[go: up one dir, main page]

ES8404311A1 - Un procedimiento para la preparacion de derivados de etanolamina. - Google Patents

Un procedimiento para la preparacion de derivados de etanolamina.

Info

Publication number
ES8404311A1
ES8404311A1 ES520690A ES520690A ES8404311A1 ES 8404311 A1 ES8404311 A1 ES 8404311A1 ES 520690 A ES520690 A ES 520690A ES 520690 A ES520690 A ES 520690A ES 8404311 A1 ES8404311 A1 ES 8404311A1
Authority
ES
Spain
Prior art keywords
straight
branched
hydrogen
alkyl
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520690A
Other languages
English (en)
Other versions
ES520690A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES520690A0 publication Critical patent/ES520690A0/es
Publication of ES8404311A1 publication Critical patent/ES8404311A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/52—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition by dehydration and rearrangement involving two hydroxy groups in the same molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ETANOLAMINA, DE FORMULA GENERAL (I), EN LA QUE R ES HIDROGENO O METILO; R ES HIDROGENO O METILO; R ES FENILO; R ES HIDROGENO, HALOGENO, HIDROXI O ALQUILO INFERIOR; R ES UN RESTO; Y N ES 1 O 2, Y SUS SALES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN LAS QUE R, R, R, R, R Y N TIENEN LOS SIGNIFICADOS YA MENCIONADOS.DE APLICACION EN FARMACIA POR SU ACTIVIDAD ANTI-OBESIDAD Y ANTI-HIPERGLICEMICA.
ES520690A 1981-07-11 1983-03-16 Un procedimiento para la preparacion de derivados de etanolamina. Expired ES8404311A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8121442 1981-07-11
GB8139024 1981-12-30

Publications (2)

Publication Number Publication Date
ES520690A0 ES520690A0 (es) 1984-05-01
ES8404311A1 true ES8404311A1 (es) 1984-05-01

Family

ID=26280094

Family Applications (3)

Application Number Title Priority Date Filing Date
ES513967A Expired ES8308835A1 (es) 1981-07-11 1982-07-12 Un procedimiento para la preparacion de derivados de etanola-mina.
ES520690A Expired ES8404311A1 (es) 1981-07-11 1983-03-16 Un procedimiento para la preparacion de derivados de etanolamina.
ES520691A Expired ES8404312A1 (es) 1981-07-11 1983-03-16 Un procedimiento para la preparacion de derivados de etanolamina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES513967A Expired ES8308835A1 (es) 1981-07-11 1982-07-12 Un procedimiento para la preparacion de derivados de etanola-mina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES520691A Expired ES8404312A1 (es) 1981-07-11 1983-03-16 Un procedimiento para la preparacion de derivados de etanolamina.

Country Status (5)

Country Link
EP (1) EP0070133B1 (es)
AU (1) AU553070B2 (es)
DE (1) DE3271132D1 (es)
ES (3) ES8308835A1 (es)
NZ (1) NZ201217A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1258454A (en) * 1982-08-10 1989-08-15 Leo Alig Phenethanolamines
GB8310556D0 (en) * 1983-04-19 1983-05-25 Beecham Group Plc Compounds
GB8415377D0 (en) * 1984-06-15 1984-07-18 Beecham Group Plc Compounds
GB8528633D0 (en) 1985-11-21 1985-12-24 Beecham Group Plc Compounds
CA1287061C (en) * 1986-06-27 1991-07-30 Roche Holding Ltd. Pyridine ethanolamine derivatives
DE3631009A1 (de) * 1986-09-12 1988-03-24 Bayer Ag Arylethanolamine, verfahren zu ihrer herstellung und ihre verwendung zur leistungsfoerderung
GB8910374D0 (en) * 1989-05-05 1989-06-21 Ici Plc Chemical compounds
GB9207964D0 (en) * 1992-04-10 1992-05-27 Ici Plc Chemical compounds
US5563171A (en) * 1993-11-05 1996-10-08 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists
US5578638A (en) * 1993-11-05 1996-11-26 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists
US6451814B1 (en) * 2000-07-17 2002-09-17 Wyeth Heterocyclic β-3 adrenergic receptor agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006735B1 (en) * 1978-06-28 1983-06-15 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
IL57671A (en) * 1978-07-03 1982-11-30 Lilly Co Eli Phenethanolamines,process for their preparation and pharmaceutical and animal feed compositions containing the same
ATE1994T1 (de) * 1979-06-16 1982-12-15 Beecham Group Plc Aethanamin-derivate, ihre herstellung und verwendung in pharmazeutischen zusammensetzungen.
ATE14222T1 (de) * 1979-11-15 1985-07-15 Beecham Group Plc Sekundaere aethanolamine, ihre herstellung und ihre verwendung in pharmazeutischen zusammensetzungen.
DE3169094D1 (en) * 1980-11-20 1985-03-28 Beecham Group Plc Secondary amines

