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ES8301463A1 - PROCEDURE FOR THE PRODUCTION OF A POLYPEPTIDE - Google Patents

PROCEDURE FOR THE PRODUCTION OF A POLYPEPTIDE

Info

Publication number
ES8301463A1
ES8301463A1 ES497113A ES497113A ES8301463A1 ES 8301463 A1 ES8301463 A1 ES 8301463A1 ES 497113 A ES497113 A ES 497113A ES 497113 A ES497113 A ES 497113A ES 8301463 A1 ES8301463 A1 ES 8301463A1
Authority
ES
Spain
Prior art keywords
polypeptide
hydrogen
group
formula
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497113A
Other languages
Spanish (es)
Other versions
ES497113A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8301463A1 publication Critical patent/ES8301463A1/en
Publication of ES497113A0 publication Critical patent/ES497113A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PRODUCCION DE UN POLIPEPTIDO, DE FORMULA GENERAL (I), EN DONDE A ES ALQUILO C <003> O FENILALQUILO C <003> ; A'' ES HIDROGENO; B ES -PHE-; C ES -(L)- O -(D) RP-; D ES -LYS E ES EL RESIDUO DE UN <007>-AMINOACIDO NATURAL; F ES UN GRUPO DE FORMULA: <024>COOR O <024>C OR ; DONDE R ES HIDROGENO O ALQUILO, Y R ES UN ESTER FISIOLOGICAMENTE HIDROLIZABLE; Y E Y SON HIDROGENO O JUNTOS REPRESENTAN UN ENLACE DIRECTO. CONSISTE EN SEPARAR AL MENOS UN GRUPO PROTECTOR DE UN POLIPEPTIDO EN FORMA PROTEGIDA Y QUE TENGA LA SECUENCIA DE LA FORMULA (I), TAL COMO UN GRUPO TERC-BUTILOXICARBONILO O P-METOXIBENCILO PROTECTOR, POR TRATAMIENTO CON TRIS-TRIFLUORACETATO DE BORO, EN PRESENCIA DE TIOANISOL Y UN DISOLVENTE ORGANICO INERTE. DE USO COMO AGENTES FARMACEUTICAMENTE ACTIVOS.PROCEDURE FOR THE PRODUCTION OF A POLYPEPTIDE, OF GENERAL FORMULA (I), IN WHICH A IS ALKYL C <003> OR PHENYLALKYL C <003>; A'' IS HYDROGEN; B IS -PHE-; C IS -(L)- OR -(D)RP-; D IS -LYS E IS THE RESIDUE OF A NATURAL <007>-AMINO ACID; F IS A GROUP OF FORMULA: <024>COOR OR <024>C OR ; WHERE R IS HYDROGEN OR ALKYL, AND R IS A PHYSIOLOGICALLY HYDROLYZABLE ESTER; AND AND Y ARE HYDROGEN OR TOGETHER THEY REPRESENT A DIRECT BOND. CONSISTS IN SEPARATING AT LEAST ONE PROTECTIVE GROUP OF A POLYPEPTIDE IN A PROTECTED FORM AND HAVING THE SEQUENCE OF FORMULA (I), SUCH AS A PROTECTIVE TERC-BUTYLOXICARBONYL OR P-METHOXYBENCYL GROUP, BY TREATMENT WITH BORON TRIS-TRIFLUORACETATE, IN THE PRESENCE OF TIOANISOL AND AN INERT ORGANIC SOLVENT. FOR USE AS PHARMACEUTICALLY ACTIVE AGENTS.

ES497113A 1979-11-27 1980-11-25 PROCEDURE FOR THE PRODUCTION OF A POLYPEPTIDE Granted ES497113A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1052479 1979-11-27
CH457480 1980-06-13

Publications (2)

Publication Number Publication Date
ES8301463A1 true ES8301463A1 (en) 1982-12-01
ES497113A0 ES497113A0 (en) 1982-12-01

Family

ID=25695798

Family Applications (2)

Application Number Title Priority Date Filing Date
ES497113A Granted ES497113A0 (en) 1979-11-27 1980-11-25 PROCEDURE FOR THE PRODUCTION OF A POLYPEPTIDE
ES510751A Granted ES510751A0 (en) 1979-11-27 1982-03-24 PROCEDURE FOR THE PRODUCTION OF A POLYPEPTIDE.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES510751A Granted ES510751A0 (en) 1979-11-27 1982-03-24 PROCEDURE FOR THE PRODUCTION OF A POLYPEPTIDE.

