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ES8301890A1 - PROCEDURE FOR THE PREPARATION OF NEW PHENYLALCOHYLAMINS. - Google Patents

PROCEDURE FOR THE PREPARATION OF NEW PHENYLALCOHYLAMINS.

Info

Publication number
ES8301890A1
ES8301890A1 ES507635A ES507635A ES8301890A1 ES 8301890 A1 ES8301890 A1 ES 8301890A1 ES 507635 A ES507635 A ES 507635A ES 507635 A ES507635 A ES 507635A ES 8301890 A1 ES8301890 A1 ES 8301890A1
Authority
ES
Spain
Prior art keywords
formula
procedure
radicals
several types
phenylalcohylamins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507635A
Other languages
Spanish (es)
Other versions
ES507635A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES507635A0 publication Critical patent/ES507635A0/en
Publication of ES8301890A1 publication Critical patent/ES8301890A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
    • G11B23/00—Record carriers not specific to the method of recording or reproducing; Accessories, e.g. containers, specially adapted for co-operation with the recording or reproducing apparatus ; Intermediate mediums; Apparatus or processes specially adapted for their manufacture
    • G11B23/02—Containers; Storing means both adapted to cooperate with the recording or reproducing means
    • G11B23/04—Magazines; Cassettes for webs or filaments
    • G11B23/08—Magazines; Cassettes for webs or filaments for housing webs or filaments having two distinct ends
    • G11B23/087—Magazines; Cassettes for webs or filaments for housing webs or filaments having two distinct ends using two different reels or cores
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
    • G11B25/00—Apparatus characterised by the shape of record carrier employed but not specific to the method of recording or reproducing, e.g. dictating apparatus; Combinations of such apparatus
    • G11B25/06—Apparatus characterised by the shape of record carrier employed but not specific to the method of recording or reproducing, e.g. dictating apparatus; Combinations of such apparatus using web-form record carriers, e.g. tape
    • G11B25/066—Apparatus characterised by the shape of record carrier employed but not specific to the method of recording or reproducing, e.g. dictating apparatus; Combinations of such apparatus using web-form record carriers, e.g. tape adapted for use with containers of different sizes or configurations; adaptor devices therefor

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE FENILALCOHILAMINAS, DE SUS ANTIPODAS OPTICAMENTE ACTIVOS, RACEMATOS DIASTEREOISOMEROS Y DE SUS ANTIPODAS OPTICOS Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE R ES HIDROGENO O ALCOHILO C <003> ; Y A, B, R , R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE REDUCCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE X Y B PUEDEN SER VARIOS TIPOS DE RADICALES, Y R , R , R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO CON UN HIDRURO, ISOPROPILATO DE ALUMINIO O HIDROGENO ACTIVADO, EN UN DISOLVENTE ORGANICO O ACUORGANICO, A UNA TEMPERATURA ENTRE -20<025>C Y LA DE EBULLICION DE LA MEZCLA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS SOBRE LA PRESION SANGUINEA, ANTIARRITMICO Y/O CARDIOTONICO.PROCEDURE FOR OBTAINING PHENYLALCOHYLAMINES, OF THEIR OPTICALLY ACTIVE ANTIPODES, DIASTEREOISOMER RACEMATES AND OF THEIR OPTICAL ANTIPODES AND OF THEIR ACID ADDITION SALTS, OF FORMULA (I), IN WHICH R IS HYDROGEN OR <003> C003> ALCOHOL; AND A, B, R, R, R AND R CAN BE SEVERAL TYPES OF RADICALS. CONSISTS OF THE REDUCTION REACTION OF A COMPOUND OF FORMULA (II), IN WHICH X AND B CAN BE SEVERAL TYPES OF RADICALS, AND R, R, R AND R HAVE THE SAME MEANING AS IN FORMULA (I). THE REACTION IS CARRIED OUT WITH A HYDRIDE, ALUMINUM ISOPROPYLATE OR ACTIVATED HYDROGEN, IN AN ORGANIC OR AQUORGANIC SOLVENT, AT A TEMPERATURE BETWEEN -20 <025> C AND THE BOILING TEMPERATURE OF THE MIXTURE. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS FOR THEIR EFFECTS ON BLOOD PRESSURE, ANTIARRHYTHMIC AND / OR CARDIOTONIC.

