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ES8600323A1 - Un procedimiento para obtener 2-(2,3,5-tri-o-aril-b-d-ribofuranosil)selenazol-4-carboxilatos de alcohilo o aralcohilo - Google Patents

Un procedimiento para obtener 2-(2,3,5-tri-o-aril-b-d-ribofuranosil)selenazol-4-carboxilatos de alcohilo o aralcohilo

Info

Publication number
ES8600323A1
ES8600323A1 ES527279A ES527279A ES8600323A1 ES 8600323 A1 ES8600323 A1 ES 8600323A1 ES 527279 A ES527279 A ES 527279A ES 527279 A ES527279 A ES 527279A ES 8600323 A1 ES8600323 A1 ES 8600323A1
Authority
ES
Spain
Prior art keywords
aralcohyl
selenazol
alcohyl
tri
ribofuranosil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527279A
Other languages
English (en)
Other versions
ES527279A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham Young University
Original Assignee
Brigham Young University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham Young University filed Critical Brigham Young University
Publication of ES8600323A1 publication Critical patent/ES8600323A1/es
Publication of ES527279A0 publication Critical patent/ES527279A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D421/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms
    • C07D421/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings
    • C07D421/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA OBTENER 2-(2,3,5-TRI-O-ACIL-BBB-D-RIBOFURANOSIL) SELENAZOL-4-CARBOXILATOS DE ALCOHILO O ARALCOHILO.COMPRENDE CICLISAR 2,5-ANHIDRO-3,4,6-TRI-O-ACIL-D-ALONSELENOCARBOXAMIDA DE LA ESTRUCTURA DE FORMULA (I) EN DONDE Z ES -C(NH2)SE, CON UN BROMOPIRUVATO DE ALCOHILO O ARALCOHILO, LLEVANDOSE A CABO LA REACCION EN FRIO EN UN DISOLVENTE ADECUADO COMO ACETONITRILO O UN ALCOHOL DE BAJO PUNTO DE EBULLICION, PARA OBTENER 2-(2,3,5-TRI-O-ACIL-BBB-D-RIBOFURANOSIL) SELENAZOL-4-CARBOXILATOS DE ALCOHILO O ARALCOHILO DE LA ESTRUCTURA DE FORMULA (I), EN DONDE R1, R2 Y R3 SON CADA UNO DE ELLOS UN GRUPO ACILO Y Z ES UN GRUPO SELENAZOL-4-(ALCOHIL O ARALCOHIL) CARBOXILATO-2-ILO.TIENEN APLICACIONES FARMACEUTICAS POR SU ACTIVIDAD ANTITUMORAL Y ANTIVIRAL.
ES527279A 1982-03-23 1983-11-15 Un procedimiento para obtener 2-(2,3,5-tri-o-aril-b-d-ribofuranosil)selenazol-4-carboxilatos de alcohilo o aralcohilo Granted ES527279A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36096882A 1982-03-23 1982-03-23
US06/465,221 US4531001A (en) 1982-03-23 1983-02-15 2-β-D-ribofuranosylselenazole-4-carboxamide compounds

Publications (2)

Publication Number Publication Date
ES8600323A1 true ES8600323A1 (es) 1985-10-01
ES527279A0 ES527279A0 (es) 1985-10-01

Family

ID=27001098

Family Applications (5)

Application Number Title Priority Date Filing Date
ES520826A Expired ES8404373A1 (es) 1982-03-23 1983-03-22 Un procedimiento para obtener compuestos de ribofuranosilselenazol-4-carboxamida.
ES527279A Granted ES527279A0 (es) 1982-03-23 1983-11-15 Un procedimiento para obtener 2-(2,3,5-tri-o-aril-b-d-ribofuranosil)selenazol-4-carboxilatos de alcohilo o aralcohilo
ES527278A Granted ES527278A0 (es) 1982-03-23 1983-11-15 Un procedimiento para obtener 2,5-anhidro-3,4,6-tri-o-acil-d-alonselenocarboxamida
ES527277A Expired ES8600322A1 (es) 1982-03-23 1983-11-15 Un procedimiento para obtener compuestos de 2'-o-acil-, 3'-o-acil-, 2',3'-di-o-acil- y 2',3',5'-tri-o-acil-2-b-d-ribofuranosilselenazol-4-carboxamida
ES527276A Granted ES527276A0 (es) 1982-03-23 1983-11-15 Un procedimiento para obtener compuestos de ribofuranosilselenazol-4-carboxamida-5'-fosfato

