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ES8304970A1 - A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 1-BENCIL-4 (4- (2-PIRIMIDINILAMINO) BENCIL-2,3-DIOXOPIPERAZINA OR ITS SALTS. - Google Patents

A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 1-BENCIL-4 (4- (2-PIRIMIDINILAMINO) BENCIL-2,3-DIOXOPIPERAZINA OR ITS SALTS.

Info

Publication number
ES8304970A1
ES8304970A1 ES509391A ES509391A ES8304970A1 ES 8304970 A1 ES8304970 A1 ES 8304970A1 ES 509391 A ES509391 A ES 509391A ES 509391 A ES509391 A ES 509391A ES 8304970 A1 ES8304970 A1 ES 8304970A1
Authority
ES
Spain
Prior art keywords
bencil
salts
procedure
pirimidinilamino
dioxopiperazina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509391A
Other languages
Spanish (es)
Other versions
ES509391A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of ES509391A0 publication Critical patent/ES509391A0/en
Publication of ES8304970A1 publication Critical patent/ES8304970A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 1-BENCIL-4- 4-(2-PIRIMIDINILAMINO)BENCIL -2,3-DIOXOPIPERAZINA Y DE SUS SALES, DE FORMULA (I), EN LA QUE R PUEDE SER UNO DE VARIOS RADICALES, R ES HIDROGENO O ALQUILO; Y X ES OXIGENO O AZUFRE. CONSISTE EN LA REACCION DE 1-BENCIL-4- 4-(2-PIPIRIMIDINILAMINO)BENCIL -2,3-DIOXOPIPERAZINA, O UNO DE SUS DERIVADOS REACTIVOS, CON UN COMPUESTO DE FORMULA (II), EN LA QUE Y ES UN GRUPO REACTIVO Y X, R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN PRESENCIA O AUSENCIA DE UN DISOLVENTE INERTE, A UNA TEMPERATURA ENTRE 0 C Y 150 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD CARCINOSTATICA.PROCEDURE FOR OBTAINING DERIVATIVES OF 1-BENZYL-4- 4- (2-PYRIMIDINYLAMINE) BENCIL -2,3-DIOXOPIPERAZINE AND ITS SALTS, OF FORMULA (I), IN WHICH R CAN BE ONE OF SEVERAL RADICALS, R IT IS HYDROGEN OR ALKYL; AND X IS OXYGEN OR SULFUR. IT CONSISTS OF THE REACTION OF 1-BENZYL-4- 4- (2-PIPYRIMIDINYLAMINE) BENCIL -2,3-DIOXOPIPERAZINE, OR ONE OF ITS REACTIVE DERIVATIVES, WITH A COMPOUND OF FORMULA (II), IN WHICH Y IS A REACTIVE GROUP YX, R AND R HAVE THE SAME MEANING AS IN THE FORMULA (I). THE REACTION IS EFFECTED IN THE PRESENCE OR ABSENCE OF AN INERT SOLVENT, AT A TEMPERATURE BETWEEN 0 C AND 150 C. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS DUE TO THEIR CARCINOSTATIC ACTIVITY.

ES509391A 1981-02-06 1982-02-05 A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 1-BENCIL-4 (4- (2-PIRIMIDINILAMINO) BENCIL-2,3-DIOXOPIPERAZINA OR ITS SALTS. Expired ES8304970A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56015837A JPS57140783A (en) 1981-02-06 1981-02-06 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same

Publications (2)

Publication Number Publication Date
ES509391A0 ES509391A0 (en) 1983-03-16
ES8304970A1 true ES8304970A1 (en) 1983-03-16

Family

ID=11899943

Family Applications (2)

Application Number Title Priority Date Filing Date
ES509391A Expired ES8304970A1 (en) 1981-02-06 1982-02-05 A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 1-BENCIL-4 (4- (2-PIRIMIDINILAMINO) BENCIL-2,3-DIOXOPIPERAZINA OR ITS SALTS.
ES518304A Granted ES518304A0 (en) 1981-02-06 1982-12-16 A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 1-BENCIL-4- (4- (2-PIRIMIDINILAMINO) BENCIL) -2,3-DIOXOPIPERAZINE OR ITS SALTS.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES518304A Granted ES518304A0 (en) 1981-02-06 1982-12-16 A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 1-BENCIL-4- (4- (2-PIRIMIDINILAMINO) BENCIL) -2,3-DIOXOPIPERAZINE OR ITS SALTS.

Country Status (12)

Country Link
JP (1) JPS57140783A (en)
KR (1) KR880001105B1 (en)
AU (1) AU537512B2 (en)
BE (1) BE892032A (en)
CH (1) CH651036A5 (en)
DE (1) DE3204074A1 (en)
ES (2) ES8304970A1 (en)
FR (1) FR2499569A1 (en)
GB (1) GB2094296B (en)
IT (1) IT1154274B (en)
NL (1) NL8200451A (en)
SE (1) SE449101B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2275933A1 (en) * 1996-12-24 1998-07-02 Chugai Seiyaku Kabushiki Kaisha Aromatic amine derivatives having nos inhibiting action
EP3778559A4 (en) * 2018-04-11 2021-05-12 Mitsubishi Gas Chemical Company, Inc. Method for preparing dicyanoalkane and bis(aminomethyl)alkane
KR102729448B1 (en) * 2019-03-27 2024-11-14 다이킨 고교 가부시키가이샤 Method for producing halogenated cycloalkane compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5618969A (en) * 1979-07-24 1981-02-23 Toyama Chem Co Ltd Novel 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative, its acid addition salt, and their preparation

Also Published As

Publication number Publication date
IT1154274B (en) 1987-01-21
NL8200451A (en) 1982-09-01
IT8247729A0 (en) 1982-02-05
ES8402285A1 (en) 1984-01-16
FR2499569A1 (en) 1982-08-13
FR2499569B1 (en) 1985-02-22
AU537512B2 (en) 1984-06-28
ES509391A0 (en) 1983-03-16
AU8024082A (en) 1982-08-12
KR880001105B1 (en) 1988-06-29
ES518304A0 (en) 1984-01-16
BE892032A (en) 1982-08-05
SE8200679L (en) 1982-09-22
GB2094296B (en) 1985-02-13
GB2094296A (en) 1982-09-15
IT8247729A1 (en) 1983-08-05
DE3204074A1 (en) 1982-10-28
JPS57140783A (en) 1982-08-31
SE449101B (en) 1987-04-06
JPS6366319B2 (en) 1988-12-20
KR830009090A (en) 1983-12-17
DE3204074C2 (en) 1987-12-23
CH651036A5 (en) 1985-08-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980203