Country Status (25)

Country Link
US (1) US4395403A (en)
EP (1) EP0029579B1 (en)
JP (1) JPS5690048A (en)
AT (1) ATE2512T1 (en)
AU (1) AU543198B2 (en)
CA (1) CA1182109A (en)
CS (1) CS228140B2 (en)
CY (1) CY1327A (en)
DE (2) DE19375086I2 (en)
DK (1) DK150146C (en)
ES (2) ES497113A0 (en)
FI (1) FI72981C (en)
GR (1) GR71636B (en)
HK (1) HK30686A (en)
HU (1) HU185920B (en)
IE (1) IE50571B1 (en)
IL (1) IL61561A (en)
KE (1) KE3606A (en)
LU (1) LU88344I2 (en)
MY (1) MY8500072A (en)
NL (1) NL930137I2 (en)
NZ (1) NZ195640A (en)
PH (1) PH22841A (en)
PT (1) PT72103B (en)
SG (1) SG8786G (en)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK81082A (en) * 1981-03-06 1982-09-07 Sandoz Ag PROCEDURE FOR PREPARING POLYPEPTIDES
CH655505B (en) * 1982-08-24 1986-04-30
US4663435A (en) * 1982-12-06 1987-05-05 Merck & Co., Inc. Bridged cyclic hexapeptide somatostatin analogs
FR2554347B1 (en) * 1983-11-07 1986-10-03 Immunotech Sa PRESSINIC ACID, ITS SUBSTITUTED AMINOACID DERIVATIVES AND HOMOLOGATED CONFIGURATION AS WELL AS THE N- AND C- TERMINAL-SUBSTITUTED DERIVATIVES AND THEIR APPLICATIONS IN THE THERAPEUTIC, BIOLOGICAL OR IMMUNOLOGICAL FIELDS
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
GB8423431D0 (en) * 1984-09-17 1984-10-24 Sandoz Ltd Organic compounds
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
JPH085913B2 (en) * 1985-09-12 1996-01-24 ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド Therapeutic somatostatin congeners
GR862206B (en) * 1985-09-12 1986-12-31 Univ Tulane Therapeutic somatostatin analogs
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
HU198626B (en) * 1986-05-27 1989-11-28 Sandoz Ag Process for producing pharmaceutical compositions comprising somatostatin analogues as active ingredient
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
GB2193891B (en) * 1986-08-18 1990-07-25 Sandoz Ltd Nasal pharmaceutical composition containing a somatostatin anologue.
DE3726517A1 (en) * 1986-08-18 1988-03-03 Sandoz Ag NASAL COMPOSITIONS CONTAINING OCTREOTIDE
GB8620035D0 (en) * 1986-08-18 1986-10-01 Sandoz Ltd Organic compounds
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
DE3790635B4 (en) * 1986-10-13 2007-11-22 Novartis Ag New sugar derivs. of biologically active peptide(s) - have prolonged duration of action, and are coupled by other than direct N-glycoside bond or direct amide bond
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
ZA895838B (en) * 1988-08-18 1991-03-27 Syntex Inc Pharmaceutical compounds
US5006510A (en) * 1989-06-20 1991-04-09 Ellis Wladislaw V Method for relieving chronic pain with a somatostatin analog composition
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
US5084443A (en) * 1989-12-04 1992-01-28 Biomeasure, Inc. Promoting expression of acetylcholine receptors with lhrh antagonist
ATE140237T1 (en) * 1989-12-08 1996-07-15 Univ Tulane OCTAPEPTIDE ANALOGUES OF SOMATOSTATIN WITH THREONINE IN POSITION 6
DE69229436T2 (en) * 1991-02-08 1999-11-25 Biomeasure, Inc. USE OF SOMATOSTATIN ANALOGS FOR TREATING MELANOMAS
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
GB9402767D0 (en) * 1994-02-14 1994-04-06 Sandoz Ltd Improvements in or relating to organic compounds
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
EP0824103A1 (en) * 1996-08-13 1998-02-18 Chang-Shinn Su Method for synthesis of Tyr-3-octreotide
US6262229B1 (en) 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
CA2289499C (en) * 1997-05-13 2010-02-23 Michael Anthony Cawthorne Somatostatin and somatostatin agonists for treating insulin insensitivity and syndrome x
EP0981364B1 (en) * 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Method and compositions for treating hyperlipidemia
ES2202864T3 (en) 1997-05-13 2004-04-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. AGOMISTS OF THE SOMATOSTATINE TO DECREASE BODY WEIGHT.
ES2144357B1 (en) * 1998-01-29 2000-12-16 Lipotec Sa PROCEDURE FOR OBTAINING THE SOMATOSTATINA OCTREOTIDE ANALOG.
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US6159935A (en) 1999-11-29 2000-12-12 Pharmacia & Upjohn Co. Method for preventing diarrhea
RU2196144C1 (en) * 2001-05-14 2003-01-10 Самуков Владимир Васильевич Protected derivatives of octreotide
ATE424414T1 (en) 2001-06-08 2009-03-15 Sod Conseils Rech Applic CHIMERS SOMATOSTATIN-DOPAMINE ANALOGUE
EP1490090A4 (en) 2002-02-22 2006-09-20 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US6987167B2 (en) 2002-05-22 2006-01-17 Wockhardt Limited Process for production of the somatostatin analog, octreotide
US20040097419A1 (en) 2002-11-19 2004-05-20 Holger Petersen Organic compounds
PT1511761E (en) * 2003-04-07 2006-11-30 Novetide Ltd Process for production of cyclic peptides
EP1624884A4 (en) 2003-04-22 2009-08-05 Ipsen Pharma Somatostatin vectors
EP1709065B1 (en) * 2004-10-04 2010-06-02 Novetide Ltd. A counterion exchange process for peptides
KR101458728B1 (en) 2005-12-22 2014-11-05 노파르티스 아게 Sustained release formulation comprising octreotide and two or more polylactide-co-glycolide polymers
WO2007110765A2 (en) * 2006-03-28 2007-10-04 Wockhardt Ltd Processes for the preparation of octreotide
TW200819137A (en) * 2006-10-31 2008-05-01 Iner Aec Executive Yuan Method for preparation of lipid-spacer radical- reactions of functional group-peptide
US20090082259A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched octreotide
EP2172189A1 (en) 2008-10-01 2010-04-07 Novartis AG Pharmaceutical Compositions
EP2213307A1 (en) 2009-02-03 2010-08-04 Novartis AG Injectable depot formulations
US8377891B2 (en) 2008-11-07 2013-02-19 Usv, Ltd. Process for synthesis of cyclic octapeptide
EP2395987A1 (en) 2009-02-12 2011-12-21 Coöperatieve Mirzorg U.A., Arnhem Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders
US20140296144A1 (en) 2011-09-30 2014-10-02 Mylan Laboratories, Ltd. Process for the preparation of octreotide acetate
CN103102390B (en) * 2011-11-09 2015-01-28 杭州华津允上医药有限公司 Preparation method for octreotide
WO2013132505A1 (en) 2012-03-09 2013-09-12 Natco Pharma Limited Improved process for preparation of octreotide by solution phase peptide synthesis
JP6869720B2 (en) 2013-06-13 2021-05-12 アンチセンス セラピューティクス リミテッド Combination therapy
CN108395469A (en) * 2018-02-01 2018-08-14 滨海吉尔多肽有限公司 A kind of synthetic method of pseudo proline dipeptides
GB202012334D0 (en) 2020-08-07 2020-09-23 Avon Polymer Prod Ltd Monitoring system