ES507635A 1980-12-10 1981-12-02 PROCEDURE FOR THE PREPARATION OF NEW PHENYLALCOHYLAMINS. Expired ES8301890A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3046465 1980-12-10

Publications (2)

Publication Number Publication Date
ES507635A0 ES507635A0 (en) 1983-01-01
ES8301890A1 true ES8301890A1 (en) 1983-01-01

Family

ID=6118763

Family Applications (4)

Application Number Title Priority Date Filing Date
ES507635A Expired ES8301890A1 (en) 1980-12-10 1981-12-02 PROCEDURE FOR THE PREPARATION OF NEW PHENYLALCOHYLAMINS.
ES512913A Expired ES8304536A1 (en) 1980-12-10 1982-06-08 Chemical Compounds
ES512915A Granted ES512915A0 (en) 1980-12-10 1982-06-08 "PROCEDURE FOR THE PREPARATION OF NEW PHENYLALCOHYLAMINS".
ES512914A Expired ES8304537A1 (en) 1980-12-10 1982-06-08 "PROCEDURE FOR THE PREPARATION OF NEW PHENYLALCOHYLAMINS".

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES512913A Expired ES8304536A1 (en) 1980-12-10 1982-06-08 Chemical Compounds
ES512915A Granted ES512915A0 (en) 1980-12-10 1982-06-08 "PROCEDURE FOR THE PREPARATION OF NEW PHENYLALCOHYLAMINS".
ES512914A Expired ES8304537A1 (en) 1980-12-10 1982-06-08 "PROCEDURE FOR THE PREPARATION OF NEW PHENYLALCOHYLAMINS".

Country Status (32)

Country Link
JP (1) JPS57122048A (en)
KR (1) KR870000183B1 (en)
AR (1) AR227802A1 (en)
AT (1) AT379378B (en)
AU (1) AU547655B2 (en)
BE (1) BE891416A (en)
CA (1) CA1202636A (en)
CH (1) CH651541A5 (en)
CS (1) CS229924B2 (en)
DD (1) DD202867A5 (en)
DE (1) DE3146623A1 (en)
DK (1) DK541981A (en)
ES (4) ES8301890A1 (en)
FI (1) FI813934L (en)
FR (1) FR2498596B1 (en)
GB (1) GB2088873B (en)
GR (1) GR77323B (en)
HU (1) HU185676B (en)
IE (1) IE52007B1 (en)
IL (1) IL64498A (en)
IT (1) IT1172129B (en)
LU (1) LU83830A1 (en)
NL (1) NL8105170A (en)
NO (1) NO152649C (en)
NZ (1) NZ199215A (en)
PH (1) PH21599A (en)
PL (1) PL129385B1 (en)
PT (1) PT74112B (en)
SE (1) SE8107387L (en)
SU (1) SU1172449A3 (en)
YU (1) YU290381A (en)
ZA (1) ZA818529B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4720586A (en) * 1983-12-06 1988-01-19 Fisons, Plc Substituted 3,4-dihydroxy-phenylethylamino compounds
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
US4943591A (en) * 1984-10-17 1990-07-24 Glaxo Group Limited Dichloroaniline derivatives
GB8426191D0 (en) * 1984-10-17 1984-11-21 Glaxo Holdings Ltd Chemical compounds
GB8603475D0 (en) * 1986-02-12 1986-03-19 Glaxo Group Ltd Chemical compounds
GB8703007D0 (en) * 1987-02-10 1987-03-18 Glaxo Group Ltd Chemical compounds
EP0278727A3 (en) * 1987-02-10 1990-03-14 Glaxo Group Limited 1-(4-amino-3-chloro-5-trifluoromethylphenyl)-2-(substituted amino)ethanol derivatives and their use in the treatment of respiratory disease
US4906645A (en) * 1988-09-12 1990-03-06 Merck & Co., Inc. Pyridyl aminoethanol compounds with growth promotion and an increase in feed efficiency
DE4028398A1 (en) * 1990-09-07 1992-03-12 Thomae Gmbh Dr K PHENYLETHANOLAMINES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
US5495046A (en) * 1991-01-04 1996-02-27 Taisho Pharmaceutical Co., Ltd. Alkoxyphenylalkylamine derivatives
US8349898B2 (en) * 2008-11-18 2013-01-08 Wisconsin Alumni Research Foundation Sigma-1 receptor ligands and methods of use
GB201208775D0 (en) 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds
US11999676B2 (en) 2016-04-21 2024-06-04 University Of Kentucky Research Foundation Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse
US10668030B2 (en) * 2016-04-21 2020-06-02 University Of Kentucky Research Foundation Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse
JP2025518760A (en) * 2022-05-31 2025-06-19 コルテバ アグリサイエンス エルエルシー Crystalline forms of picolinamide fungicide compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1618007A1 (en) * 1967-05-09 1970-10-29 Thomae Gmbh Dr K Process for the production of new amino-monohalophenylaethanolamines
DE2351281C3 (en) * 1973-10-12 1981-07-30 Dr. Karl Thomae Gmbh, 7950 Biberach Aminophenylethanolamine derivatives, their production and use
NL176168C (en) * 1972-12-18 1985-03-01 Thomae Gmbh Dr K PROCEDURE FOR THE PREPARATION OR MANUFACTURE OF A PHARMACEUTICAL PREPARATION AND METHOD FOR THE PREPARATION OF USEFUL NEW SUBSTITUTED 1-(4-AMINOPHENYL)-2-AMINO-ETHANOL DERIVATIVES WHICH, EXCEPT AN ANALGETIC, UTERUS SPASMOLYTIC AND ANTI-SPASTIC ACTIVITY, HAVE RELATIVE STRIPES IN PARTICULAR HAVE A BETA2 MIMETIC AND/OR BETA1 BLOCKING ACTIVITY.
GB1523974A (en) * 1975-02-05 1978-09-06 Yamanouchi Pharma Co Ltd 4-substituted amino- -aminomethylbenzyl alcohol derivatives
JPS51125232A (en) * 1975-02-05 1976-11-01 Yamanouchi Pharmaceut Co Ltd Process for preparing 4-substituted amido-3,5-dihalogeno-alpha-substituted aminomethylbenzyl alcohols
DK58679A (en) * 1978-02-21 1979-08-22 Sandoz Ag PROCEDURE FOR THE PREPARATION OF PHENYLETHYLAMINES
CA1120058A (en) * 1978-07-03 1982-03-16 Jack Mills Phenethanolamines, formulations and potentiation of oncolytic drugs

