[go: up one dir, main page]

ES8503006A1 - Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico - Google Patents

Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico

Info

Publication number
ES8503006A1
ES8503006A1 ES525614A ES525614A ES8503006A1 ES 8503006 A1 ES8503006 A1 ES 8503006A1 ES 525614 A ES525614 A ES 525614A ES 525614 A ES525614 A ES 525614A ES 8503006 A1 ES8503006 A1 ES 8503006A1
Authority
ES
Spain
Prior art keywords
methylphenoxicarbonyl
procedure
preparation
acid
carboxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525614A
Other languages
English (en)
Other versions
ES525614A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES525614A0 publication Critical patent/ES525614A0/es
Publication of ES8503006A1 publication Critical patent/ES8503006A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ACIDO 6,BAB-METOXI-6,BBB-2-(2-METILFENOXICARBONIL)-2-(TIEN-3-IL)ACETAMIDOPENICILANICO.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON METANOL EN PRESENCIA DE UN ION METALICO, COMO UNA SAL DE TELURO, PLOMO, PLATA, COBRE, BISMUTO, MERCURIO, PLOMO, CADMIO O TALIO, PARA OBTENER COMPUESTOS DE FORMULA (I). POSTERIORMENTE SE LLEVA A CABO: SEPARAR CUALQUIER SUSTITUYENTE DEL GRUPO AMIDO; SEPARAR EL GRUPO BLOQUEANTE DE CARBOXI RX; Y CONVERTIR EL PRODUCTO EN UNA SAL O EN UN ESTER HIDROLIZANTE IN VIVO DEL MISMO. RX SIGNIFICA UN GRUPO BLOQUEANTE DE CARBOXI Y R4 ES ALQUILO C 1 A 6, BENCILO O UN GRUPO ARILO. LA REACCION SE EFECTUA ENTRE C50JC Y B25JC DE TEMPERATURA.TIENE APLICACION FARMACEUTICA POR SU ACTIVIDAD CONTRA BACTERIAS GRAM-NEGATIVAS.
ES525614A 1982-01-22 1983-09-14 Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico Expired ES8503006A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8201751 1982-01-22

Publications (2)

Publication Number Publication Date
ES525614A0 ES525614A0 (es) 1985-02-01
ES8503006A1 true ES8503006A1 (es) 1985-02-01

Family

ID=10527789

Family Applications (4)

Application Number Title Priority Date Filing Date
ES519190A Granted ES519190A0 (es) 1982-01-22 1983-01-21 Un procedimiento para la preparacion de acido 6,-metoxi-6, -2-2-metilfenoxicarbonil-2-(tien-3-il) acetamido penicilanico.
ES525613A Expired ES8503005A1 (es) 1982-01-22 1983-09-14 Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico
ES525614A Expired ES8503006A1 (es) 1982-01-22 1983-09-14 Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico
ES525612A Granted ES525612A0 (es) 1982-01-22 1983-09-14 Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES519190A Granted ES519190A0 (es) 1982-01-22 1983-01-21 Un procedimiento para la preparacion de acido 6,-metoxi-6, -2-2-metilfenoxicarbonil-2-(tien-3-il) acetamido penicilanico.
ES525613A Expired ES8503005A1 (es) 1982-01-22 1983-09-14 Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES525612A Granted ES525612A0 (es) 1982-01-22 1983-09-14 Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico

Country Status (18)

Country Link
US (1) US4455314A (es)
EP (1) EP0084948B1 (es)
JP (1) JPS58128389A (es)
KR (1) KR840003258A (es)
AT (1) ATE30592T1 (es)
AU (1) AU560185B2 (es)
CA (1) CA1217479A (es)
DE (1) DE3374316D1 (es)
DK (1) DK22983A (es)
ES (4) ES519190A0 (es)
FI (1) FI830192L (es)
GR (1) GR77867B (es)
IL (1) IL67672A0 (es)
NO (1) NO830183L (es)
NZ (1) NZ203065A (es)
PL (4) PL245812A1 (es)
PT (1) PT76128B (es)
ZA (1) ZA83377B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201922977A2 (tr) * 2019-12-31 2021-07-26 T C Erciyes Ueniversitesi Penisilin türevleri ve bunların sentezlenmesi için yöntem