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105603A (en) * 1977-03-28 1978-08-08 The Salk Institute For Biological Studies Peptides which effect release of hormones
US4139526A (en) * 1977-12-01 1979-02-13 Merck & Co., Inc. Somatostatin analogs
US4140767A (en) * 1977-12-01 1979-02-20 Merck & Co., Inc. Somatostatin analogs
US4190648A (en) * 1979-03-13 1980-02-26 Merck & Co., Inc. Peptides having somatostatin activity
US4225472A (en) * 1979-05-29 1980-09-30 American Home Products Corporation Truncated somatostatin analogs
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4282143A (en) * 1980-06-13 1981-08-04 American Home Products Corporation Octapeptides lowering growth hormone

Also Published As

Publication number Publication date
FI803634L (en) 1981-05-28
EP0029579B1 (en) 1983-02-16
FI72981B (en) 1987-04-30
IE802452L (en) 1981-05-27
US4395403A (en) 1983-07-26
ATE2512T1 (en) 1983-03-15
GR71636B (en) 1983-06-20
DE3062075D1 (en) 1983-03-24
HU185920B (en) 1985-04-28
PH22841A (en) 1989-01-19
NL930137I2 (en) 1997-02-03
ES8305701A1 (en) 1983-04-16
IE50571B1 (en) 1986-05-14
CS228140B2 (en) 1984-05-14
HK30686A (en) 1986-05-09
ES510751A0 (en) 1983-04-16
MY8500072A (en) 1985-12-31
SG8786G (en) 1987-03-27
KE3606A (en) 1986-03-17
DE19375086I2 (en) 2003-01-09
AU543198B2 (en) 1985-04-04
DK150146B (en) 1986-12-15
IL61561A0 (en) 1980-12-31
PT72103A (en) 1980-12-01
IL61561A (en) 1985-02-28
LU88344I2 (en) 1994-05-04
DK501980A (en) 1981-05-28
JPS6351159B2 (en) 1988-10-13
AU6468880A (en) 1981-06-04
CA1182109A (en) 1985-02-05
PT72103B (en) 1982-01-28
ES497113A0 (en) 1982-12-01
FI72981C (en) 1987-08-10
NL930137I1 (en) 1993-11-01
JPS5690048A (en) 1981-07-21
CY1327A (en) 1986-06-27
NZ195640A (en) 1984-07-06
EP0029579A1 (en) 1981-06-03
DK150146C (en) 1987-06-01

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Legal Events

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