[go: up one dir, main page]

ES8600229A1 - Procedimiento para preparar nuevos bis-(piperazinil- u homopiperazinil)-alcanos - Google Patents

Procedimiento para preparar nuevos bis-(piperazinil- u homopiperazinil)-alcanos

Info

Publication number
ES8600229A1
ES8600229A1 ES535439A ES535439A ES8600229A1 ES 8600229 A1 ES8600229 A1 ES 8600229A1 ES 535439 A ES535439 A ES 535439A ES 535439 A ES535439 A ES 535439A ES 8600229 A1 ES8600229 A1 ES 8600229A1
Authority
ES
Spain
Prior art keywords
formula
bis
valen
compound
homopiperazinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535439A
Other languages
English (en)
Other versions
ES535439A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Corp
Original Assignee
Boehringer Ingelheim Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Corp filed Critical Boehringer Ingelheim Corp
Publication of ES535439A0 publication Critical patent/ES535439A0/es
Publication of ES8600229A1 publication Critical patent/ES8600229A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE BIS-(PIPERAZINIL- U HOMOPIPERAZINIL)-ALCANOS Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1-R16 PUEDEN SER VARIOS RADICALES, X ES ALQUILENO C1-2; A ES -CH2-; J Y N VALEN 0-3; Y K Y M VALEN DISTINTO DE CERO.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN LAS QUE Y ES UN GRUPO REACTIVO, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I).ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIALERGICOS Y ANTIINFLAMATORIOS.
ES535439A 1983-03-21 1984-08-27 Procedimiento para preparar nuevos bis-(piperazinil- u homopiperazinil)-alcanos Expired ES8600229A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47700883A 1983-03-21 1983-03-21

Publications (2)

Publication Number Publication Date
ES535439A0 ES535439A0 (es) 1985-09-16
ES8600229A1 true ES8600229A1 (es) 1985-09-16

Family

ID=23894132

Family Applications (4)

Application Number Title Priority Date Filing Date
ES530762A Expired ES8505992A1 (es) 1983-03-21 1984-03-20 Procedimiento para preparar nuevos bis-(piperazinil-u homopiperazinil)-alcanos
ES535439A Expired ES8600229A1 (es) 1983-03-21 1984-08-27 Procedimiento para preparar nuevos bis-(piperazinil- u homopiperazinil)-alcanos
ES535438A Granted ES535438A0 (es) 1983-03-21 1984-08-27 Procedimiento para preparar nuevos bis-(piperazinil- u homopiperazinil)-alcanos
ES535440A Expired ES8600230A1 (es) 1983-03-21 1984-08-27 Procedimiento para preparar nuevos bis-(piperazinil- u homopiperazinil)-alcanos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES530762A Expired ES8505992A1 (es) 1983-03-21 1984-03-20 Procedimiento para preparar nuevos bis-(piperazinil-u homopiperazinil)-alcanos

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES535438A Granted ES535438A0 (es) 1983-03-21 1984-08-27 Procedimiento para preparar nuevos bis-(piperazinil- u homopiperazinil)-alcanos
ES535440A Expired ES8600230A1 (es) 1983-03-21 1984-08-27 Procedimiento para preparar nuevos bis-(piperazinil- u homopiperazinil)-alcanos

Country Status (24)

Country Link
EP (1) EP0122488B1 (es)
JP (1) JPS59176265A (es)
KR (1) KR890000487B1 (es)
AT (1) ATE43843T1 (es)
AU (1) AU568122B2 (es)
CA (1) CA1218652A (es)
CS (1) CS254971B2 (es)
DD (1) DD219642A5 (es)
DE (1) DE3478601D1 (es)
DK (1) DK166022C (es)
ES (4) ES8505992A1 (es)
FI (1) FI80269C (es)
GR (1) GR81827B (es)
HU (1) HU191599B (es)
IE (1) IE57136B1 (es)
IL (1) IL71291A (es)
NO (1) NO162907C (es)
NZ (1) NZ207554A (es)
PH (1) PH25216A (es)
PL (2) PL252632A1 (es)
PT (1) PT78278B (es)
SU (2) SU1574174A3 (es)
YU (2) YU45598B (es)
ZA (1) ZA842037B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692448A (en) * 1984-11-20 1987-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Bis(arylpiperazinyl)sulfur compounds
JPS645287Y2 (es) * 1984-11-20 1989-02-09
CA2180190A1 (en) * 1995-07-10 1997-01-11 Kazumi Ogata Benzylpiperazine derivatives
RU2220140C2 (ru) * 1998-02-19 2003-12-27 Кова Ко., Лтд. Производное циклических амидов, фармацевтическая композиция и лекарственное средство, его содержащее, и способ лечения аллергического заболевания
US6897305B2 (en) * 1998-06-08 2005-05-24 Theravance, Inc. Calcium channel drugs and uses
US7101909B2 (en) 1998-10-12 2006-09-05 Theravance, Inc. Calcium channel drugs and uses
DE60023878T2 (de) 1999-05-18 2006-07-20 Teijin Ltd. Heilmittel und vorbeugung für mit chemokinen verbundenen erkrankungen
KR100667645B1 (ko) * 1999-08-04 2007-02-28 데이진 가부시키가이샤 환상 아민 ｃｃｒ3 길항제
US6849621B2 (en) * 2001-03-13 2005-02-01 Schering Corporation Piperidine compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA675224A (en) * 1963-12-03 Gabler Rudolf Piperazine derivatives
JPS5914032B2 (ja) * 1976-04-09 1984-04-02 日本新薬株式会社 ビストリメトキシベンジルピペラジノアルカン類
US4692448A (en) * 1984-11-20 1987-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Bis(arylpiperazinyl)sulfur compounds

