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ES8501363A1 - PROCEDURES FOR OBTAINING AMIDOAMINOACIDES AND THE LIKE. - Google Patents

PROCEDURES FOR OBTAINING AMIDOAMINOACIDES AND THE LIKE.

Info

Publication number
ES8501363A1
ES8501363A1 ES521031A ES521031A ES8501363A1 ES 8501363 A1 ES8501363 A1 ES 8501363A1 ES 521031 A ES521031 A ES 521031A ES 521031 A ES521031 A ES 521031A ES 8501363 A1 ES8501363 A1 ES 8501363A1
Authority
ES
Spain
Prior art keywords
obtaining
amidoaminoacides
procedures
compounds
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521031A
Other languages
Spanish (es)
Other versions
ES521031A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
USV Pharmaceutical Corp
Original Assignee
USV Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by USV Pharmaceutical Corp filed Critical USV Pharmaceutical Corp
Publication of ES521031A0 publication Critical patent/ES521031A0/en
Publication of ES8501363A1 publication Critical patent/ES8501363A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE AMIDOAMINOACIDOS Y SIMILARES, EN PARTICULAR, PARA PREPARAR COMPUESTOS DE FORMULA GENERAL (I), Y SUS SALES DE ACIDOS O BASES, FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), CON UN ALFACETOACIDO O ESTER DE FORMULA (III), Y EN REDUCIR LA IMINA RESULTANTE EN PRESENCIA DE UN CATALIZADOR METALICO, A UNA TEMPERATURA DE HASTA 180 GRADOS.DE APLICACION EN LA PREPARACION DE COMPUESTOS DE ACTIVIDAD AHTIHIPERTENSORA E INHIBIDORA DE LA ENZIMA DE CONVERSION DE LA ANGIOTENSINA.PROCEDURE FOR OBTAINING AMIDOAMINO ACIDS AND SIMILARS, IN PARTICULAR, TO PREPARE COMPOUNDS OF GENERAL FORMULA (I), AND THEIR ACID SALTS OR BASES, PHARMACEUTICALLY ACCEPTABLE. OF FORMULA (III), AND IN REDUCING THE RESULTING IMINE IN THE PRESENCE OF A METALLIC CATALYST, AT A TEMPERATURE OF UP TO 180 DEGREES OF APPLICATION IN THE PREPARATION OF COMPOUNDS OF AHTI-HYPERTENSION AND INHIBITOR ACTIVITY OF THE ANGIOTENSIN CONVERSION ENZYME.

ES521031A 1981-03-19 1983-03-16 PROCEDURES FOR OBTAINING AMIDOAMINOACIDES AND THE LIKE. Expired ES8501363A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24540781A 1981-03-19 1981-03-19

Publications (2)

Publication Number Publication Date
ES521031A0 ES521031A0 (en) 1984-12-01
ES8501363A1 true ES8501363A1 (en) 1984-12-01

Family

ID=22926526

Family Applications (3)

Application Number Title Priority Date Filing Date
ES510498A Granted ES510498A0 (en) 1981-03-19 1982-03-17 "PROCEDURE TO PREPARE AMIDOAMINOACIDOS AND SIMILAR".
ES521031A Expired ES8501363A1 (en) 1981-03-19 1983-03-16 PROCEDURES FOR OBTAINING AMIDOAMINOACIDES AND THE LIKE.
ES521030A Granted ES521030A0 (en) 1981-03-19 1983-03-16 METHOD OF PREPARING AMINO AMINO ACIDS AND ANALOGS.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES510498A Granted ES510498A0 (en) 1981-03-19 1982-03-17 "PROCEDURE TO PREPARE AMIDOAMINOACIDOS AND SIMILAR".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES521030A Granted ES521030A0 (en) 1981-03-19 1983-03-16 METHOD OF PREPARING AMINO AMINO ACIDS AND ANALOGS.

