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ES8304934A1 - Novel fluoro-prostacyclins - Google Patents

Novel fluoro-prostacyclins

Info

Publication number
ES8304934A1
ES8304934A1 ES510286A ES510286A ES8304934A1 ES 8304934 A1 ES8304934 A1 ES 8304934A1 ES 510286 A ES510286 A ES 510286A ES 510286 A ES510286 A ES 510286A ES 8304934 A1 ES8304934 A1 ES 8304934A1
Authority
ES
Spain
Prior art keywords
hydrogen
methyl
fluoro
agents
prostacyclins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES510286A
Other languages
Spanish (es)
Other versions
ES510286A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8304934A1 publication Critical patent/ES8304934A1/en
Publication of ES510286A0 publication Critical patent/ES510286A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Compounds of the formula < IMAGE > wherein one of the double bonds indicated by broken lines is present in 4,5 or 5,6-position, R is hydrogen or lower alkyl, R<1> is methyl, hydrogen or hydroxy R<2> is hydrogen, methyl or fluoro and R<21> is hydrogen, fluoro, trifluoromethyl or methyl with the proviso that when R<21> is trifluoromethyl, R<2> is hydrogen or methyl, their pharmaceutically acceptable salts, optical antipodes or racemates are useful as anti-secretory agents, anti-hypertensives, anti-ulcerogenic agents and blood platelet aggregation inhibiting agents.
ES510286A 1981-03-11 1982-03-10 "A PROCEDURE FOR THE PREPARATION OF NEW FLUORINE-PROSTACICLINES". Granted ES510286A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24281881A 1981-03-11 1981-03-11
US33779182A 1982-01-07 1982-01-07

Publications (2)

Publication Number Publication Date
ES8304934A1 true ES8304934A1 (en) 1983-04-01
ES510286A0 ES510286A0 (en) 1983-04-01

Family

ID=26935366

Family Applications (1)

Application Number Title Priority Date Filing Date
ES510286A Granted ES510286A0 (en) 1981-03-11 1982-03-10 "A PROCEDURE FOR THE PREPARATION OF NEW FLUORINE-PROSTACICLINES".

Country Status (19)

Country Link
AT (1) AT381308B (en)
AU (2) AU558000B2 (en)
CA (1) CA1208634A (en)
CH (2) CH651033A5 (en)
DE (1) DE3208880A1 (en)
DK (1) DK104882A (en)
ES (1) ES510286A0 (en)
FR (3) FR2503161B1 (en)
GB (2) GB2094310B (en)
HU (1) HU190684B (en)
IE (1) IE52388B1 (en)
IL (1) IL65177A (en)
IT (1) IT1195917B (en)
LU (1) LU83992A1 (en)
NL (1) NL8200992A (en)
NO (1) NO154494C (en)
NZ (1) NZ199912A (en)
PH (2) PH17410A (en)
SE (2) SE453294B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
DK40485A (en) * 1984-03-02 1985-09-03 Hoffmann La Roche Prostaglandin intermediates
US4680415A (en) * 1985-06-24 1987-07-14 Hoffmann-La Roche Inc. Intermediates for 7-fluoro dihydro PGI compounds
US4634782A (en) * 1985-06-24 1987-01-06 Hoffmann-La Roche Inc. 7-fluoro-dihydro PGI compounds
CH674363A5 (en) * 1986-12-01 1990-05-31 Hoffmann La Roche
US4808734A (en) * 1986-12-01 1989-02-28 Hoffmann-La Roche Inc. 16-cycloalkyl-7-fluoro-prostacyclins
RU2239925C1 (en) * 2003-09-03 2004-11-10 Анисимова Ирина Александровна Spark plug for internal-combustion engine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs
GB1583961A (en) * 1976-05-11 1981-02-04 Wellcome Found Prostacyclin and derivatives thereof
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
DE2811950A1 (en) * 1978-03-18 1979-12-13 Hoechst Ag NEW PROSTACYCLIN ANALOGS
US4254042A (en) * 1979-07-05 1981-03-03 The Upjohn Company 19-Hydroxy-19-methyl-4,5-didehydro-PGI1 compounds
WO1981001002A1 (en) * 1979-10-10 1981-04-16 Univ Chicago Fluoro-substituted prostaglandins and prostacyclins
GB2084991B (en) * 1980-09-22 1984-06-20 Hoffmann La Roche Prostacyclins
US4565827A (en) * 1980-10-27 1986-01-21 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. 7-Substituted PGI2 -derivatives and pharmaceutical compositions containing them
EP0054795B1 (en) * 1980-12-09 1987-07-15 Teijin Limited Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof

Also Published As

Publication number Publication date
AU6855587A (en) 1987-05-07
ATA94982A (en) 1986-02-15
GB2094310A (en) 1982-09-15
FR2515650A1 (en) 1983-05-06
IL65177A (en) 1985-10-31
AT381308B (en) 1986-09-25
PH18584A (en) 1985-08-12
IT1195917B (en) 1988-11-03
GB2158822B (en) 1986-06-18
CH648556A5 (en) 1985-03-29
FR2503161B1 (en) 1986-04-18
ES510286A0 (en) 1983-04-01
PH17410A (en) 1984-08-08
FR2503161A1 (en) 1982-10-08
GB2158822A (en) 1985-11-20
AU8115682A (en) 1982-09-16
FR2515644A1 (en) 1983-05-06
DK104882A (en) 1982-09-12
NO154494C (en) 1986-10-01
IE820547L (en) 1982-09-11
IE52388B1 (en) 1987-10-14
NO820779L (en) 1982-09-13
LU83992A1 (en) 1983-11-17
FR2515650B1 (en) 1985-08-09
DE3208880A1 (en) 1982-09-23
HU190684B (en) 1986-10-28
AU576441B2 (en) 1988-08-25
NO154494B (en) 1986-06-23
SE8703023L (en) 1987-07-31
CH651033A5 (en) 1985-08-30
SE8201506L (en) 1982-09-12
FR2515644B1 (en) 1984-05-25
GB2094310B (en) 1985-07-03
IL65177A0 (en) 1982-05-31
CA1208634A (en) 1986-07-29
NL8200992A (en) 1982-10-01
GB8426077D0 (en) 1984-11-21
SE453294B (en) 1988-01-25
SE8703023D0 (en) 1987-07-31
IT8219966A0 (en) 1982-03-04
AU558000B2 (en) 1987-01-15
NZ199912A (en) 1985-08-30

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