ES8600217A1 - Un procedimiento para producir peptidos que influyen en la funcion de la glandula pituitaria - Google Patents
Un procedimiento para producir peptidos que influyen en la funcion de la glandula pituitariaInfo
- Publication number
- ES8600217A1 ES8600217A1 ES535846A ES535846A ES8600217A1 ES 8600217 A1 ES8600217 A1 ES 8600217A1 ES 535846 A ES535846 A ES 535846A ES 535846 A ES535846 A ES 535846A ES 8600217 A1 ES8600217 A1 ES 8600217A1
- Authority
- ES
- Spain
- Prior art keywords
- leu
- arg
- ala
- ser
- gln
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Phe Chemical compound 0.000 abstract 4
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Chemical group OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 3
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical group OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 abstract 3
- ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical group CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 3
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical group C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 2
- WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 abstract 2
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 abstract 2
- 230000002267 hypothalamic effect Effects 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- DCXYFEDJOCDNAF-UWTATZPHSA-N D-Asparagine Chemical group OC(=O)[C@H](N)CC(N)=O DCXYFEDJOCDNAF-UWTATZPHSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical group OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
- SGCGMORCWLEJNZ-UWVGGRQHSA-N His-His Chemical compound C([C@H]([NH3+])C(=O)N[C@@H](CC=1NC=NC=1)C([O-])=O)C1=CN=CN1 SGCGMORCWLEJNZ-UWVGGRQHSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical group OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- 125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 abstract 1
- 125000000773 L-serino group Chemical group [H]OC(=O)[C@@]([H])(N([H])*)C([H])([H])O[H] 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000007515 enzymatic degradation Effects 0.000 abstract 1
- 230000001817 pituitary effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polymers & Plastics (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Husbandry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE PEPTIDOS QUE INFLUYEN EN LA FUNCION DE LA GLANDULA PITUITARIA, DE FORMULA (I), EN LA QUE LOS DIFERENTES RADICALES REPRESENTAN VARIOS RESTOS AMINOACIDOS.CONSISTE EN LA FORMACION DE UN COMPUESTO QUE TIENE AL MENOS UN GRUPO PROTECTOR Y LA FORMULA (II) X Y X1 C X8 SON HIDROGENO O UN GRUPO PROTECTOR Y X9 ES AMIDA, HIDROXILO O GRUPO PROTECTOR; SEGUIDA DE LA SEPARACION DEL GRUPO O GRUPOS PROTECTORES, DE MODO QUE SE FORMA EL COMPUESTO DE FORMULA (I) O UN FRAGMENTO BIOLOGICAMENTE ACTIVO DEL MISMO; Y, FINALMENTE, EVENTUAL FORMACION DE UNA SAL DE ADICION, NO TOXICA DE DICHO PEPTIDO.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS Y EN VETERINARIA PARA ESTIMULAR LA LIBERACION DE LA HORMONA DEL CRECIMIENTO, ASI COMO EN LA ESTIMULACION DE PROCESOS ANABOLICOS DESPUES DE QUEMADURAS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53217083A | 1983-09-13 | 1983-09-13 | |
| US06/545,094 US4518586A (en) | 1983-01-13 | 1983-10-25 | GRF Analogs III |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8600217A1 true ES8600217A1 (es) | 1985-10-01 |
| ES535846A0 ES535846A0 (es) | 1985-10-01 |
Family
ID=27063766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES535846A Granted ES535846A0 (es) | 1983-09-13 | 1984-09-12 | Un procedimiento para producir peptidos que influyen en la funcion de la glandula pituitaria |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4518586A (es) |
| EP (1) | EP0146210B1 (es) |
| JP (1) | JPH0689035B2 (es) |
