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ES8503670A1 - Process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone. - Google Patents

Process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone.

Info

Publication number
ES8503670A1
ES8503670A1 ES523540A ES523540A ES8503670A1 ES 8503670 A1 ES8503670 A1 ES 8503670A1 ES 523540 A ES523540 A ES 523540A ES 523540 A ES523540 A ES 523540A ES 8503670 A1 ES8503670 A1 ES 8503670A1
Authority
ES
Spain
Prior art keywords
pyridazinone
hydroxyphenyl
preparing
mixture
hydroxyacetophenone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523540A
Other languages
Spanish (es)
Other versions
ES523540A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES523540A0 publication Critical patent/ES523540A0/en
Publication of ES8503670A1 publication Critical patent/ES8503670A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone which comprises reacting 2-hydroxyacetophenone with glyoxylic acid under alkaline conditions, adjusting the pH of the reaction mixture to give a mixture within a pH range of about pH 4.0-9.5 and which contains a weak base, and subsequently reacting with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinone is a useful intermediate in the preparation of anti-hypertensive agents.
ES523540A 1982-06-24 1983-06-23 Process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone. Expired ES8503670A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8218373 1982-06-24

Publications (2)

Publication Number Publication Date
ES523540A0 ES523540A0 (en) 1985-03-01
ES8503670A1 true ES8503670A1 (en) 1985-03-01

Family

ID=10531259

Family Applications (1)

Application Number Title Priority Date Filing Date
ES523540A Expired ES8503670A1 (en) 1982-06-24 1983-06-23 Process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone.

Country Status (9)

Country Link
US (1) US4528371A (en)
EP (1) EP0101156A3 (en)
JP (1) JPS597133A (en)
KR (1) KR840005106A (en)
AU (1) AU1598983A (en)
DK (1) DK281483A (en)
ES (1) ES8503670A1 (en)
GR (1) GR79301B (en)
PT (1) PT76900B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071688A (en) * 1998-07-29 2000-06-06 Eastman Kodak Company Providing additives to a coating composition by vaporization

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1383906A (en) * 1971-02-22 1974-02-12 Bdh Pharmaceuticals Ltd Pyridazinones
IE42214B1 (en) * 1974-06-18 1980-07-02 Smith Kline French Lab Hydrazinopyredazines
US4111936A (en) * 1974-06-18 1978-09-05 Smith Kline & French Laboratories Limited Pyridazinethiones
DE2435244A1 (en) * 1974-07-22 1976-02-05 Lentia Gmbh PROCESS FOR THE PREPARATION OF 3-PHENYLPYRIDAZONES
AT343125B (en) * 1976-03-24 1978-05-10 Chemie Linz Ag METHOD FOR PREPARING 3-PHENYLPYRIDAZONE- (6)
US4152517A (en) * 1977-10-19 1979-05-01 Smithkline Corporation Synthesis of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones from trihalocarbinols
DE2819798A1 (en) * 1978-05-05 1979-11-08 Lentia Gmbh PROCESS FOR PRODUCING 3-PHENYL-PYRIDAZONE- (6)

Also Published As

Publication number Publication date
GR79301B (en) 1984-10-22
DK281483D0 (en) 1983-06-17
DK281483A (en) 1983-12-25
JPS597133A (en) 1984-01-14
EP0101156A3 (en) 1984-08-22
KR840005106A (en) 1984-11-03
ES523540A0 (en) 1985-03-01
EP0101156A2 (en) 1984-02-22
PT76900A (en) 1983-07-01
US4528371A (en) 1985-07-09
PT76900B (en) 1986-01-24
AU1598983A (en) 1984-01-05

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