ES8301974A3 - A procedure for the preparation of a 4-fluorofenil-piperidine replaced in position 3 (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of a 4-fluorofenil-piperidine replaced in position 3 (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES8301974A3 ES8301974A3 ES504997A ES504997A ES8301974A3 ES 8301974 A3 ES8301974 A3 ES 8301974A3 ES 504997 A ES504997 A ES 504997A ES 504997 A ES504997 A ES 504997A ES 8301974 A3 ES8301974 A3 ES 8301974A3
- Authority
- ES
- Spain
- Prior art keywords
- translation
- machine
- legally binding
- google translate
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Process for the obtaining of substitute 4-fluorophenil-piperidins in position 3 and of their physiologically compatible acid addition salts, of formula (I), where r is hydrogen or alcohil c <003>; and the atom of fluor can occupy any available position. It consists of the reaction of 3,4-methylendioxypenol with a derivative of formula (II) pyridine, where r is the same as in formula (I), and x is halogen, group ester or hydroxyl. When x is chlorine or ester group, the reaction is carried out in methanol, in the presence of sodium at a temperature between 0ºc and lade reflux. When x is hydroxyl the reaction is carried out through a coupling reagent at a temperature between 160ºc and 180ºc. These compounds have pharmacological applications as antidepressive and anti-perkinsonian agents. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES504997A ES504997A0 (en) | 1981-08-26 | 1981-08-26 | A PROCEDURE FOR THE PREPARATION OF A SUBSTITUTED 4-FLUOROPHENYL-PIPERI-DINE IN POSITION 3 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES504997A ES504997A0 (en) | 1981-08-26 | 1981-08-26 | A PROCEDURE FOR THE PREPARATION OF A SUBSTITUTED 4-FLUOROPHENYL-PIPERI-DINE IN POSITION 3 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8301974A3 true ES8301974A3 (en) | 1983-01-01 |
| ES504997A0 ES504997A0 (en) | 1983-01-01 |
Family
ID=8482885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES504997A Granted ES504997A0 (en) | 1981-08-26 | 1981-08-26 | A PROCEDURE FOR THE PREPARATION OF A SUBSTITUTED 4-FLUOROPHENYL-PIPERI-DINE IN POSITION 3 |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES504997A0 (en) |
-
1981
- 1981-08-26 ES ES504997A patent/ES504997A0/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ES504997A0 (en) | 1983-01-01 |
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