ES8506660A1 - Un procedimiento para la preparacion de un compuesto de b-lactama - Google Patents
Un procedimiento para la preparacion de un compuesto de b-lactamaInfo
- Publication number
- ES8506660A1 ES8506660A1 ES528297A ES528297A ES8506660A1 ES 8506660 A1 ES8506660 A1 ES 8506660A1 ES 528297 A ES528297 A ES 528297A ES 528297 A ES528297 A ES 528297A ES 8506660 A1 ES8506660 A1 ES 8506660A1
- Authority
- ES
- Spain
- Prior art keywords
- lactams
- compounds containing
- containing beta
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 150000003952 β-lactams Chemical class 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 229910052740 iodine Chemical group 0.000 abstract 1
- 239000011630 iodine Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE COMPUESTO DE FORMULA (I) O UNA SAL O ESTER DE LOS MISMOS, DONDE X ES CLORO, BROMO O YODO.POR HALOGENACION DE UN COMPUESTO DE FORMULA (II), DONDE R2 ES UN GRUPO PROTECTOR DEL CARBOXI; Y, EVENTUALMENTE, SEPARAR EL GRUPO PROTECTOR DEL CARBOXI Y CONVERTIR UNA SAL EN EL ACIDO CARBOXILICO LIBRE, ESTER O UNA SAL DIFERENTE. LA REACCION TIENE LUGAR EN HEXAMETILFOSFORAMIDA, PREFERIBLEMENTE A TEMPERATURA ENTRE 30JC Y 50JC. LA HALOGENACION PUEDE REALIZARSE CON HALOGENANTES COMO UN HALURO DE TIONILO.DE APLICACION POR SU ACTIVIDAD ANTIBACTERIANA E INHIBIDORA DE BBB-LACTAMASA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8236794 | 1982-12-24 | ||
| GB838302303A GB8302303D0 (en) | 1983-01-27 | 1983-01-27 | Compounds containing beta-lactams |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8506660A1 true ES8506660A1 (es) | 1985-08-01 |
| ES528297A0 ES528297A0 (es) | 1985-08-01 |
Family
ID=26284786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES528297A Granted ES528297A0 (es) | 1982-12-24 | 1983-12-22 | Un procedimiento para la preparacion de un compuesto de b-lactama |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0112685B1 (es) |
| AU (1) | AU2279083A (es) |
| DE (1) | DE3363200D1 (es) |
| ES (1) | ES528297A0 (es) |
| GR (1) | GR79139B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4609495A (en) * | 1975-10-13 | 1986-09-02 | Beecham Group P.L.C. | Clavulanic acid ethers as antibacterial agents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1572289A (en) * | 1975-12-17 | 1980-07-30 | Glaxo Lab Ltd | Clavulanic acid derivatives |
| EP0002370B1 (en) * | 1977-12-02 | 1983-05-11 | Beecham Group Plc | A process for the preparation of ether derivatives of clavulanic acid |
-
1983
- 1983-12-14 EP EP19830307600 patent/EP0112685B1/en not_active Expired
- 1983-12-14 DE DE8383307600T patent/DE3363200D1/de not_active Expired
- 1983-12-22 ES ES528297A patent/ES528297A0/es active Granted
- 1983-12-22 GR GR73341A patent/GR79139B/el unknown
- 1983-12-22 AU AU22790/83A patent/AU2279083A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE3363200D1 (en) | 1986-05-28 |
| ES528297A0 (es) | 1985-08-01 |
| AU2279083A (en) | 1984-06-28 |
| GR79139B (es) | 1984-10-02 |
| EP0112685A1 (en) | 1984-07-04 |
| EP0112685B1 (en) | 1986-04-23 |
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