ES8306753A1 - "procedimiento para la preparacion de nuevos derivados de azepina". - Google Patents
"procedimiento para la preparacion de nuevos derivados de azepina".Info
- Publication number
- ES8306753A1 ES8306753A1 ES515728A ES515728A ES8306753A1 ES 8306753 A1 ES8306753 A1 ES 8306753A1 ES 515728 A ES515728 A ES 515728A ES 515728 A ES515728 A ES 515728A ES 8306753 A1 ES8306753 A1 ES 8306753A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- mono
- unsubstituted
- alkoxycarbonyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE AZEPINA Y DE SUS SALES CON ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE M Y N VALEN 1-3, SIENDO M+N=4; R PUEDE SER VARIOS TIPOS DE RADICALES; R ES AMINO; Y R ES CARBOXI. CONSISTE EN LA REACCION DE UNA AZEPINONA, EVENTUALMENTE FORMADA EN LA MEZCLA DE REACCION, DE FORMULA (II), EN LA QUE R , M Y N TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN COMPUESTO DE FORMULA NC-CH -COOH O CON SUS ESTERES. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA ENTRE 0 C Y 100 C.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813105858 DE3105858A1 (de) | 1981-02-18 | 1981-02-18 | "neue thieno-azepine, ihre herstellung und ihre verwendung als arzneimittel" |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8306753A1 true ES8306753A1 (es) | 1983-06-01 |
| ES515728A0 ES515728A0 (es) | 1983-06-01 |
Family
ID=6125118
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES509682A Granted ES509682A0 (es) | 1981-02-18 | 1982-02-17 | "procedimiento para la preparacion de nuevos derivados de azepina". |
| ES515728A Granted ES515728A0 (es) | 1981-02-18 | 1982-09-15 | "procedimiento para la preparacion de nuevos derivados de azepina". |
| ES515730A Granted ES515730A0 (es) | 1981-02-18 | 1982-09-15 | "procedimiento para la preparacion de nuevos derivados de azepina". |
| ES515729A Expired ES8306754A1 (es) | 1981-02-18 | 1982-09-15 | "procedimiento para la preparacion de nuevos derivados de azepina". |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES509682A Granted ES509682A0 (es) | 1981-02-18 | 1982-02-17 | "procedimiento para la preparacion de nuevos derivados de azepina". |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES515730A Granted ES515730A0 (es) | 1981-02-18 | 1982-09-15 | "procedimiento para la preparacion de nuevos derivados de azepina". |
| ES515729A Expired ES8306754A1 (es) | 1981-02-18 | 1982-09-15 | "procedimiento para la preparacion de nuevos derivados de azepina". |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4414225A (es) |
| EP (1) | EP0058341B1 (es) |
| JP (1) | JPS57150687A (es) |
| AR (1) | AR231983A1 (es) |
| AT (1) | ATE13298T1 (es) |
| AU (1) | AU547951B2 (es) |
| CA (1) | CA1171084A (es) |
| CS (1) | CS227039B2 (es) |
| DD (1) | DD202577A5 (es) |
| DE (2) | DE3105858A1 (es) |
| DK (1) | DK150157C (es) |
| ES (4) | ES509682A0 (es) |
| FI (1) | FI820509L (es) |
| GB (1) | GB2093030B (es) |
| GR (1) | GR76793B (es) |
| HU (1) | HU190984B (es) |
| IE (1) | IE52540B1 (es) |
| IL (1) | IL65051A (es) |
| NO (1) | NO157503C (es) |
| NZ (1) | NZ199759A (es) |
| PH (1) | PH17724A (es) |
| PL (1) | PL137354B1 (es) |
| PT (1) | PT74447B (es) |
| SU (1) | SU1091858A3 (es) |
| YU (1) | YU34982A (es) |
| ZA (1) | ZA821020B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4520025A (en) * | 1982-07-21 | 1985-05-28 | William H. Rorer, Inc. | Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
| DE3230696A1 (de) * | 1982-08-18 | 1984-02-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue thieno-thiazol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| GB8800891D0 (en) * | 1988-01-15 | 1988-02-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| GB8909132D0 (en) * | 1989-04-21 | 1989-06-07 | Lilly Industries Ltd | Pharmaceutical compounds |
| FR2652579B1 (fr) * | 1989-10-02 | 1992-01-24 | Sanofi Sa | Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique. |
| GB9025890D0 (en) * | 1990-11-28 | 1991-01-09 | Lilly Industries Ltd | Pharmaceutical compounds |
