ES8206973A1 - Procedimiento de preparar soluciones desagregadas de poli- peptidos - Google Patents
Procedimiento de preparar soluciones desagregadas de poli- peptidosInfo
- Publication number
- ES8206973A1 ES8206973A1 ES500634A ES500634A ES8206973A1 ES 8206973 A1 ES8206973 A1 ES 8206973A1 ES 500634 A ES500634 A ES 500634A ES 500634 A ES500634 A ES 500634A ES 8206973 A1 ES8206973 A1 ES 8206973A1
- Authority
- ES
- Spain
- Prior art keywords
- disaggregated
- polypeptides
- solutions
- solution
- glucagon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 102000051325 Glucagon Human genes 0.000 abstract 2
- 108060003199 Glucagon Proteins 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 2
- 229960004666 glucagon Drugs 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PREPARACION DE UNA SOLUCION ACUOSA DE PH 6,8 A 8,0 QUE CONTIENE UN POLIPEPTIDO, TAL COMO INSULINA O GLUCAGON EN FORMA DESAGREGADA Y QUE CONTIENE EL ION DE BICARBONATO. SE INTRODUCE ION BICARBONATO EN AGUA HASTA OBTENER UNA CONCENTRACION DE 2 MOLAR A 2,5 MOLAR Y UN PH 6,8 A 8,0 Y ENTONCES SE PROCEDE A LA DISOLUCION DEL POLIPEPTIDO EN LA DISOLUCION ANTES RESULTANTE. EL ION BICARBONATO SE INTRODUCE EN LA DISOLUCION AÑADIENDO A LA MISMA LOS COMPONENTES DE SUERO DE MAMIFERO, QUE TIENEN UN PESO MOLECULAR INFERIOR A 500 Y OBTENIDO, EXTRAYENDO LA FRACCION DE SANGRE DE MAMIFERO, FILTRANDO EL SUERO PARA ELIMINAR LAS SUSTANCIAS QUE TIENEN UN PESO MOLECULAR INFERIOR A 500, HACIENDO PASAR LAS SUSTANCIAS A TRAVES DE UN GEL CARGADO POSITIVAMENTE A PH 7,0-7,5 PARA ENLAZAR LAS SUSTANCIAS QUE CONTIENEN EL ION BICARBONATO EL GEL, LAVANDO EL GEL A PH 2-4 Y RECOGIENDO EL EXTRACTO RESULTANTE.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA346684 | 1980-02-29 | ||
| US14744480A | 1980-05-07 | 1980-05-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES500634A0 ES500634A0 (es) | 1982-09-16 |
| ES8206973A1 true ES8206973A1 (es) | 1982-09-16 |
Family
ID=25669049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES500634A Expired ES8206973A1 (es) | 1980-02-29 | 1981-02-28 | Procedimiento de preparar soluciones desagregadas de poli- peptidos |
Country Status (5)
| Country | Link |
|---|---|
| DE (1) | DE3107168A1 (es) |
| DK (1) | DK80781A (es) |
| ES (1) | ES8206973A1 (es) |
| GB (1) | GB2070620B (es) |
| NL (1) | NL8100916A (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI78616C (fi) * | 1982-02-05 | 1989-09-11 | Novo Industri As | Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt. |
| ES520249A0 (es) * | 1982-03-03 | 1984-04-16 | Nordisk Insulinlab | Procedimiento de producir preparaciones de insulina. |
-
1981
- 1981-02-24 DK DK80781A patent/DK80781A/da not_active Application Discontinuation
- 1981-02-25 NL NL8100916A patent/NL8100916A/nl not_active Application Discontinuation
- 1981-02-26 DE DE19813107168 patent/DE3107168A1/de not_active Withdrawn
- 1981-02-26 GB GB8106056A patent/GB2070620B/en not_active Expired
- 1981-02-28 ES ES500634A patent/ES8206973A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2070620A (en) | 1981-09-09 |
| ES500634A0 (es) | 1982-09-16 |
| DK80781A (da) | 1981-08-30 |
| NL8100916A (nl) | 1981-10-01 |
| GB2070620B (en) | 1983-11-30 |
| DE3107168A1 (de) | 1981-12-24 |
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