[go: up one dir, main page]

ES8401057A1 - Pharmaceutically-active pyridylvinylpyridazinones. - Google Patents

Pharmaceutically-active pyridylvinylpyridazinones.

Info

Publication number
ES8401057A1
ES8401057A1 ES517334A ES517334A ES8401057A1 ES 8401057 A1 ES8401057 A1 ES 8401057A1 ES 517334 A ES517334 A ES 517334A ES 517334 A ES517334 A ES 517334A ES 8401057 A1 ES8401057 A1 ES 8401057A1
Authority
ES
Spain
Prior art keywords
alcoxy
alkyl
compound
formula
substitute
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517334A
Other languages
Spanish (es)
Other versions
ES517334A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES8401057A1 publication Critical patent/ES8401057A1/en
Publication of ES517334A0 publication Critical patent/ES517334A0/en
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Detergent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE PIRIDAZINONA.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), DON DE PY ES UN GRUPO 2-,3-, O 4-PIRIDILO QUE ESTA INSUSTITUIDO O QUE LLEVA UNO O DOS SUSTITUYENTES ELEGIDOS ENTRE HALOGENO, CIANO, HIDROXIMETILO, CARBOXI, CARBAMOILO Y ALQUILO, ALCOXI, ALCOXI-CARBONILO, ALQUILCARBAMOILO Y DIALQUILCARBAMOILO EN DONDE CADA ALQUILO O ALCOXI TIENE HASTA 4 ATOMOS DE CARBONO, O QUE LLEVA UN SUSTITUYENTE OXIGENO BIEN COMO UN N-OXIDO O COMO UN SUSTITUYENTE OXO, EN EL ATOMO DE CARBONO 2 O 4; O UNA SALDE ADICION DE ACIDO DEL MISMO; CON HIDRAZINA, PREFERIBLEMENTE, EN UN DISOLVENTE, TAL COMO METANOL, A LA TEMPERATURA DE LABORATORIO, PARA DAR UN COMPUESTO DE FORMULA (I), DONDE PY TIENE EL MISMO SIGNIFICADO QUE EN (II).DE APLICACION FARMACOLOGICA POR SUS PROPIEDADES CARDIOTONICAS Y/O ANTIHIPERTENSIVAS.PROCEDURE FOR PREPARING PYRIDAZINONE DERIVATIVES. CONSISTS IN THE REACTION OF A COMPOUND OF FORMULA (II), WHERE PY IS A 2-,3-, OR 4-PYRIDILO GROUP WHICH IS UNSUBSTITUTED OR BEARS ONE OR TWO SUBSTITUENTS CHOSEN FROM HALOGEN, CYANO, HYDROXYMETHYL, CARBOXY, CARBAMOYL AND ALKYL, ALCOXY, ALCOXY-CARBONYL, ALKYLCARBAMOYL AND DALKYLCARBAMOYL IN WHICH EACH ALKYL OR ALCOXY HAS UP TO 4 CARBON ATOMS, OR CARRYING AN OXYGEN SUBSTITUTE, EITHER AS AN N-OXIDE OR AS AN OXO SUBSTITUTE, IN THE CARBON ATOM 2 OR 4; OR AN ADDITIONAL SALT OF ACID THEREOF; WITH HYDRAZINE, PREFERABLY, IN A SOLVENT, SUCH AS METHANOL, AT LABORATORY TEMPERATURE, TO GIVE A COMPOUND OF FORMULA (I), WHERE PY HAS THE SAME MEANING AS IN (II). OR ANTIHYPERTENSIVE.

ES517334A 1981-11-12 1982-11-12 PROCEDURE FOR PREPARING PIRIDAZINONE DERIVATIVES. Granted ES517334A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8134177 1981-11-12

Publications (2)

Publication Number Publication Date
ES8401057A1 true ES8401057A1 (en) 1983-12-01
ES517334A0 ES517334A0 (en) 1983-12-01

Family

ID=10525838

Family Applications (1)

Application Number Title Priority Date Filing Date
ES517334A Granted ES517334A0 (en) 1981-11-12 1982-11-12 PROCEDURE FOR PREPARING PIRIDAZINONE DERIVATIVES.

Country Status (20)

Country Link
US (1) US4508721A (en)
EP (1) EP0081906B1 (en)
JP (1) JPS5890581A (en)
AT (1) ATE14430T1 (en)
AU (1) AU555858B2 (en)
CA (1) CA1189862A (en)
DE (1) DE3264939D1 (en)
DK (1) DK483282A (en)
ES (1) ES517334A0 (en)
FI (1) FI73991C (en)
GR (1) GR77366B (en)
HU (1) HU188221B (en)
IE (1) IE54598B1 (en)
IL (1) IL67184A (en)
MY (1) MY8700460A (en)
NO (1) NO159489C (en)
NZ (1) NZ202473A (en)
PT (1) PT75826B (en)
YU (1) YU292882A (en)
ZA (1) ZA827724B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3321012A1 (en) * 1983-06-10 1984-12-13 A. Nattermann & Cie GmbH, 5000 Köln SUBSTITUTED 4,5-DIHYDRO-6- (THIEN-2-YL) -3 (2H) -PYRIDAZINONE AND 6- (THIEN-2-YL) -3 (2H) -PYRIDAZINONE AND METHOD FOR THE PRODUCTION THEREOF
GB8323553D0 (en) * 1983-09-02 1983-10-05 Smith Kline French Lab Pharmaceutical compositions
JPS60126282A (en) * 1983-12-14 1985-07-05 Mitsubishi Chem Ind Ltd Pyridazinone derivatives or salts thereof
JPS60197672A (en) * 1984-03-16 1985-10-07 Mitsubishi Chem Ind Ltd Viridazinone derivatives or their salts
US4631279A (en) * 1984-10-15 1986-12-23 Eli Lilly And Company 6-(pyridinylphenyl)dihydropyridazinones as inotropic agents
US4656170A (en) * 1985-05-28 1987-04-07 Warner-Lambert Company N-[4-[2-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)ethenyl]phenyl]acetamide and related compounds
DE3650717T2 (en) * 1985-12-13 1999-09-16 Canon K.K., Tokio/Tokyo Image processing apparatus and method using blocks of compressed data

