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ES8502087A1 - Un procedimiento para preparar un compuesto que contiene un vehiculo redox de dihidropiridina-sal de piridinio. - Google Patents

Un procedimiento para preparar un compuesto que contiene un vehiculo redox de dihidropiridina-sal de piridinio.

Info

Publication number
ES8502087A1
ES8502087A1 ES522489A ES522489A ES8502087A1 ES 8502087 A1 ES8502087 A1 ES 8502087A1 ES 522489 A ES522489 A ES 522489A ES 522489 A ES522489 A ES 522489A ES 8502087 A1 ES8502087 A1 ES 8502087A1
Authority
ES
Spain
Prior art keywords
dihydropyridine
brain
centrally acting
acting drug
drug species
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522489A
Other languages
English (en)
Other versions
ES522489A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
Original Assignee
University of Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/379,316 external-priority patent/US4479932A/en
Priority claimed from US06/475,493 external-priority patent/US4622218A/en
Application filed by University of Florida filed Critical University of Florida
Publication of ES8502087A1 publication Critical patent/ES8502087A1/es
Publication of ES522489A0 publication Critical patent/ES522489A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/559—Redox delivery systems, e.g. dihydropyridine pyridinium salt redox systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN COMPUESTO QUE CONTIENE UN VEHICULOS REDOX DE DIHIDROPIRIDINA/SAL DE PIRIDINO.CONSISTE EN REDUCIR UN COMPUESTO DE FORMULA (II) PARA PRODUCIR UN COMPUESTO DE FORMULA (I) DONDE D ES UN FARMACO QUE CONTIENE UN SOLO GRUPO FUNCIONAL NH2 O OH, PUDIENDO SER AL MISMO TIEMPO UNA DOPAMINA Y PUDIENDO SER TAMBIEN GABA, GLICINA, ACIDO GLUTAMICO, ACIDO ASPARTICO, BIOOXIDABLE Y CAPAZ DE ATRAVESAR LA BARRERA SANGRE-CEREBRO DE UN VEHICULO REDOX DE DIHIDROPIRIDINASAL DE PIRADINO; Y QCB ES LA FORMA HIDROFILA, DE SAL IONICA DE PIRIDINO, DE UN VEHICULO REDOX DE DIHIDROPIRIDINASAL DE PIRIDINO. COMO AGENTE REDUCTOR SE UTILIZA UN DITIONITO DE METAL ALCALINO TAL COMO DITIONITO SODICO.
ES522489A 1982-05-18 1983-05-17 Un procedimiento para preparar un compuesto que contiene un vehiculo redox de dihidropiridina-sal de piridinio. Granted ES522489A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/379,316 US4479932A (en) 1982-05-18 1982-05-18 Brain-specific drug delivery
US46154383A 1983-01-27 1983-01-27
US06/475,493 US4622218A (en) 1982-05-18 1983-03-15 Testicular-specific drug delivery

Publications (2)

Publication Number Publication Date
ES8502087A1 true ES8502087A1 (es) 1984-12-16
ES522489A0 ES522489A0 (es) 1984-12-16

Family

ID=27409446

Family Applications (1)

Application Number Title Priority Date Filing Date
ES522489A Granted ES522489A0 (es) 1982-05-18 1983-05-17 Un procedimiento para preparar un compuesto que contiene un vehiculo redox de dihidropiridina-sal de piridinio.

Country Status (9)