Also Published As

Publication number Publication date
ES513967A0 (es) 1983-08-01
ES520690A0 (es) 1984-05-01
NZ201217A (en) 1986-05-09
ES520691A0 (es) 1984-05-01
ES8308835A1 (es) 1983-08-01
EP0070133B1 (en) 1986-05-14
EP0070133A3 (en) 1983-05-18
ES8404312A1 (es) 1984-05-01
EP0070133A2 (en) 1983-01-19
DE3271132D1 (en) 1986-06-19
AU553070B2 (en) 1986-07-03
AU8579082A (en) 1983-01-20

Similar Documents

Publication Publication Date Title
DE3677452D1 (de) Chinazolinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE3070912D1 (en) Pharmaceutical heterocyclic compounds, processes for their preparation and compositions containing them
DE69122941D1 (de) Piperazinderivate
ES8308835A1 (es) Un procedimiento para la preparacion de derivados de etanola-mina.
SE7704783L (sv) Medel for separationsendamal och forfarande for dess framstellning
KR900000351A (ko) 1-아릴-나프토일아민 및 그의 제조방법
MY100115A (en) Nitrogen containing heterocyclic compounds, and their production and use.
MY102081A (en) 1,3-oxazolidine-2-one derivatives and processes for their preparation
JPS56103168A (en) Thiazole derivative, its preparation, and antihistaminic agent containing the same
MX11866A (es) Nuevas cicloalquilamidas y procedimiento para su preparacion.
ES8308543A1 (es) "procedimiento para la preparacion de nuevas 2-fenil-2-(piridiloxi)-etilaminas sustituidas".
NO940026L (no) Mono- og bis alkylamino-antracykliner
ES481551A1 (es) Procedimiento de preparacion de nuevos compuestos bis (ari- loxicarboxilicos).
ES467069A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1-3-bencenodimetanol
KR900016178A (ko) 2-치환 n,n'-디트리메톡시벤조일 피페라진, 그의 제조 방법 및 그를 함유하는 치료 조성물
ES488988A0 (es) Un metodo de preparar derivados de fenil-piperazina farma- ceuticamente activos
ES8405020A1 (es) Un procedimiento para la preparacion de derivados de fosfolipidos.
ES8401456A1 (es) Procedimiento para la preparacion de 2-aminometilfenoles.
ES556048A0 (es) Un procedimiento para la preparacion de un derivado de tiazolidina.
SE7910387L (sv) 7alfa-metoxicefalosporinderivat och forfarande for framstellning derav
ATE96026T1 (de) Verwendung heterozyklischer amide zur verhinderung der tumormetastasierung.
ES2059685T3 (es) Acilaminoalquilpiridinamidas inhibidoras de metastasis tumoral.
NO903084L (no) Farmasoeytisk anvendbare thiazolderivater og fremgangsmaatefor deresfremstilling.
ATE19629T1 (de) N-substituierte derivate des tetrahydroisophthalimids.
DK601883A (da) Phenyl-propanolderivater