| AU (1) | AU577057B2 (es) |
| CA (1) | CA1271599A (es) |
| DE (1) | DE3462603D1 (es) |
| DK (1) | DK165749C (es) |
| ES (1) | ES535846A0 (es) |
| FI (1) | FI88402C (es) |
| GR (1) | GR80335B (es) |
| HU (1) | HU200192B (es) |
| IE (1) | IE57774B1 (es) |
| IL (1) | IL72799A (es) |
| IN (1) | IN160247B (es) |
| MX (1) | MX161018A (es) |
| NO (1) | NO166944C (es) |
| NZ (1) | NZ209515A (es) |
| PH (1) | PH22310A (es) |
| PT (1) | PT79189B (es) |
| SU (1) | SU1435157A3 (es) |
| YU (1) | YU45968B (es) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4728726A (en) * | 1982-10-04 | 1988-03-01 | The Salk Institute For Biological Studies | GRF analogs IIIb |
| AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
| US4626523A (en) * | 1983-09-13 | 1986-12-02 | The Salk Institute For Biological Studies | GRF analogs II |
| US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
| US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
| US4649131A (en) * | 1984-09-24 | 1987-03-10 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| CA1271600A (en) * | 1985-01-07 | 1990-07-10 | David Howard Coy | Growth hormone-releasing peptides and method of treating mammals therewith |
| EP0193910A3 (en) * | 1985-03-06 | 1988-11-23 | Sumitomo Pharmaceuticals Company, Limited | Synthesis of a derivative of grf and intermediate peptides |
| US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| DK382886A (da) * | 1985-08-12 | 1987-02-13 | Syntex Inc | Fremgangsmaade til fremstilling af hormonfaktorderivater |
| US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
| US4870054A (en) * | 1985-09-27 | 1989-09-26 | Recker Robert R | Treatment for osteoporosis using GRF or a biologically active analog thereof |
| US4880778A (en) * | 1986-05-12 | 1989-11-14 | Eastman Kodak Company | Combinations having synergistic growth hormone releasing activity and methods for use thereof |
| IL84758A (en) * | 1987-01-13 | 1992-03-29 | Salk Inst For Biological Studi | Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them |
| IL86102A (en) * | 1987-05-11 | 1994-04-12 | Univ Tulane | Alkylated growth hormone-releasing peptides and use thereof |
| US5002931A (en) * | 1987-05-22 | 1991-03-26 | The Salk Institute For Biological Studies | GRF analogs VII |
| US4839344A (en) * | 1987-06-12 | 1989-06-13 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| USRE33699E (en) * | 1987-07-09 | 1991-09-24 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
| US4801456A (en) * | 1987-07-09 | 1989-01-31 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
| US4880777A (en) * | 1987-09-01 | 1989-11-14 | Eastman Kodak Company | Synthetic peptides having growth hormone releasing activity |
| AU637316B2 (en) * | 1988-01-28 | 1993-05-27 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| US5043322A (en) * | 1988-07-22 | 1991-08-27 | The Salk Institute For Biological Studies | Cyclic GRF analogs |
| US5023322A (en) * | 1988-08-31 | 1991-06-11 | Mta Kutatas-Es Szervezetelemzo Intezete | Analogs of growth hormone releasing factor (GRF) and a method for the preparation thereof |
| US5756458A (en) * | 1989-06-16 | 1998-05-26 | Pharmacia & Upjohn Company | Stabilized potent GRF analogs |
| IL98638A (en) * | 1990-06-29 | 1995-07-31 | Hoffmann La Roche | Analogs of the factor that releases human growth hormone, their preparation and pharmaceutical preparations that contain them |
| DE69108192T2 (de) * | 1990-12-10 | 1995-07-20 | Hoffmann La Roche | Verfahren zur enzymatischen Herstellung von GRF(1-44)NH2. |
| JPH05507939A (ja) * | 1991-04-09 | 1993-11-11 | エフ・ホフマン―ラ ロシユ アーゲー | 成長ホルモン放出因子の類似体 |
| US5246920A (en) * | 1992-06-15 | 1993-09-21 | University Of South Florida | Treatment of hyperprolactinemia |
