[go: up one dir, main page]

ES8500265A1 - Un procedimiento de preparacion de derivados de bencimidazol (divisional de la patente de invencion num. 514.947, presentada el 12 de agosto 1982) - Google Patents

Un procedimiento de preparacion de derivados de bencimidazol (divisional de la patente de invencion num. 514.947, presentada el 12 de agosto 1982)

Info

Publication number
ES8500265A1
ES8500265A1 ES523344A ES523344A ES8500265A1 ES 8500265 A1 ES8500265 A1 ES 8500265A1 ES 523344 A ES523344 A ES 523344A ES 523344 A ES523344 A ES 523344A ES 8500265 A1 ES8500265 A1 ES 8500265A1
Authority
ES
Spain
Prior art keywords
carbon atoms
group
oc2h5
och3
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523344A
Other languages
English (en)
Other versions
ES523344A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hassle AB
Original Assignee
Hassle AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hassle AB filed Critical Hassle AB
Publication of ES523344A0 publication Critical patent/ES523344A0/es
Publication of ES8500265A1 publication Critical patent/ES8500265A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE BENCIMIDAZOL, Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES HIDROGENO; Y R1-R5 PUEDEN SER VARIOS RADICALES.CONSISTE EN LA REACCION DE HIDROLISIS DEL COMPUESTO DE FORMULA (II), EN LA QUE Z9 ES ALCANOILO O CARBOALCOXI Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA HIDROLISIS SE EFECTUA SIGUIENDO METODOS CONVENCIONALES.ESTOS COMPUESTOS TIENEN APLICACIONES PARA EL TRATAMIENTO DE LA ULCERA PEPTICA.
ES523344A 1981-08-13 1983-06-16 Un procedimiento de preparacion de derivados de bencimidazol (divisional de la patente de invencion num. 514.947, presentada el 12 de agosto 1982) Expired ES8500265A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8104811 1981-08-13

Publications (2)

Publication Number Publication Date
ES523344A0 ES523344A0 (es) 1984-10-01
ES8500265A1 true ES8500265A1 (es) 1984-10-01

Family

ID=20344360

Family Applications (3)

Application Number Title Priority Date Filing Date
ES514947A Granted ES514947A0 (es) 1981-08-13 1982-08-12 "un procedimiento de preparacion de derivados de bencimidazol".
ES523344A Expired ES8500265A1 (es) 1981-08-13 1983-06-16 Un procedimiento de preparacion de derivados de bencimidazol (divisional de la patente de invencion num. 514.947, presentada el 12 de agosto 1982)
ES532044A Expired ES8502109A1 (es) 1981-08-13 1984-04-30 Un procedimiento de preparacion de derivados de bencimidazol.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES514947A Granted ES514947A0 (es) 1981-08-13 1982-08-12 "un procedimiento de preparacion de derivados de bencimidazol".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES532044A Expired ES8502109A1 (es) 1981-08-13 1984-04-30 Un procedimiento de preparacion de derivados de bencimidazol.

Country Status (27)