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES520826A Expired ES8404373A1 (es) 1982-03-23 1983-03-22 Un procedimiento para obtener compuestos de ribofuranosilselenazol-4-carboxamida.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES527278A Granted ES527278A0 (es) 1982-03-23 1983-11-15 Un procedimiento para obtener 2,5-anhidro-3,4,6-tri-o-acil-d-alonselenocarboxamida
ES527277A Expired ES8600322A1 (es) 1982-03-23 1983-11-15 Un procedimiento para obtener compuestos de 2'-o-acil-, 3'-o-acil-, 2',3'-di-o-acil- y 2',3',5'-tri-o-acil-2-b-d-ribofuranosilselenazol-4-carboxamida
ES527276A Granted ES527276A0 (es) 1982-03-23 1983-11-15 Un procedimiento para obtener compuestos de ribofuranosilselenazol-4-carboxamida-5'-fosfato

Country Status (14)

Country Link
US (1) US4531001A (es)
EP (1) EP0089678B1 (es)
KR (1) KR880001869B1 (es)
AU (1) AU553665B2 (es)
CA (1) CA1209986A (es)
DE (1) DE3366378D1 (es)
DK (2) DK167765B1 (es)
ES (5) ES8404373A1 (es)
FI (1) FI76574C (es)
GR (1) GR78301B (es)
IE (1) IE54520B1 (es)
NO (1) NO155842C (es)
NZ (1) NZ203649A (es)
PT (1) PT76426B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619996A (en) * 1984-07-09 1986-10-28 Warner-Lambert Company Process for preparing 2-β-D-ribofuranosylselenazole-4-carboxamide
US4801698A (en) * 1986-08-15 1989-01-31 Warner-Lambert Company Process for preparing diaminopyrimido(4,5-d)pyrimidine glycoside and glycotide
US5438131A (en) * 1992-09-16 1995-08-01 Bergstrom; Donald E. 3-nitropyrrole nucleoside
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
AU5298096A (en) * 1995-02-17 1996-09-11 Icn Pharmaceuticals, Inc. Procedures for obtaining ribo-c-nucleosides
UA63956C2 (uk) * 1997-06-30 2004-02-16 Ай-Сі-Ен Фармасьютикалз, Інк. Спосіб одержання нуклеозидів
CN1166651C (zh) * 2001-06-08 2004-09-15 北京大学药学院 具有抗炎和抗肿瘤作用r-双或糖苯丙异硒唑取代化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3423399A (en) * 1966-06-09 1969-01-21 Takeda Chemical Industries Ltd Method for the production of 5'-ribonucleotide
US3798209A (en) * 1971-06-01 1974-03-19 Icn Pharmaceuticals 1,2,4-triazole nucleosides
US3984396A (en) * 1971-06-01 1976-10-05 Icn Pharmaceuticals, Inc. 1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters

Also Published As

Publication number Publication date
FI830941L (fi) 1983-09-24
KR840004126A (ko) 1984-10-06
GR78301B (es) 1984-09-26
DK25093D0 (da) 1993-03-08
ES520826A0 (es) 1984-05-01
FI830941A0 (fi) 1983-03-22
FI76574C (fi) 1988-11-10
ES527277A0 (es) 1985-10-01
DK172165B1 (da) 1997-12-08
EP0089678B1 (en) 1986-09-24
NO831012L (no) 1983-09-26
IE54520B1 (en) 1989-11-08
ES8504795A1 (es) 1985-04-16
ES527279A0 (es) 1985-10-01
ES8404373A1 (es) 1984-05-01
PT76426A (en) 1983-04-01
DK25093A (da) 1993-03-08
FI76574B (fi) 1988-07-29
ES8600321A1 (es) 1985-10-01
DK129983A (da) 1983-09-24
EP0089678A1 (en) 1983-09-28
ES527278A0 (es) 1985-04-16
AU553665B2 (en) 1986-07-24
AU1269383A (en) 1983-09-29
ES527276A0 (es) 1985-10-01
DE3366378D1 (en) 1986-10-30
NO155842C (no) 1987-06-10
ES8600322A1 (es) 1985-10-01
CA1209986A (en) 1986-08-19
US4531001A (en) 1985-07-23
PT76426B (en) 1986-02-04
IE830580L (en) 1983-09-23
DK129983D0 (da) 1983-03-22
NO155842B (no) 1987-03-02
KR880001869B1 (ko) 1988-09-23
NZ203649A (en) 1985-02-28
DK167765B1 (da) 1993-12-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040614