Also Published As

Publication number Publication date
PL129385B1 (en) 1984-05-31
FR2498596A1 (en) 1982-07-30
PT74112B (en) 1984-10-09
IE812888L (en) 1982-06-10
ES512913A0 (en) 1983-03-01
ZA818529B (en) 1983-08-31
ATA512981A (en) 1985-05-15
IT1172129B (en) 1987-06-18
ES512914A0 (en) 1983-03-01
AU7841481A (en) 1982-09-23
BE891416A (en) 1982-06-09
FI813934A7 (en) 1982-06-11
KR830007505A (en) 1983-10-21
ES507635A0 (en) 1983-01-01
DE3146623A1 (en) 1982-07-15
KR870000183B1 (en) 1987-02-14
NO814194L (en) 1982-06-11
GR77323B (en) 1984-09-11
IL64498A0 (en) 1982-03-31
SU1172449A3 (en) 1985-08-07
FR2498596B1 (en) 1986-03-21
LU83830A1 (en) 1983-04-13
CS229924B2 (en) 1984-07-16
CH651541A5 (en) 1985-09-30
ES8304536A1 (en) 1983-03-01
DD202867A5 (en) 1983-10-05
DK541981A (en) 1982-06-11
FI813934L (en) 1982-06-11
GB2088873B (en) 1984-10-17
NZ199215A (en) 1986-07-11
YU290381A (en) 1983-10-31
PT74112A (en) 1982-01-01
PL234155A1 (en) 1982-08-02
ES8304538A1 (en) 1983-03-01
HU185676B (en) 1985-03-28
IE52007B1 (en) 1987-05-13
PH21599A (en) 1987-12-11
NL8105170A (en) 1982-07-01
ES8304537A1 (en) 1983-03-01
IL64498A (en) 1985-08-30
CA1202636A (en) 1986-04-01
GB2088873A (en) 1982-06-16
AR227802A1 (en) 1982-12-15
AU547655B2 (en) 1985-10-31
JPS57122048A (en) 1982-07-29
IT8149853A0 (en) 1981-12-07
SE8107387L (en) 1982-07-26
NO152649B (en) 1985-07-22
NO152649C (en) 1985-10-30
AT379378B (en) 1985-12-27
ES512915A0 (en) 1983-03-01

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