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ES8304201A1 - Un procedimiento para la preparacion de nuevas lactonas macrociclicas. - Google Patents

Un procedimiento para la preparacion de nuevas lactonas macrociclicas.

Info

Publication number
ES8304201A1
ES8304201A1 ES506478A ES506478A ES8304201A1 ES 8304201 A1 ES8304201 A1 ES 8304201A1 ES 506478 A ES506478 A ES 506478A ES 506478 A ES506478 A ES 506478A ES 8304201 A1 ES8304201 A1 ES 8304201A1
Authority
ES
Spain
Prior art keywords
procedure
preparation
macrocyclic lactones
new macrocyclic
lactones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506478A
Other languages
English (en)
Other versions
ES506478A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES506478A0 publication Critical patent/ES506478A0/es
Publication of ES8304201A1 publication Critical patent/ES8304201A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE LACTONAS MACROCICLICAS DE FORMULA (I), EN LA QUE R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN CULTIVAR UNA CEPA PRODUCTORA DE ~ASTREPTOMYCES~B ESP. MA-5038, EN UN MEDIO DE CULTIVO NUTRIENTE ACUOSO, QUE CONTIENE FUENTES DE CARBONO Y DE NITROGENO ASIMILABLES Y SALES INORGANICAS, EN CONDICIONES AEROBIAS, A UN PH ENTRE 5,0 Y 9,0 Y A TEMPERATURAS ENTRE 20 C Y 40 C; Y RECUPERAR EL COMPUESTO OBTENIDO DEL MEDIO DE CULTIVO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO INSECTICIDAS Y TENICIDAS.
ES506478A 1980-10-23 1981-10-22 Un procedimiento para la preparacion de nuevas lactonas macrociclicas. Expired ES8304201A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19990080A 1980-10-23 1980-10-23

Publications (2)

Publication Number Publication Date
ES506478A0 ES506478A0 (es) 1983-02-16
ES8304201A1 true ES8304201A1 (es) 1983-02-16

Family

ID=22739478

Family Applications (1)

Application Number Title Priority Date Filing Date
ES506478A Expired ES8304201A1 (es) 1980-10-23 1981-10-22 Un procedimiento para la preparacion de nuevas lactonas macrociclicas.

Country Status (8)

Country Link
EP (1) EP0050964B1 (es)
JP (1) JPS57102886A (es)
AT (1) ATE25683T1 (es)
DE (1) DE3175950D1 (es)
DK (1) DK466281A (es)
ES (1) ES8304201A1 (es)
GR (1) GR75060B (es)
PT (1) PT73865B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58134992A (ja) * 1982-01-21 1983-08-11 Kitasato Inst:The 抗生物質ａｍ−２６０４−ａおよびその製造方法
US4952604A (en) * 1989-05-03 1990-08-28 Merck & Co., Inc. Antifungal agent

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1587685A (en) * 1977-03-09 1981-04-08 Microbial Chem Res Found Macrolactone derivatives and their production

Also Published As

Publication number Publication date
PT73865A (en) 1981-11-01
EP0050964A2 (en) 1982-05-05
PT73865B (en) 1983-10-25
JPS57102886A (en) 1982-06-26
ES506478A0 (es) 1983-02-16
EP0050964B1 (en) 1987-03-04
DK466281A (da) 1982-04-24
ATE25683T1 (de) 1987-03-15
GR75060B (es) 1984-07-13
DE3175950D1 (en) 1987-04-09
EP0050964A3 (en) 1982-09-08

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