| US5811074A (en) * | 1992-06-29 | 1998-09-22 | University Of South Florida | Method of diagnosing pituitary dependent growth hormone deficiency |
| US5550212A (en) * | 1993-12-17 | 1996-08-27 | The Administrators Of The Tulane Educational Fund | Analogues of hGH-RH(1-29)NH2 having antagonistic activity |
| EP1826216A1 (en) * | 1996-08-30 | 2007-08-29 | Novo Nordisk A/S | Glp-1 derivatives |
| BR0206919A (pt) * | 2001-02-02 | 2004-07-06 | Conjuchem Inc | Derivados de fator de liberação de hormÈnio de crescimento de longa duração |
| EP1539959A2 (en) * | 2002-09-18 | 2005-06-15 | Centre Hospitalier de l'Université de Montréal (CHUM) | Ghrh analogues |
| DK2118123T3 (en) | 2007-01-31 | 2016-01-25 | Dana Farber Cancer Inst Inc | Stabilized p53 peptides and uses thereof |
| KR101623985B1 (ko) | 2007-03-28 | 2016-05-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
| US20090088380A1 (en) * | 2007-07-12 | 2009-04-02 | Pierrette Gaudreau | Ghrh analogs and therapeutic uses thereof |
| DK2603600T3 (da) | 2010-08-13 | 2019-03-04 | Aileron Therapeutics Inc | Peptidomimetiske makrocyklusser |
| KR20140027284A (ko) | 2011-04-21 | 2014-03-06 | 쎄러테크놀로지스 인코포레이티드 | 성장 호르몬 방출 인자(grf) 유사체 및 이의 용도 |
| BR112014009418A2 (pt) | 2011-10-18 | 2017-04-18 | Aileron Therapeutics Inc | macrociclos peptidomiméticos |
| CN112500466B (zh) | 2012-02-15 | 2022-05-03 | 艾瑞朗医疗公司 | 拟肽大环化合物 |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| CA2961258A1 (en) | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CA2979847A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| JP1788993S (ja) * | 2024-01-12 | 2025-01-15 | 太陽光発電インバータ |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ204456A (en) * | 1982-06-16 | 1987-05-29 | Salk Inst For Biological Studi | Synthetic pancreatic growth-hormone releasing factor |
| IL70530A (en) * | 1983-01-13 | 1986-09-30 | Salk Inst For Biological Studi | Synthetic peptides having growth hormone releasing factor activity and compositions containing them |
| IL71150A (en) * | 1983-03-07 | 1987-02-27 | Sparamedica Ag | Growth hormone releasing factor analogs,their preparation and pharmaceutical compositions containing them |
| AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
| PT79094B (en) * | 1983-08-29 | 1986-08-14 | Salk Inst For Biological Studi | Grf analogs |
-
1983
- 1983-10-25 US US06/545,094 patent/US4518586A/en not_active Expired - Lifetime
-
1984
- 1984-08-29 IL IL72799A patent/IL72799A/xx not_active IP Right Cessation
- 1984-08-31 AU AU32594/84A patent/AU577057B2/en not_active Expired
- 1984-09-06 IN IN682/MAS/84A patent/IN160247B/en unknown
- 1984-09-11 NO NO843592A patent/NO166944C/no not_active IP Right Cessation
- 1984-09-11 GR GR80335A patent/GR80335B/el unknown
- 1984-09-11 DK DK433684A patent/DK165749C/da not_active IP Right Cessation
- 1984-09-11 MX MX202665A patent/MX161018A/es unknown
- 1984-09-11 PT PT79189A patent/PT79189B/pt unknown
- 1984-09-12 NZ NZ209515A patent/NZ209515A/xx unknown
- 1984-09-12 DE DE8484306234T patent/DE3462603D1/de not_active Expired
- 1984-09-12 ES ES535846A patent/ES535846A0/es active Granted
- 1984-09-12 HU HU843447A patent/HU200192B/hu unknown
- 1984-09-12 YU YU157984A patent/YU45968B/sh unknown
- 1984-09-12 IE IE2324/84A patent/IE57774B1/en not_active IP Right Cessation
- 1984-09-12 EP EP84306234A patent/EP0146210B1/en not_active Expired
- 1984-09-12 SU SU843791983A patent/SU1435157A3/ru active
- 1984-09-12 FI FI843579A patent/FI88402C/fi not_active IP Right Cessation
- 1984-09-13 JP JP59192420A patent/JPH0689035B2/ja not_active Expired - Lifetime
- 1984-09-13 CA CA000463107A patent/CA1271599A/en not_active Expired - Lifetime
- 1984-09-13 PH PH31207A patent/PH22310A/en unknown
Also Published As
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