136A1 (en) 2018-06-06 2019-12-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
CN109053589A (zh) * 2018-09-30 2018-12-21 浙江师范大学 4-亚胺基四氢嘧啶-2-酮类化合物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1296371A (es) * 1969-02-26 1972-11-15
AU1108070A (en) * 1969-03-06 1971-08-12 Imperial Chemical Industries Limited Pyrimidine derivatives
GB1336138A (en) * 1969-12-10 1973-11-07 Ici Ltd Process for the production of pyrimidine derivatives
US3923807A (en) * 1973-09-10 1975-12-02 Takeda Chemical Industries Ltd 6-Aminouracil derivatives
US4208366A (en) * 1978-10-31 1980-06-17 E. I. Du Pont De Nemours And Company Process for preparing a nonwoven web
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
US4612376A (en) * 1983-03-25 1986-09-16 Fujisawa Pharmaceutical Co., Ltd. Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent

Also Published As

Publication number Publication date
FI841128A0 (fi) 1984-03-21
DK166884A (da) 1984-09-26
KR840008333A (ko) 1984-12-14
PH22022A (en) 1988-05-13
SU1436872A3 (ru) 1988-11-07
FI841128A7 (fi) 1984-09-26
NO841168L (no) 1984-09-26
CA1256107A (en) 1989-06-20
DK160492B (da) 1991-03-18
DK166884D0 (da) 1984-03-23
EP0123402B1 (en) 1988-09-07
SU1349698A3 (ru) 1987-10-30
ES530916A0 (es) 1985-06-16
ES8505972A1 (es) 1985-06-16
GR81758B (es) 1984-12-12
EP0123402A2 (en) 1984-10-31
US4824851A (en) 1989-04-25
EP0123402A3 (en) 1985-09-18
HU195195B (en) 1988-04-28
DE3473875D1 (en) 1988-10-13
ES538190A0 (es) 1985-11-01
US4746664A (en) 1988-05-24
US4612376A (en) 1986-09-16
DK160492C (da) 1991-08-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603