Country Link
EP (6) EP0110955B1 (es)
AT (1) ATE126695T1 (es)
AU (1) AU567433B2 (es)
CA (2) CA1253856A (es)
DE (1) DE3382795T2 (es)
ES (1) ES522489A0 (es)
IE (1) IE69557B1 (es)
IT (1) IT1171851B (es)
WO (1) WO1983003968A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4771059A (en) * 1984-02-29 1988-09-13 University Of Florida Brain-specific analogues of centrally acting amines
US5082853A (en) * 1984-02-29 1992-01-21 Bodor Nicholas S Brain-specific analogues of centrally acting amines
US4933438A (en) * 1984-02-29 1990-06-12 University Of Florida Brain-specific analogues of centrally acting amines
WO1985003937A1 (en) * 1984-02-29 1985-09-12 University Of Florida Brain-specific analogues of centrally acting amines
EP0191788A1 (en) * 1984-07-19 1986-08-27 University Of Florida Novel radiopharmaceuticals and chelating agents useful in their preparation
US4963688A (en) * 1984-07-19 1990-10-16 University Of Florida Compounds for site-enhanced delivery of radionuclides and uses thereof
FI861118A0 (fi) * 1984-07-19 1986-03-18 Univ Florida Foereningar befraemjande radionukleiders maolspecificitet och anvaendning av dessa.
US4764598A (en) * 1985-08-22 1988-08-16 The United States Of America As Represented By The Department Of Energy Precursors to radiopharmaceutical agents for tissue imaging
US4863911A (en) * 1986-08-04 1989-09-05 University Of Florida Method for treating male sexual dysfunction
US4888427A (en) * 1987-04-07 1989-12-19 University Of Florida Amino acids containing dihydropyridine ring systems for site-specific delivery of peptides to the brain
US5079366A (en) * 1987-04-07 1992-01-07 University Of Florida Quarternary pyridinium salts
US5017566A (en) * 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
US5002935A (en) * 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
DK0386644T3 (da) * 1989-03-10 1997-10-13 Hoffmann La Roche Reagenser til bestemmelse af lægemidler
IL106998A0 (en) * 1992-09-17 1993-12-28 Univ Florida Brain-enhanced delivery of neuroactive peptides by sequential metabolism
KR101301577B1 (ko) * 2010-08-20 2013-08-29 주식회사 바이오에프디엔씨 니코티노일 펩타이드 유도체 및 그를 포함하는 화장료 조성물
DK2794597T3 (en) 2011-12-21 2018-01-15 Ono Pharmaceutical Co PYRIDINON AND PYRIMIDINON DERIVATIVES AS FACTOR XIA INHIBITORS
CN109153639B (zh) * 2016-03-14 2022-07-29 斯法尔制药私人有限公司 葫芦巴碱类化合物
WO2018054723A1 (en) 2016-09-26 2018-03-29 Basf Se Pyridine compounds for controlling phytopathogenic harmful fungi
WO2018054711A1 (en) 2016-09-26 2018-03-29 Basf Se Pyridine compounds for controlling phytopathogenic harmful fungi
WO2018054721A1 (en) 2016-09-26 2018-03-29 Basf Se Pyridine compounds for controlling phytopathogenic harmful fungi
WO2018065182A1 (en) 2016-10-04 2018-04-12 Basf Se Reduced quinoline compounds as antifuni agents
WO2018073110A1 (en) 2016-10-20 2018-04-26 Basf Se Quinoline compounds as fungicides
BR112019014061A2 (pt) 2017-01-23 2020-02-04 Basf Se compostos de fórmula i, intermediários b, intermediários c, intermediários ii e intermediários d, composição, uso, método para combater fungos fitopatogênicos, semente e processo para a síntese dos compostos de fórmula i
CN110475772A (zh) 2017-04-06 2019-11-19 巴斯夫欧洲公司 吡啶化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929813A (en) 1973-12-26 1975-12-30 Interx Research Corp Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and process for preparing same
US3962447A (en) 1973-12-26 1976-06-08 Interx Research Corporation Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and method of using same
US4069322A (en) * 1976-10-12 1978-01-17 Interx Research Corporation Pro-drugs for the improved delivery of certain selected anti-inflammatory steroids
US4206220A (en) * 1978-07-13 1980-06-03 Interx Research Corporation Prodrugs for the improved delivery of non-steroidal anti-inflammatory agents

Also Published As

Publication number Publication date
EP0256577A3 (en) 1988-07-06
EP0262696A3 (en) 1988-07-20
CA1253856A (en) 1989-05-09
IT8348327A0 (it) 1983-05-18
IT1171851B (it) 1987-06-10
EP0110955A1 (en) 1984-06-20
IE931149L (en) 1983-11-18
EP0262696A2 (en) 1988-04-06
AU567433B2 (en) 1987-11-19
DE3382795D1 (de) 1995-09-28
EP0256577A2 (en) 1988-02-24
CA1327566C (en) 1994-03-08
EP0221588A2 (en) 1987-05-13
ATE126695T1 (de) 1995-09-15
EP0221588A3 (en) 1988-09-21
WO1983003968A1 (en) 1983-11-24
EP0110955B1 (en) 1995-08-23
EP0222425A3 (en) 1988-09-21
EP0224283A3 (en) 1988-09-21
EP0222425A2 (en) 1987-05-20
EP0224283A2 (en) 1987-06-03
IE69557B1 (en) 1996-10-02
DE3382795T2 (de) 1996-02-15
ES522489A0 (es) 1984-12-16
IE831149L (en) 1983-11-18
AU1703483A (en) 1983-12-02

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