Country Status (21)

Country Link
JP (1) JPS57165355A (en)
KR (1) KR890001146B1 (en)
AU (1) AU558451B2 (en)
BE (1) BE892552A (en)
CH (1) CH658455A5 (en)
DE (1) DE3209708A1 (en)
DK (1) DK120982A (en)
ES (3) ES510498A0 (en)
FI (1) FI820974L (en)
FR (1) FR2502149A1 (en)
GB (1) GB2095252B (en)
IE (1) IE53076B1 (en)
IL (1) IL65247A (en)
IN (1) IN156096B (en)
IT (1) IT1150697B (en)
NL (1) NL8201066A (en)
NO (1) NO820903L (en)
NZ (1) NZ200047A (en)
PH (1) PH18657A (en)
SE (1) SE8201654L (en)
ZA (1) ZA821833B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3242599A1 (en) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach NEW BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4555502A (en) * 1982-09-30 1985-11-26 Merck & Co., Inc. Aminoacyl-containing dipeptide derivatives useful as antihypertensives
US4410807A (en) * 1982-03-26 1983-10-18 Kay Industries, Inc. Regulating device for polyphase electrical circuits
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
DE3302125A1 (en) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
FI841052A7 (en) * 1983-03-16 1984-09-17 Usv Pharma Corp FOERENINGAR FOER BEHANDLING AV BLODTRYCKSSJUKDOMAR.
DE3333454A1 (en) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS
DE3622297A1 (en) * 1986-07-03 1988-01-07 Basf Ag DISAZOTHIOPHENE DYES
US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
ES2122941B1 (en) * 1997-05-29 1999-07-01 Esteve Quimica Sa PROCEDURE FOR OBTAINING QUINAPRIL CHLORHYDRATE AND SOLVATES USEFUL FOR THE ISOLATION AND PURIFICATION OF QUINAPRIL CHLORHYDRATE.
PT1333026E (en) 2002-01-30 2007-09-17 Servier Lab Process for the preparation of high purity perindopril and intermediates useful in the synthesis
WO2004054980A1 (en) 2002-12-16 2004-07-01 Lupin Limited Crystalline form of quinapril hydrochloride and process for preparing the same
AU2003224420B2 (en) * 2003-02-28 2009-08-06 Les Laboratoires Servier Process for preparation of perindopril and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (en) * 1980-10-02 1982-10-08 Science Union & Cie NOVEL SUBSTITUTED IMINO DIACIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR
EP0046953B1 (en) * 1980-08-30 1989-12-06 Hoechst Aktiengesellschaft Amino acid derivatives, processes for their preparation, compositions containing them and their use
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application

Also Published As

Publication number Publication date
FI820974A7 (en) 1982-09-20
IL65247A (en) 1987-07-31
ES8404317A1 (en) 1984-05-16
ES8307718A1 (en) 1983-08-01
AU8158482A (en) 1982-09-23
FR2502149A1 (en) 1982-09-24
IE53076B1 (en) 1988-06-08
SE8201654L (en) 1982-09-20
IE820635L (en) 1982-09-19
FR2502149B1 (en) 1985-01-18
IT8220259A0 (en) 1982-03-18
ZA821833B (en) 1983-01-26
ES510498A0 (en) 1983-08-01
ES521031A0 (en) 1984-12-01
DE3209708A1 (en) 1982-10-21
DK120982A (en) 1982-09-20
GB2095252A (en) 1982-09-29
NZ200047A (en) 1985-07-12
NO820903L (en) 1982-09-20
KR830009065A (en) 1983-12-17
AU558451B2 (en) 1987-01-29
KR890001146B1 (en) 1989-04-25
GB2095252B (en) 1985-04-17
NL8201066A (en) 1982-10-18
IL65247A0 (en) 1982-05-31
ES521030A0 (en) 1984-05-16
JPS57165355A (en) 1982-10-12
PH18657A (en) 1985-08-29
IN156096B (en) 1985-05-11
BE892552A (en) 1982-09-20
CH658455A5 (en) 1986-11-14
FI820974L (en) 1982-09-20
IT1150697B (en) 1986-12-17

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