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298609A (en) * 1979-08-30 1981-11-03 Sterling Drug Inc. 4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol and salts, their preparation and use as blood pressure lowering agents
US4304777A (en) * 1979-08-30 1981-12-08 Sterling Drug Inc. 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics
US4346221A (en) * 1980-04-28 1982-08-24 Sterling Drug Inc. Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones

Also Published As

Publication number Publication date
IE822496L (en) 1983-05-12
NO823766L (en) 1983-05-13
AU8987282A (en) 1983-05-19
YU292882A (en) 1985-04-30
FI823896L (en) 1983-05-13
DE3264939D1 (en) 1985-08-29
EP0081906B1 (en) 1985-07-24
HU188221B (en) 1986-03-28
FI73991B (en) 1987-08-31
NO159489B (en) 1988-09-26
IL67184A (en) 1986-08-31
ATE14430T1 (en) 1985-08-15
DK483282A (en) 1983-05-13
GR77366B (en) 1984-09-11
FI73991C (en) 1987-12-10
ES517334A0 (en) 1983-12-01
NZ202473A (en) 1985-05-31
MY8700460A (en) 1987-12-31
AU555858B2 (en) 1986-10-09
CA1189862A (en) 1985-07-02
EP0081906A1 (en) 1983-06-22
US4508721A (en) 1985-04-02
IE54598B1 (en) 1989-12-06
NO159489C (en) 1989-01-04
FI823896A0 (en) 1982-11-12
ZA827724B (en) 1983-10-26
JPS5890581A (en) 1983-05-30
PT75826B (en) 1985-11-12
PT75826A (en) 1982-12-01

Similar Documents

Publication Publication Date Title
ES8707547A1 (en) PROCEDURE FOR PREPARING AN OLIGOPEPTIDIL-ARGININOL U-HOMOARGININOL OR DERIVED FROM THESE
ES8706146A1 (en) 5-(6-imidazo[1,2-a]pyridyl) pyridine derivative.
ES8304095A1 (en) Anti-tumor quinazoline compounds
KR830007635A (en) Method for preparing 4-amino-6,7-dimethoxy-2-piperazinoquinazoline derivative
ES8604179A1 (en) PROCEDURE FOR THE PREPARATION OF NEW TIAZO-LIDINIC DERIVATIVES
ES8202343A1 (en) A PROCEDURE FOR PREPARING IMIDAZO-PIRIDINAS
KR860003256A (en) Method for preparing N ^ 6-substituted deoxyribose analogs of adenosine
ES8401042A1 (en) A PROCEDURE FOR THE PREPARATION OF NEW TRIAZINE DERIVATIVES.
ES8801618A1 (en) A PROCEDURE FOR PREPARING ARYCYCLOBUTYL ALKYLAMINE DERIVATIVES
ES8401057A1 (en) Pharmaceutically-active pyridylvinylpyridazinones.
ES8602666A1 (en) PROCEDURE FOR OBTAINING N-OXIDE DERIVATIVES FROM PIRIDINE
ES8401034A1 (en) Quinoline derivatives.
ES8706683A1 (en) Dihydroimidazo not 1,2-a pyrimidine derivatives, methods of preparing said compounds and pharmaceutical compositions constaining said compounds
ES8706151A1 (en) 1-6-Naphthyridin-2(1H)-ones useful as cardiotonics.
ES8301229A1 (en) A PROCEDURE FOR THE PREPARATION OF 4- (4-IMIDAZOLIL) 2-SUBSTITUTED PIRIDINES.
ES8603835A1 (en) Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them.
AU2750484A (en) Substituted phenyl-2-(1h)-pyrimidinones
ES8606321A1 (en) Benzofuran derivatives, processes for preparing the same and antihypertensive agents containing the same.
SE7711853L (en) STABILIZED LIQUID COMPOSITIONS OF ENZYMES AND COENZYMES AND THEIR PREPARATION
ES8708139A1 (en) A PROCEDURE FOR THE PREPARATION OF TETRAHIDROIMIDAZOQUINAZOLINONAS.
ES8304099A1 (en) "PROCEDURE FOR THE PREPARATION OF 2-HYDROXY-3-AZOLYL PROPANE DERIVATIVES".
ES2057031T3 (en) NUCLEOSIDE COMPOUNDS OF 2'-METHYLIDENPIRIMIDINE, ITS USE AND METHOD FOR ITS PRODUCTION.
ES8601916A1 (en) Pyridazinone derivatives and their use as agricultural fungicides
KR840005107A (en) Method for preparing pyrimidion and acid addition salts thereof
ES8609219A1 (en) A PROCEDURE FOR PRODUCING A DIPHENYL METHYLIMINE DERIVATIVE