Also Published As

Publication number Publication date
YU48284A (en) 1987-10-31
DK166022B (da) 1993-03-01
SU1568887A3 (ru) 1990-05-30
HU191599B (en) 1987-03-30
ES535439A0 (es) 1985-09-16
NO162907B (no) 1989-11-27
DE3478601D1 (de) 1989-07-13
GR81827B (es) 1984-12-12
ES530762A0 (es) 1985-06-16
FI80269C (fi) 1990-05-10
YU45598B (sh) 1992-07-20
KR890000487B1 (ko) 1989-03-18
DK166022C (da) 1993-08-02
PL141127B1 (en) 1987-06-30
NO841078L (no) 1984-09-24
AU2589184A (en) 1984-09-27
NZ207554A (en) 1987-03-31
SU1574174A3 (ru) 1990-06-23
PL246774A1 (en) 1985-07-30
FI841081A7 (fi) 1984-09-22
ES8600228A1 (es) 1985-09-16
CS254971B2 (en) 1988-02-15
DK160184D0 (da) 1984-03-20
NO162907C (no) 1990-03-07
IL71291A (en) 1987-11-30
ZA842037B (en) 1985-12-24
FI841081A0 (fi) 1984-03-19
CS196084A2 (en) 1987-07-16
DD219642A5 (de) 1985-03-13
YU107286A (en) 1987-10-31
KR840008007A (ko) 1984-12-12
ATE43843T1 (de) 1989-06-15
AU568122B2 (en) 1987-12-17
IL71291A0 (en) 1984-06-29
CA1218652A (en) 1987-03-03
IE57136B1 (en) 1992-05-06
PT78278A (de) 1984-04-01
ES535438A0 (es) 1985-09-16
FI80269B (fi) 1990-01-31
ES535440A0 (es) 1985-09-16
ES8600230A1 (es) 1985-09-16
ES8505992A1 (es) 1985-06-16
JPS59176265A (ja) 1984-10-05
PT78278B (de) 1986-08-08
DK160184A (da) 1984-09-22
HUT34016A (en) 1985-01-28
IE840682L (en) 1984-09-21
EP0122488A1 (de) 1984-10-24
PL252632A1 (en) 1986-01-14
PH25216A (en) 1991-03-27
EP0122488B1 (de) 1989-06-07

Similar Documents

Publication Publication Date Title
ES8504128A1 (es) Procedimiento de preparar compuestos antiinflamatorios y anti-alergicos
ES8303386A1 (es) "un procedimiento para preparar acidos y esteres aminociclopentano-alquenoicos".
ES8303382A1 (es) Un procedimiento para la preparacion de derivados del 1,2,5-tiadiazol.
ES8306122A1 (es) Procedimiento para la obtencion de derivados de imidazol trisustituidos.
ES8404184A1 (es) Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
ES8600229A1 (es) Procedimiento para preparar nuevos bis-(piperazinil- u homopiperazinil)-alcanos
ES8607299A1 (es) Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimida- zo(2,1-b)quinazolinil)-oxialquilamidas
ATE26462T1 (de) Fluessige detergenszusammensetzung.
ES2034221T3 (es) Agentes antialergicos y antiinflamatorios de dihidropiridina.
ES8306483A1 (es) Procedimiento de preparacion de las dibezooxepinas sustituidas y de sus sales de adicion con un acido mineral u organico
ES8404317A1 (es) Metodo de preparar aminoaminoacidos y analogos.
ES8304537A1 (es) "procedimiento para la preparacion de nuevas fenilalcohilaminas".
ES8303427A1 (es) "un procedimiento para preparar compuestos de cefem".
ES8604557A1 (es) Un procedimiento para la preparacion de derivados de benzo- tiofeno
ES8406424A1 (es) Procedimiento para preparar derivados de guanidina.
FR2355822A1 (fr) Derives d'esters de l'acide indolacetique. utiles comme anti-inflammatoires et analgesiques
ES8303398A1 (es) Un procedimiento para la preparacion de un derivado de 2-piridincarboxamida.
ES8506270A1 (es) Un procedimiento para preparar compuestos analogos de la 7-oxabicicloheptano-prostaglandina
ES8300332A1 (es) Un procedimiento para la preparacion de nuevos derivados de imidazoquinazolinas
ES8504792A1 (es) Un procedimiento para preparar derivados de pirimidina
ES8300667A1 (es) Mejoras introducidas en un procedimiento de preparacion de un bifenil-2-carboxaldehido
ES8507527A1 (es) Procedimiento para producir derivados de tiatriazina
ATE15029T1 (de) Neue prostacyclin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel.
ES8300722A1 (es) Procedimiento para la preparacion de carbamoiloxiamino-1,4- benzodiazepinas
ES8301957A1 (es) Procedimiento para la obtencion de nuevas uniones hterociclicas que presentan analogias con la prostaciclina.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612