ES8401952A1 - Un procedimiento para preparar nuevos derivados de 1,4-benzotiazina. - Google Patents
Un procedimiento para preparar nuevos derivados de 1,4-benzotiazina.Info
- Publication number
- ES8401952A1 ES8401952A1 ES518247A ES518247A ES8401952A1 ES 8401952 A1 ES8401952 A1 ES 8401952A1 ES 518247 A ES518247 A ES 518247A ES 518247 A ES518247 A ES 518247A ES 8401952 A1 ES8401952 A1 ES 8401952A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- processes
- preparation
- aryl
- benzothiazine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UJVBZCCNLAAMOV-UHFFFAOYSA-N 2h-1,2-benzothiazine Chemical class C1=CC=C2C=CNSC2=C1 UJVBZCCNLAAMOV-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004367 cycloalkylaryl group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 1,4-BENZOTIAZINA, DE FORMULA GENERAL (I), EN LA QUE R ES ALQUILO INFERIOR QUE PUEDE TENER UNO O MAS SUSTITUYENTES SELECCIONADOS ENTRE CARBOXI, ARILO Y CARBOXI; R ES HIDROGENO, ALQUILO INFERIOR, AMINO O ARILO; R ES HIDROGENO, HALOGENO, ALQUILO INFERIOR O ALCOXI INFERIOR; Y N ES 0, 1 O 2, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN LA QUE R, R Y N TIENEN LOS SIGNIFICADOS YA INDICADOS, CON UN ISOCIANATO DE FORMULA: OCN-R, EN LA QUE R TIENE EL SIGNIFICADO YA INDICADO.DEAPLICACION EN EL TRATAMIENTO DE ENFERMEDADES AUTOINMUNES POR SUS EFECTOS TERAPEUTICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8041520 | 1980-12-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES518247A0 ES518247A0 (es) | 1984-01-01 |
| ES8401952A1 true ES8401952A1 (es) | 1984-01-01 |
Family
ID=10518252
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508415A Expired ES8304956A1 (es) | 1980-12-30 | 1981-12-29 | Un procedimiento para preparar nuevos derivados de 1,4-benzotiazina. |
| ES518247A Expired ES8401952A1 (es) | 1980-12-30 | 1982-12-15 | Un procedimiento para preparar nuevos derivados de 1,4-benzotiazina. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508415A Expired ES8304956A1 (es) | 1980-12-30 | 1981-12-29 | Un procedimiento para preparar nuevos derivados de 1,4-benzotiazina. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4397849A (es) |
| EP (1) | EP0055917B1 (es) |
| JP (1) | JPS57131775A (es) |
| AT (1) | ATE10370T1 (es) |
| DE (1) | DE3167347D1 (es) |
| ES (2) | ES8304956A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5922022A (ja) * | 1982-07-27 | 1984-02-04 | Hoya Corp | ビ−ムスプリツタ− |
| NO832663L (no) * | 1982-08-04 | 1984-02-06 | Bayer Ag | 4h-1,4-benzothiazin-derivat, fremgangsmaate til deres fremstilling og deres anvendelse som laegemiddel, fortilsetningsstoffer og konserveringsmiddel |
| DE3229121A1 (de) * | 1982-08-04 | 1984-02-09 | Bayer Ag, 5090 Leverkusen | 4h-1,4-benzothiazine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US11084796B2 (en) * | 2016-05-10 | 2021-08-10 | Georgia State University Research Foundation, Inc. | Heterocyclic derivatives for the treatment of RSV |
| US10906899B2 (en) | 2016-05-10 | 2021-02-02 | Georgia State University Research Foundation, Inc. | Bicyclic fused pyrazole derivatives for the treatment of RSV |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2863864A (en) * | 1958-12-09 | Chchjconh- | ||
| CA603132A (en) * | 1960-08-09 | Sterling Drug Inc. | 3-oxo-3,4-dihydro-1,4,2-benzothiazine-2-acetic acid hydrazides | |
| FR1438225A (fr) | 1964-09-24 | 1966-05-13 | Centre Nat Rech Scient | Dérivés de la benzothiazine et leur préparation |
| US3715353A (en) | 1970-10-12 | 1973-02-06 | Squibb & Sons Inc | (aminoalkoxy-benzylidene)-2h-benzothiazine-3(4h)-ones and related compounds |
| US3984405A (en) | 1971-06-28 | 1976-10-05 | E. R. Squibb & Sons, Inc. | Anti-inflammatory agents |
| US4268301A (en) | 1978-04-17 | 1981-05-19 | Sumitomo Chemical Company, Limited | 1,4-Benzothiazines |
| DE2912445A1 (de) * | 1979-03-29 | 1980-10-09 | Thiemann Chem Pharm Fab | 2-methylen-2,3-dihydro-3-oxo-4h-1,4- benzothiazin-1,1-dioxid-verbindungen, ihre herstellung und verwendung |
-
1981
- 1981-12-11 US US06/329,862 patent/US4397849A/en not_active Expired - Fee Related
- 1981-12-22 EP EP81306058A patent/EP0055917B1/en not_active Expired
- 1981-12-22 AT AT81306058T patent/ATE10370T1/de not_active IP Right Cessation
- 1981-12-22 DE DE8181306058T patent/DE3167347D1/de not_active Expired
- 1981-12-25 JP JP57000141A patent/JPS57131775A/ja active Pending
- 1981-12-29 ES ES508415A patent/ES8304956A1/es not_active Expired
-
1982
- 1982-12-15 ES ES518247A patent/ES8401952A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ATE10370T1 (de) | 1984-12-15 |
| ES508415A0 (es) | 1983-03-16 |
| ES518247A0 (es) | 1984-01-01 |
| DE3167347D1 (en) | 1985-01-03 |
| EP0055917B1 (en) | 1984-11-21 |
| EP0055917A1 (en) | 1982-07-14 |
| US4397849A (en) | 1983-08-09 |
| JPS57131775A (en) | 1982-08-14 |
| ES8304956A1 (es) | 1983-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19851015 |