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853849A (en) * 1969-05-29 1974-12-10 Beecham Group Ltd Alpha(aryloxycarbonyl)-and alpha(alkoxy-carbonyl)-aralkyl penicillins
HU168914B (es) * 1974-07-30 1976-08-28
GB1538051A (en) * 1975-01-17 1979-01-10 Beecham Group Ltd 6-methoxy-6-(alpha-carboxyacetamido)-penicillins
US4185014A (en) * 1976-06-26 1980-01-22 Beecham Group Limited Kentenimine intermediates for 6α-methoxy-α-carboxy penicillins
GB1577931A (en) * 1977-02-11 1980-10-29 Beecham Group Ltd 6-methoxy -6-(2-carboxy-2-(4-hydroxyphenyl) acetamido penicillins
ZA802445B (en) * 1979-05-15 1981-04-29 Beecham Group Ltd Process for the preparation of penicillin derivatives
NZ194912A (en) * 1979-10-02 1983-05-31 Beecham Group Ltd 6 -(2-(2'-methylphenoxycarbonyl)-2-thien-3'-ylacetamido)-penicillanic acid and pharmaceutical compositions

Also Published As

Publication number Publication date
FI830192A7 (fi) 1983-07-23
ATE30592T1 (de) 1987-11-15
NZ203065A (en) 1986-10-08
KR840003258A (ko) 1984-08-20
IL67672A0 (en) 1983-05-15
ES525614A0 (es) 1985-02-01
ZA83377B (en) 1983-10-26
NO830183L (no) 1983-07-25
PL240238A1 (en) 1984-06-18
DK22983D0 (da) 1983-01-20
PL245812A1 (en) 1984-09-24
PT76128B (en) 1987-02-05
EP0084948A1 (en) 1983-08-03
AU560185B2 (en) 1987-04-02
GR77867B (es) 1984-09-25
PT76128A (en) 1983-02-01
FI830192L (fi) 1983-07-23
PL245814A1 (en) 1984-09-24
JPS58128389A (ja) 1983-07-30
ES8503004A1 (es) 1985-02-01
DK22983A (da) 1983-07-23
AU1064083A (en) 1983-07-28
CA1217479A (en) 1987-02-03
ES525613A0 (es) 1985-02-01
DE3374316D1 (en) 1987-12-10
ES8503005A1 (es) 1985-02-01
ES8403135A1 (es) 1984-03-01
EP0084948B1 (en) 1987-11-04
US4455314A (en) 1984-06-19
FI830192A0 (fi) 1983-01-20
PL245813A1 (en) 1984-09-24
ES519190A0 (es) 1984-03-01
ES525612A0 (es) 1985-02-01

Similar Documents

Publication Publication Date Title
CA1205805A (es)
ES8504168A1 (es) Un procedimiento para la preparacion de benzotienil benzofuranil o naftil-derivados.
ES8402558A1 (es) "un procedimiento para preparar una n-(4-(3-aminopropil)-aminobutil)-2-(acido-guanidino-graso-amido)-etanamida sustituida en posicion 2".
ES480721A1 (es) Un procedimiento para aislar pseudomonato de litio.
ES8503006A1 (es) Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico
ES8300756A1 (es) Un procedimiento para la preparacion de una isoxazolilimida-zolidinona
FR2430199A1 (fr) Procede pour la protection des matieres keratiniques contre l'attaque des insectes mangeurs de keratine
ES8201169A1 (es) Un procedimiento para la preparacion de derivados de quina- zolina
ES8703883A1 (es) Un procedimiento para la preparacion de una cefalosporina
ES466493A1 (es) Procedimiento de fabricacion de acidos a-aril-a -oxo-isovalericos.
ES8207523A1 (es) Metodo para la preparacion de n-(2-(((5-dialquilamino)-me- til-2-metil-2-furanil)-metil)-etil)-n'alquil-2-nitro-1,1- etendiamina
JPS5740496A (en) Low toxic derivative of istamycin antibiotic
IT1156483B (it) Prodotti di trattamento di polimeri poliidrossilici e poliamminici e procedimento che utilizza questi prodotti
ES8500898A1 (es) Procedimiento para preparar esteres de acidos benzosulfonicos substituidos.
ES2005165A6 (es) Procedimiento de preparacion del complejo de cincl de 5-cloro-7-yodo-8-hidroxi-quinolina
JPS5334716A (en) Preparation of amide amine amphoteric surface active agent
JPS53119820A (en) Preparation of alkali aminodiacetate
ES344031A1 (es) Un procedimiento para producir una composicion de dl-metio-nina.
ES2016474A6 (es) Procedimiento para la preparacion de un nuevo derivado naftilpropionico.
ES8403915A1 (es) Un procedimiento para la preparacion de un derivado de b -lactama.
JPS5651493A (en) Diphosphoglycerol and its preparation
JPS57144291A (en) Preparation of imidazoledicarboxylic acid derivative
ES8100243A1 (es) Un procedimiento para la preparacion de derivados de acido tro-clorocitrico
JPS5540617A (en) Mitomycin derivative
JPS5653678A (en) Preparation of 1,10-phenanthroilnes