ES8203334A1 - Procedimiento para la obtencion de dehidropeptidos - Google Patents
Procedimiento para la obtencion de dehidropeptidosInfo
- Publication number
- ES8203334A1 ES8203334A1 ES488301A ES488301A ES8203334A1 ES 8203334 A1 ES8203334 A1 ES 8203334A1 ES 488301 A ES488301 A ES 488301A ES 488301 A ES488301 A ES 488301A ES 8203334 A1 ES8203334 A1 ES 8203334A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- compositions containing
- phenylalanyl
- pharmaceutical compositions
- tryptophan derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JMCOUWKXLXDERB-WMZOPIPTSA-N Phe-Trp Chemical class C([C@H](N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)C1=CC=CC=C1 JMCOUWKXLXDERB-WMZOPIPTSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000409 histolytic effect Effects 0.000 abstract 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Flanged Joints, Insulating Joints, And Other Joints (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Liquid Crystal Substances (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DEHIDROPEPTIDOS. CONSISTE EN HACER REACCIONAR OXAZOLES DE FORMULA GENERAL (I) CON DERIVADOS DE TRIPTOFANO (II) EN PRESENCIA DE DISOLVENTES ORGANICOS, AGUA O MEZCLAS DE AMBOS, A TEMPERATURAS COMPRENDIDAS ENTRE 0 Y 80C. SE OBTIENE EL COMPUESTO (III), EN QUE R1 ES HIDROGENO, ALQUILO U OTROS; R2 ES UN RESTO FENILO; R3 Y R4 SON HIDROGENO; R5 ES HIDROXI O ALCOXI; N VALE 1 O 0; C* ES CENTRO DE ASIMETRIA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792904512 DE2904512A1 (de) | 1979-02-07 | 1979-02-07 | Dehydropeptide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES488301A0 ES488301A0 (es) | 1980-08-01 |
| ES8203334A1 true ES8203334A1 (es) | 1980-08-01 |
Family
ID=6062317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES488301A Expired ES8203334A1 (es) | 1979-02-07 | 1980-02-06 | Procedimiento para la obtencion de dehidropeptidos |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4285935A (es) |
| EP (1) | EP0017705B1 (es) |
| JP (1) | JPS55105654A (es) |
| AT (1) | ATE1352T1 (es) |
| CA (1) | CA1147725A (es) |
| DE (2) | DE2904512A1 (es) |
| DK (1) | DK52080A (es) |
| ES (1) | ES8203334A1 (es) |
| FI (1) | FI800350A7 (es) |
| GR (1) | GR73033B (es) |
| HU (1) | HU181052B (es) |
| IL (1) | IL59295A (es) |
| NO (1) | NO149103B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4350628A (en) * | 1979-10-01 | 1982-09-21 | Research Corporation | Preparation of dehydropeptides |
| US4610816A (en) * | 1980-12-18 | 1986-09-09 | Schering Corporation | Substituted dipeptides as inhibitors of enkephalinases |
| US4906615A (en) * | 1980-12-18 | 1990-03-06 | Schering Corporation | Substituted dipeptides as inhibitors of enkephalinases |
| US4757151A (en) * | 1985-11-14 | 1988-07-12 | Warner-Lambert Company | 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl] |
| DE3823464A1 (de) * | 1988-07-11 | 1990-01-18 | Asta Pharma Ag | Neue tryptophandipeptide |
| GB9508195D0 (en) * | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
| DE19943508A1 (de) * | 1999-09-10 | 2001-03-15 | Morphochem Ag | 3-Vinylpyrol-Derivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1570140A (en) * | 1976-12-28 | 1980-06-25 | Troponwerke Gmbh & Co Kg | Tumour-resolving and histolytic medicaments comprising dehydrooligropeptides |
| NO774303L (no) * | 1976-12-28 | 1978-06-29 | Troponwerke Gmbh & Co Kg | Nye dehydrooligopeptider, fremgangsmaate til deres fremstilling samt deres anvendelse som legemiddel |
-
1979
- 1979-02-07 DE DE19792904512 patent/DE2904512A1/de not_active Withdrawn
-
1980
- 1980-01-22 NO NO800151A patent/NO149103B/no unknown
- 1980-01-23 US US06/114,468 patent/US4285935A/en not_active Expired - Lifetime
- 1980-01-28 EP EP80100423A patent/EP0017705B1/de not_active Expired
- 1980-01-28 DE DE8080100423T patent/DE3060669D1/de not_active Expired
- 1980-01-28 AT AT80100423T patent/ATE1352T1/de not_active IP Right Cessation
- 1980-02-04 IL IL59295A patent/IL59295A/xx unknown
- 1980-02-05 GR GR61130A patent/GR73033B/el unknown
- 1980-02-05 FI FI800350A patent/FI800350A7/fi not_active Application Discontinuation
- 1980-02-05 JP JP1209980A patent/JPS55105654A/ja active Pending
- 1980-02-05 CA CA000345085A patent/CA1147725A/en not_active Expired
- 1980-02-06 DK DK52080A patent/DK52080A/da not_active Application Discontinuation
- 1980-02-06 ES ES488301A patent/ES8203334A1/es not_active Expired
- 1980-02-07 HU HU8080280A patent/HU181052B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3060669D1 (en) | 1982-09-09 |
| ES488301A0 (es) | 1980-08-01 |
| DK52080A (da) | 1980-08-08 |
| EP0017705A1 (de) | 1980-10-29 |
| FI800350A7 (fi) | 1981-01-01 |
| NO800151L (no) | 1980-08-08 |
| JPS55105654A (en) | 1980-08-13 |
| EP0017705B1 (de) | 1982-07-21 |
| IL59295A (en) | 1982-12-31 |
| ATE1352T1 (de) | 1982-08-15 |
| NO149103B (no) | 1983-11-07 |
| CA1147725A (en) | 1983-06-07 |
| IL59295A0 (en) | 1980-05-30 |
| DE2904512A1 (de) | 1980-08-28 |
| US4285935A (en) | 1981-08-25 |
| HU181052B (en) | 1983-05-30 |
| GR73033B (es) | 1984-01-26 |
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