Country Link
US (1) US4746667A (es)
EP (1) EP0074341B1 (es)
JP (1) JPS5839622A (es)
KR (1) KR880001714B1 (es)
AT (1) ATE18765T1 (es)
AU (1) AU556736B2 (es)
CA (1) CA1226223A (es)
CS (1) CS249124B2 (es)
CY (1) CY1450A (es)
DD (1) DD202876A5 (es)
DE (1) DE3270116D1 (es)
DK (1) DK362482A (es)
ES (3) ES514947A0 (es)
FI (1) FI822813A7 (es)
GR (1) GR76267B (es)
HK (1) HK2189A (es)
HU (1) HU190408B (es)
IE (1) IE54215B1 (es)
IL (1) IL66340A (es)
IS (1) IS1360B6 (es)
MY (1) MY8700139A (es)
NO (1) NO822686L (es)
NZ (1) NZ201538A (es)
OA (1) OA07182A (es)
PH (1) PH18635A (es)
PT (1) PT75420B (es)
ZA (1) ZA825106B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
DE3216843C2 (de) * 1982-05-05 1986-10-23 Ludwig Heumann & Co GmbH, 8500 Nürnberg 3-Thiomethyl-pyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
HU195220B (en) * 1983-05-03 1988-04-28 Byk Gulden Lomberg Chem Fqb Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
CA1259070A (en) * 1983-07-01 1989-09-05 Upjohn Company (The) Substituted 2-¬monoannelated(3,4-,4,5-, and 5,6-)- pyridylalkylenesulfinyl|-benzimidazoles
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8404065D0 (sv) * 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
JO1406B1 (en) * 1984-11-02 1986-11-30 سميث كلاين اند فرينش لابوراتوريز ليمتد Chemical compounds
GB8526154D0 (en) * 1985-02-06 1985-11-27 Kotobuki Seiyaku Co Ltd 2-substituted cyclo-heptoimidazoles
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
AR243167A1 (es) * 1985-08-24 1993-07-30 Hoechst Ag Procedimiento para la preparacion de toluidinas sustituidas.
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
EP0786461A1 (en) * 1986-11-13 1997-07-30 Eisai Co., Ltd. Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same
JP2718945B2 (ja) * 1987-06-17 1998-02-25 エーザイ株式会社 ピリジン誘導体及びそれを含有する潰瘍治療剤
FI96860C (fi) * 1987-06-17 1996-09-10 Eisai Co Ltd Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi
US5223515A (en) * 1988-08-18 1993-06-29 Takeda Chemical Industries, Ltd. Injectable solution containing a pyridyl methylsulfinylbenzimidazole
AT394368B (de) * 1990-08-07 1992-03-25 Byk Gulden Lomberg Chem Fab Verfahren zur herstellung von 3,4-dialkoxypyridinen
WO1993024480A1 (fr) * 1992-06-01 1993-12-09 Yoshitomi Pharmaceutical Industries, Ltd. Compose de pyridine et son utilisation medicinale
US5504082A (en) * 1992-06-01 1996-04-02 Yoshitomi Pharmaceutical Industries, Ltd. Pyridine compound and pharmaceutical compostions
US5387600A (en) * 1992-07-30 1995-02-07 Fuji Photo Film Co., Ltd. Treating arteriosclerosis using benzimidazole compositions
CA2175235A1 (en) * 1993-10-29 1995-05-04 Takeshi Kawakita Pyridine compound and medicinal use thereof
EP0788795B1 (en) * 1994-06-10 2002-11-13 Nauchno-Issledovatelsky Institut Farmakologii Akademii Meditsinskikh Nauk Pharmacologically active 2-mercaptobenzimidazole derivatives
US7230014B1 (en) 1997-10-14 2007-06-12 Eisai Co., Ltd. Pharmaceutical formulation comprising glycine as a stabilizer
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
DE10140492A1 (de) 2001-08-17 2003-08-14 Gruenenthal Gmbh Hydrate von gegebenenfalls substituierten 2-(2-Pyridinyl)methylthio-1H-benzimidazolen und Verfahren zu ihrer Herstellung
RU2215739C1 (ru) * 2002-04-03 2003-11-10 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" Способ получения 5-метокси-2-(4-метокси-3,5-диметил-2-пиридилметилтио)бензимидазола
EP2264025B1 (en) 2004-09-13 2013-11-06 Takeda Pharmaceutical Company Limited Method for producing lansoprazole
SI2003130T1 (sl) 2006-03-10 2012-02-29 Arigen Pharmaceuticals Inc Nov piridinski derivat, ki ima aktivnost proti Helicobacter pylori
AU2007317561A1 (en) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same
US8778975B2 (en) 2006-12-18 2014-07-15 Link Geonomics, Inc. Helicobacter pylori eradicating agent having inhibitory activity on gastric acid secretion
AU2009215514B9 (en) 2008-02-20 2014-01-30 The Curators Of The University Of Missouri Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same
EP2420500A4 (en) * 2009-04-09 2012-09-05 Arigen Pharmaceuticals Inc PYRIDINTHIODERIVATE AND PHARMACEUTICAL COMPOSITION THEREOF AND WITH ANTI-HELIDOBACTER PYLORI EFFECT
US8722026B2 (en) 2010-01-06 2014-05-13 Elc Management, Llc Skin lightening compositions
AU2013267022B2 (en) * 2010-01-06 2016-04-21 Elc Management Llc Skin lightening compositions
US8992897B2 (en) * 2010-01-06 2015-03-31 Elc Management Llc Skin lightening compositions
KR102409502B1 (ko) * 2016-09-14 2022-06-16 위펑 제인 쳉 D-아미노산 옥시다제 (daao) 저해제로서 신규한 치환된 벤즈이미다졸 유도체

