ES8300757A1 - Un procedimiento para la produccion de nuevas isoxolil-indolaminas. - Google Patents
Un procedimiento para la produccion de nuevas isoxolil-indolaminas.Info
- Publication number
- ES8300757A1 ES8300757A1 ES501220A ES501220A ES8300757A1 ES 8300757 A1 ES8300757 A1 ES 8300757A1 ES 501220 A ES501220 A ES 501220A ES 501220 A ES501220 A ES 501220A ES 8300757 A1 ES8300757 A1 ES 8300757A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- hydrogen
- indolamines
- isoxazolyl
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ISOXAZOLIL-INDOLAMINAS DE FORMULA (I), EN LA QUE R , R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES; R ES HIDROGENO O HIDROXILO; Y R ES HIDROGENO O ALQUILO C <003> . CONSISTE EN LA REACCION DE REDUCCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE Z ES <024>CO<024> O <024>CH <024>, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO CON HIDRUROS METALICOS, EN UNA ATMOSFERA INERTE, EN UN DISOLVENTE INERTE, TAL COMO UN ETER A UNA TEMPERATURA ENTRE -10<025>C Y 50<025>C. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIDIABETICOS.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13887280A | 1980-04-10 | 1980-04-10 | |
| US13887380A | 1980-04-10 | 1980-04-10 | |
| US19678580A | 1980-10-14 | 1980-10-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES501220A0 ES501220A0 (es) | 1982-11-01 |
| ES8300757A1 true ES8300757A1 (es) | 1982-11-01 |
Family
ID=27385244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES501220A Expired ES8300757A1 (es) | 1980-04-10 | 1981-04-09 | Un procedimiento para la produccion de nuevas isoxolil-indolaminas. |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP0038298B1 (es) |
| AU (1) | AU546620B2 (es) |
| CA (1) | CA1163267A (es) |
| DE (1) | DE3164982D1 (es) |
| DK (1) | DK153881A (es) |
| ES (1) | ES8300757A1 (es) |
| FI (1) | FI69843C (es) |
| IL (1) | IL62605A (es) |
| MY (1) | MY8500913A (es) |
| NZ (1) | NZ196762A (es) |
| PT (1) | PT72817B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3262353D1 (en) * | 1981-12-14 | 1985-03-28 | Sandoz Ag | N,n-disubstituted alkenamides and phenylalkenamides, processes for their production and their use as pharmaceuticals |
| CH656124A5 (de) * | 1982-04-13 | 1986-06-13 | Sandoz Ag | 2-substituierte-3-indolamine, verfahren zu deren herstellung sowie deren verwendung. |
| NZ227841A (en) * | 1988-02-12 | 1991-08-27 | Merck Sharp & Dohme | Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions |
| GB8808433D0 (en) * | 1988-04-11 | 1988-05-11 | Merck Sharp & Dohme | Therapeutic agents |
| UA37178C2 (uk) * | 1990-06-07 | 2001-05-15 | Астразенека Аб | Терапевтичні гетероциклічні сполуки, спосіб їх одержання, спосіб профілактики та лікування, лікарський засіб та спосіб його одержання |
| ATE384717T1 (de) * | 1997-09-05 | 2008-02-15 | Lead Chem Co Ltd | Stereoisomere indolderivate, verfahren zu ihrer herstellung und ihre verwendung |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1075156A (en) * | 1963-08-27 | 1967-07-12 | Luso Farmaco Inst | Substituted piperazines |
| US3467670A (en) * | 1964-10-05 | 1969-09-16 | Mcneilab Inc | 2-phenyl-3-amido-5,6-dimethoxyindoles |
| US4059583A (en) * | 1975-11-13 | 1977-11-22 | Mcneil Laboratories, Incorporated | Substituted indoles |
-
1981
- 1981-04-01 DE DE8181810131T patent/DE3164982D1/de not_active Expired
- 1981-04-01 EP EP81810131A patent/EP0038298B1/en not_active Expired
- 1981-04-01 EP EP83101610A patent/EP0083566A1/en not_active Withdrawn
- 1981-04-03 DK DK153881A patent/DK153881A/da not_active IP Right Cessation
- 1981-04-08 PT PT72817A patent/PT72817B/pt unknown
- 1981-04-08 CA CA000374979A patent/CA1163267A/en not_active Expired
- 1981-04-08 AU AU69301/81A patent/AU546620B2/en not_active Ceased
- 1981-04-08 NZ NZ196762A patent/NZ196762A/en unknown
- 1981-04-08 IL IL62605A patent/IL62605A/xx unknown
- 1981-04-09 FI FI811101A patent/FI69843C/fi not_active IP Right Cessation
- 1981-04-09 ES ES501220A patent/ES8300757A1/es not_active Expired
-
1985
- 1985-12-30 MY MY913/85A patent/MY8500913A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3164982D1 (de) | 1984-08-30 |
| AU546620B2 (en) | 1985-09-12 |
| ES501220A0 (es) | 1982-11-01 |
| CA1163267A (en) | 1984-03-06 |
| EP0083566A1 (en) | 1983-07-13 |
| FI811101L (fi) | 1981-10-11 |
| PT72817A (en) | 1981-05-01 |
| FI69843B (fi) | 1985-12-31 |
| DK153881A (da) | 1981-10-11 |
| MY8500913A (en) | 1985-12-31 |
| EP0038298B1 (en) | 1984-07-25 |
| IL62605A (en) | 1984-10-31 |
| FI69843C (fi) | 1986-05-26 |
| IL62605A0 (en) | 1981-06-29 |
| NZ196762A (en) | 1984-07-06 |
| AU6930181A (en) | 1981-10-15 |
| PT72817B (en) | 1982-07-26 |
| EP0038298A1 (en) | 1981-10-21 |
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