| US5532240A (en) * | 1991-12-26 | 1996-07-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Condensed thiophene compound and pharmaceutical use thereof |
| EP0596125A4 (en) * | 1991-12-26 | 1994-10-05 | Yoshitomi Pharmaceutical | Condensed thiophene compound and pharmaceutical use thereof. |
| US5334596A (en) * | 1993-05-11 | 1994-08-02 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| DE4324580A1 (de) * | 1993-07-22 | 1995-01-26 | Thomae Gmbh Dr K | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5696112A (en) * | 1995-01-17 | 1997-12-09 | American Cyanamid Company | Fused heterocyclic azepines as vasopressin antagonists |
| FR2733750B1 (fr) * | 1995-05-03 | 1997-06-13 | Synthelabo | Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique |
| US5939417A (en) * | 1998-10-19 | 1999-08-17 | Cell Pathways Inc | 1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia |
| SI1778243T1 (sl) * | 2004-06-30 | 2013-03-29 | Athersys, Inc. | Substituirani derivati azepina, kot modulatorji receptorja serotonina |
| DK1796663T3 (da) | 2004-09-03 | 2011-08-15 | Athersys Inc | Tricykliske heteroaryl-piperaziner, pyrrolidiner og azetidiner som serotonin-receptor-modulatorer |
| AU2007207508B2 (en) * | 2006-01-19 | 2011-08-18 | Athersys, Inc. | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof |
| WO2014100815A2 (en) | 2012-12-21 | 2014-06-26 | Abt Holding Company | Benzazepines as serotonin 5-ht2c receptor ligands and uses thereof |
| WO2014159067A1 (en) | 2013-03-13 | 2014-10-02 | Abt Holding Company | Thienylindole azepines as serotonin 5-ht2c receptor ligands and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3849441A (en) * | 1971-10-01 | 1974-11-19 | American Cyanamid Co | Substituted heterocyclic derivatives of azepine |
| US3758501A (en) * | 1971-10-01 | 1973-09-11 | M Weiss | Substituted heterocyclic derivatives of azepine |
| US3846446A (en) * | 1971-10-01 | 1974-11-05 | American Cyanamid Co | Substituted heterocyclic derivatives of azepine |
-
1981
- 1981-02-17 ZA ZA821020A patent/ZA821020B/xx unknown
- 1981-02-18 DE DE19813105858 patent/DE3105858A1/de not_active Withdrawn
-
1982
- 1982-02-03 EP EP82100745A patent/EP0058341B1/de not_active Expired
- 1982-02-03 AT AT82100745T patent/ATE13298T1/de not_active IP Right Cessation
- 1982-02-03 DE DE8282100745T patent/DE3263462D1/de not_active Expired
- 1982-02-11 SU SU823388045A patent/SU1091858A3/ru active
- 1982-02-12 US US06/348,496 patent/US4414225A/en not_active Expired - Fee Related
- 1982-02-15 GR GR67317A patent/GR76793B/el unknown
- 1982-02-16 FI FI820509A patent/FI820509L/fi not_active Application Discontinuation
- 1982-02-16 PH PH26951A patent/PH17724A/en unknown
- 1982-02-16 DD DD82237445A patent/DD202577A5/de unknown
- 1982-02-16 CA CA000396329A patent/CA1171084A/en not_active Expired
- 1982-02-17 YU YU00349/82A patent/YU34982A/xx unknown
- 1982-02-17 AU AU80552/82A patent/AU547951B2/en not_active Ceased
- 1982-02-17 NZ NZ199759A patent/NZ199759A/xx unknown
- 1982-02-17 JP JP57024249A patent/JPS57150687A/ja active Pending
- 1982-02-17 ES ES509682A patent/ES509682A0/es active Granted
- 1982-02-17 PT PT74447A patent/PT74447B/pt unknown
- 1982-02-17 DK DK069382A patent/DK150157C/da not_active IP Right Cessation
- 1982-02-17 NO NO820493A patent/NO157503C/no unknown
- 1982-02-17 GB GB8204585A patent/GB2093030B/en not_active Expired
- 1982-02-17 IE IE338/82A patent/IE52540B1/en unknown
- 1982-02-17 PL PL1982235121A patent/PL137354B1/pl unknown
- 1982-02-18 AR AR288469A patent/AR231983A1/es active
- 1982-02-18 CS CS821126A patent/CS227039B2/cs unknown
- 1982-02-18 HU HU82499A patent/HU190984B/hu unknown
- 1982-02-18 IL IL65051A patent/IL65051A/xx unknown
- 1982-09-15 ES ES515728A patent/ES515728A0/es active Granted
- 1982-09-15 ES ES515730A patent/ES515730A0/es active Granted
- 1982-09-15 ES ES515729A patent/ES8306754A1/es not_active Expired
Also Published As
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