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7112208A (es) * 1971-09-04 1973-03-06
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (es) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects

Also Published As

Publication number Publication date
ES523344A0 (es) 1984-10-01
JPS5839622A (ja) 1983-03-08
CY1450A (en) 1989-03-10
FI822813L (fi) 1983-02-14
MY8700139A (en) 1987-12-31
ES8401482A1 (es) 1983-12-16
IE54215B1 (en) 1989-07-19
PT75420A (en) 1982-09-01
DE3270116D1 (en) 1986-04-30
ES514947A0 (es) 1983-12-16
US4746667A (en) 1988-05-24
CS249124B2 (en) 1987-03-12
IS1360B6 (is) 1989-05-25
ZA825106B (en) 1983-04-27
JPH0313203B2 (es) 1991-02-22
NZ201538A (en) 1985-12-13
FI822813A7 (fi) 1983-02-14
FI822813A0 (fi) 1982-08-12
OA07182A (fr) 1984-04-30
ES532044A0 (es) 1984-12-16
KR880001714B1 (ko) 1988-09-08
IL66340A0 (en) 1982-11-30
DK362482A (da) 1983-02-14
DD202876A5 (de) 1983-10-05
IS2749A7 (is) 1983-02-14
AU8697882A (en) 1983-02-17
NO822686L (no) 1983-02-14
EP0074341B1 (en) 1986-03-26
KR840001156A (ko) 1984-03-28
GR76267B (es) 1984-08-04
IE821940L (en) 1983-02-13
ES8502109A1 (es) 1984-12-16
EP0074341A1 (en) 1983-03-16
PH18635A (en) 1985-08-23
HU190408B (en) 1986-09-29
PT75420B (en) 1986-12-09
CA1226223A (en) 1987-09-01
HK2189A (en) 1989-01-20
ATE18765T1 (de) 1986-04-15
AU556736B2 (en) 1986-11-20
IL66340A (en) 1986-08-31

Similar Documents

Publication Publication Date Title
ES8500265A1 (es) Un procedimiento de preparacion de derivados de bencimidazol (divisional de la patente de invencion num. 514.947, presentada el 12 de agosto 1982)
PH23739A (en) Piperidine derivative and pharmaceutical composition
ES8706664A1 (es) Procedimiento para preparar compuestos carbostirilicos
DE2960820D1 (en) Carbostyrile derivatives, processes for their preparation and pharmaceutical compositions containing them
ES8301967A1 (es) Procedimiento de preparar compuestos carbostirilicos.
IE812683L (en) Thieno-pyridine derivatives
IL71788A0 (en) Pyridazinones,processes for their preparation and pharmaceutical compositions containing the same
ES8203870A1 (es) Procedimiento para preparar difenilbutil-1-acilpiperazinas
IL48453A (en) Substituted 6-oxa-1-azatricyclo-(6.2.2.0 )dodecan-5-ones and 1,4-ethano-5-oxo octa (or decahydro)quinoline,their preparation and pharmaceutical compositions containing them
ES8801637A1 (es) Un procedimiento para la preparacion de benzimidazoles.
ES8305336A1 (es) "un metodo de preparar una 4-ariloxi-1,2,3,4-tetrahidroisoquinoleina".
HK47592A (en) Piperazine derivatives
ES8206550A1 (es) Un procedimiento para la preparacion de derivados de 2-desoxi-3-5-di-o-alquilcarbonil-5-fluorurina.
JPS5772981A (en) 1,8-naphthyridine derivative and its salt
HK47492A (en) Piperazine derivatives
JPS5782314A (en) Carcinostatic agent
JPS5473797A (en) Pyride 3.2.1-jk carbazole derivative
IE56310B1 (en) Acridanone derivatives
JPS5246083A (en) Preparation of 3-amino-4-hyaroxycarbostyrils
JPS56133260A (en) Azetidine derivative and its preparation
JPS5384991A (en) Novel nitrogen-containing heterocyclic compound and its preparation

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990401