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ES8402829A1 - Procedimiento para la preparacion de derivados de tiazolina. - Google Patents

Procedimiento para la preparacion de derivados de tiazolina.

Info

Publication number
ES8402829A1
ES8402829A1 ES518271A ES518271A ES8402829A1 ES 8402829 A1 ES8402829 A1 ES 8402829A1 ES 518271 A ES518271 A ES 518271A ES 518271 A ES518271 A ES 518271A ES 8402829 A1 ES8402829 A1 ES 8402829A1
Authority
ES
Spain
Prior art keywords
preparation
derivatives
tiazoline
procedure
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518271A
Other languages
English (en)
Other versions
ES518271A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES518271A0 publication Critical patent/ES518271A0/es
Publication of ES8402829A1 publication Critical patent/ES8402829A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE TIAZOLINA.CONSISTE EN SOMETER A UNA REACCION DE DESHIDRATACION, MEDIANTE CATALISIS PROTONICA COMPUESTOS DE FORMULA (II), EN PRESENCIA DE DISOLVENTE ORGANICO POLAR O EN PRESENCIA DE UNA MEZCLA DE AGUA Y DISOLVENTE ORGANICO POLAR PARA DAR COMPUESTOS DE FORMULA (I), Y POSTERIORMENTE TRANSFORMAR EL COMPUESTOS DE FORMULA (I) EN SUS SALES POR ADICION DE ACIDOS ORGANICOS O INORGANICOS DE FORMULA GENERAL H-A. EL CATALIZADOR EMPLEADO PUEDE SER UN ACIDO CARBOXILICO ALIFATICO, LOS DISOLVENTES UTILIZADOS SON METANOL, ETANOL, PROPANOLY OTROS, Y LAS TEMPERATURAS DE REACCION ESTAN COMPRENDIDAS ENTRE 0 Y 200JC.TIENE APLICACIONES FARMACOLOGICAS POR SU EFECTO FAVORABLE SOBRE LAS LIPOPROTEINAS DEL SUERO.
ES518271A 1980-12-30 1982-12-16 Procedimiento para la preparacion de derivados de tiazolina. Expired ES8402829A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803049460 DE3049460A1 (de) 1980-12-30 1980-12-30 "thiazolinderivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen

Publications (2)

Publication Number Publication Date
ES518271A0 ES518271A0 (es) 1984-02-16
ES8402829A1 true ES8402829A1 (es) 1984-02-16

Family

ID=6120529

Family Applications (5)

Application Number Title Priority Date Filing Date
ES508293A Granted ES508293A0 (es) 1980-12-30 1981-12-23 "procedimiento para la preparacion de derivados de tiazolina".
ES518271A Expired ES8402829A1 (es) 1980-12-30 1982-12-16 Procedimiento para la preparacion de derivados de tiazolina.
ES518272A Granted ES518272A0 (es) 1980-12-30 1982-12-16 Procedimiento para la preparacion de derivados de tiazolina.
ES518273A Granted ES518273A0 (es) 1980-12-30 1982-12-16 Procedimiento para la preparacion de derivados de tiazolina.
ES518274A Granted ES518274A0 (es) 1980-12-30 1982-12-16 Procedimiento para la preparacion de derivados de tiazolina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES508293A Granted ES508293A0 (es) 1980-12-30 1981-12-23 "procedimiento para la preparacion de derivados de tiazolina".

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES518272A Granted ES518272A0 (es) 1980-12-30 1982-12-16 Procedimiento para la preparacion de derivados de tiazolina.
ES518273A Granted ES518273A0 (es) 1980-12-30 1982-12-16 Procedimiento para la preparacion de derivados de tiazolina.
ES518274A Granted ES518274A0 (es) 1980-12-30 1982-12-16 Procedimiento para la preparacion de derivados de tiazolina.

Country Status (17)

Country Link
US (1) US4421757A (es)
EP (1) EP0055458B1 (es)
JP (1) JPS57134472A (es)
KR (1) KR830007601A (es)
AR (2) AR231134A1 (es)
AT (1) ATE11778T1 (es)
AU (1) AU542670B2 (es)
CA (1) CA1173836A (es)
DE (2) DE3049460A1 (es)
DK (1) DK581181A (es)
ES (5) ES508293A0 (es)
FI (1) FI814175A7 (es)
HU (1) HU184976B (es)
IE (1) IE52259B1 (es)
IL (1) IL64653A (es)
NO (1) NO154551B (es)
ZA (1) ZA818968B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761422A (en) * 1986-11-20 1988-08-02 Lusofarmaco Istituto Lusofarmaco D'italia Spa (2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same
US6353006B1 (en) 1999-01-14 2002-03-05 Bayer Corporation Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
TR200102041T2 (tr) * 1999-01-14 2001-12-21 Bayer Corporation Progesteron reseptör bağlama aktif maddeleri olarak ikameli 2-arilimino heterosaykıllar
FR2796643B1 (fr) * 1999-07-22 2005-04-29 Sod Conseils Rech Applic Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique
FR2819508B1 (fr) * 2001-01-12 2005-01-21 Sod Conseils Rech Applic Derives de 2-arylimino-2, 3-dihydorthiazoles, leurs procedes de preparation et leur utilisation therapeutiques
CN1247553C (zh) 1999-09-14 2006-03-29 盐野义制药株式会社 2－亚氨基－1,3－噻嗪衍生物
US7271195B2 (en) 2003-06-10 2007-09-18 Kalypsys, Inc. Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease
AU2004247136A1 (en) * 2003-06-10 2004-12-23 Kalypsys, Inc. Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2436263C2 (de) * 1974-07-27 1983-02-17 Hoechst Ag, 6000 Frankfurt Thiazolidinderivate und Verfahren zu ihrer Herstellung
DE2533821A1 (de) * 1975-07-29 1977-02-17 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
DE2546165A1 (de) * 1975-10-15 1977-04-28 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
SE7700436L (sv) * 1976-01-17 1977-07-18 Hoechst Ag Tiazolidinderivat och forfarande for deras framstellning
DE2926771A1 (de) * 1979-07-03 1981-01-15 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
ES8308551A1 (es) 1983-09-01
JPS57134472A (en) 1982-08-19
IE52259B1 (en) 1987-08-19
ES8308549A1 (es) 1983-09-01
AR231978A1 (es) 1985-04-30
KR830007601A (ko) 1983-11-04
ES518271A0 (es) 1984-02-16
NO814468L (no) 1982-07-01
AR231134A1 (es) 1984-09-28
ATE11778T1 (de) 1985-02-15
IE813057L (en) 1982-06-30
AU542670B2 (en) 1985-02-28
EP0055458A2 (de) 1982-07-07
IL64653A (en) 1985-09-29
ZA818968B (en) 1982-11-24
EP0055458A3 (en) 1982-10-20
EP0055458B1 (de) 1985-02-13
FI814175L (fi) 1982-07-01
DE3049460A1 (de) 1982-07-29
DK581181A (da) 1982-07-01
FI814175A7 (fi) 1982-07-01
IL64653A0 (en) 1982-03-31
ES8305342A1 (es) 1983-04-01
ES8308550A1 (es) 1983-09-01
NO154551B (no) 1986-07-07
ES518274A0 (es) 1983-09-01
HU184976B (en) 1984-11-28
ES508293A0 (es) 1983-04-01
CA1173836A (en) 1984-09-04
ES518272A0 (es) 1983-09-01
US4421757A (en) 1983-12-20
AU7906881A (en) 1982-07-08
DE3168978D1 (en) 1985-03-28
ES518273A0 (es) 1983-09-01

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