[go: up one dir, main page]

ES8506640A1 - Metodo para preparar 2-(4-terc-butil-2,6-diclorofenilimino)-imidazolidina - Google Patents

Metodo para preparar 2-(4-terc-butil-2,6-diclorofenilimino)-imidazolidina

Info

Publication number
ES8506640A1
ES8506640A1 ES528306A ES528306A ES8506640A1 ES 8506640 A1 ES8506640 A1 ES 8506640A1 ES 528306 A ES528306 A ES 528306A ES 528306 A ES528306 A ES 528306A ES 8506640 A1 ES8506640 A1 ES 8506640A1
Authority
ES
Spain
Prior art keywords
dichlorophenylimino
imidazolidine
tert
butyl
clonidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528306A
Other languages
English (en)
Other versions
ES528306A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of ES8506640A1 publication Critical patent/ES8506640A1/es
Publication of ES528306A0 publication Critical patent/ES528306A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/16—Isothiocyanates
    • C07C331/28—Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO DE PREPARACION DE 2-(4-TERC-BUTIL-2,6-DICLOROFENILIMINO)-IMIDAZOLIDINA.POR REACCION DE 1-(4-TERC-BUTIL-2,6-DICLOROFENIL)-2-(2-AMINOETIL)-TIOUREA, BAJO CONDICIONES DE CIERRE DE ANILLO QUE INDUCEN LA CONDENSACION DEL GRUPO TIOXO CON EL GRUPO AMINO PRIMARIO; PUEDEN CONSEGUIRSE ESTAS CONDICIONES POR REACCION CON OXIDO MERCURICO, CALENTANDO EN ALCOHOL A REFLUJO. LAS SALES FARMACOLOGICAMENTE ACEPTABLES SE PREPARAN CON ACIDOS CLORHIDRICO, BROMHIDRICO, FOSOFORICO, METANOSULFONICO, SULFAMICO, ETANODISULFONICO O SULFURICO.DE APLICACION POR SU ACTIVIDAD ANTIHIPERTENSORA.
ES528306A 1982-12-23 1983-12-22 Metodo para preparar 2-(4-terc-butil-2,6-diclorofenilimino)-imidazolidina Granted ES528306A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/452,676 US4444782A (en) 1982-12-23 1982-12-23 2(4-tert.-Butyl-2,6-dichlorophenyl-imino)imidazolidine and use as an anti-hypertension agent

Publications (2)

Publication Number Publication Date
ES8506640A1 true ES8506640A1 (es) 1985-08-01
ES528306A0 ES528306A0 (es) 1985-08-01

Family

ID=23797446

Family Applications (1)

Application Number Title Priority Date Filing Date
ES528306A Granted ES528306A0 (es) 1982-12-23 1983-12-22 Metodo para preparar 2-(4-terc-butil-2,6-diclorofenilimino)-imidazolidina

Country Status (10)

Country Link
US (1) US4444782A (es)
EP (1) EP0116768A1 (es)
JP (1) JPS59118770A (es)
AU (1) AU569583B2 (es)
CA (1) CA1199926A (es)
DK (1) DK565083A (es)
ES (1) ES528306A0 (es)
GR (1) GR79478B (es)
PT (1) PT77861B (es)
ZA (1) ZA838913B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801617A (en) * 1987-04-06 1989-01-31 Leclerc Gerard Iminoimidazolidines useful in lowering intraocular pressure
US4897412A (en) * 1987-04-06 1990-01-30 Laboratories Alcon S.A. Imidazolines useful in lowering intraocular pressure
WO1995021818A1 (en) * 1994-02-08 1995-08-17 Alcon Laboratories, Inc. Novel process for preparation of clonidine derivatives
US20020169193A1 (en) * 2001-02-10 2002-11-14 Pascale Pouzet Alkylphenyliminoimidazolidine derivatives for treating urinary incontinence

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236857A (en) * 1961-10-09 1966-02-22 Boehringer Sohn Ingelheim 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products
NL123037C (es) * 1963-10-04
AT285599B (de) * 1968-06-21 1970-11-10 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen trisubstituierten 2-Arylaminoimidazolinen und ihren Salzen
US4287201A (en) * 1980-03-03 1981-09-01 Merck & Co., Inc. Anovulatory method and chicken feed compositions
EP0043659B1 (en) * 1980-07-09 1985-02-06 Beecham Group Plc Clonidine derivatives useful in the treatment of diarrhoea

Also Published As

Publication number Publication date
DK565083A (da) 1984-06-24
AU569583B2 (en) 1988-02-11
JPS59118770A (ja) 1984-07-09
CA1199926A (en) 1986-01-28
AU2197883A (en) 1984-06-28
ES528306A0 (es) 1985-08-01
EP0116768A1 (en) 1984-08-29
ZA838913B (en) 1985-02-27
US4444782A (en) 1984-04-24
PT77861A (en) 1984-01-01
DK565083D0 (da) 1983-12-08
PT77861B (en) 1986-04-09
GR79478B (es) 1984-10-30

Similar Documents

Publication Publication Date Title
MY102191A (en) Herbicidal aryl triazolinones
SG138493G (en) Heterocyclic compounds.
IT1139681B (it) Procedimento per la fabbricazione di un accumulatore al piombo,nonche' accumulatore al piombo fabbricato secondo questo procedimento
ES2032229T3 (es) Inhibidores de proteasas benzamidicos.
FR2515179B1 (es)
FI851670L (fi) Matningsbalk foer en bergborrmaskin.
DE3275184D1 (de) 2-(trisubstituted phenylimino)-imidazolines
IT1160125B (it) Reattore per l'assimilazione anaerobica di fanghi organici
ES8506640A1 (es) Metodo para preparar 2-(4-terc-butil-2,6-diclorofenilimino)-imidazolidina
ES8602752A1 (es) Procedimiento para preparar nuevos compuestos de imidazolidinona e imidazolidintiona con actividad herbicida
FR2445318A1 (fr) Procede de preparation de 1-(3-mercapto-propanoyl)-l-prolines
EP0208964A3 (en) 1,5-benzothiazepine compounds
SE8201019L (sv) Amino-2,1,3-bensotiadiazol- och -bensooxadiazolderivat, deras framstellningoch lekemedel innehallande desamma
DE3579280D1 (de) Hydratationsverfahren von nitrilverbindungen.
RO83439A (ro) Procedeu pentru prepararea n-cian-n'-metil-n"-(2-((5metil-1h-imidazol-4-il)-metil)-tio)-etil-guanidinei
ES2009921A6 (es) Procedimiento para la obtencion de derivados imidazolicos.
ATE17228T1 (de) Verfahren zur oxydation von vinylbenzenverbindungen zu beta-phenylaldehyden.
EP0269739A4 (en) IMIDAZOLES 1,5-BISUBSTITUES.
IE812897L (en) Buspirone process
ES8505964A1 (es) Procedimiento de obtencion de un compuesto derivado de la n-fenil-n'-butil-urea
ATE19241T1 (de) 4-aminomethyl-5-acyl-1,3-dihydro-imidazol-2-one
MY103207A (en) Cyanoguanidine derivative and process for preparation thereof
FR2590577B1 (fr) Agent inhibiteur d'homopolymerisation pour reaction radicalaire de greffage, procede de greffage utilisant ledit agent
UA12838A (uk) Спосіб боротьби з таргаhами
MY101988A (en) 4-aminoalkyl-2<3h>-indolones