ES8105323A1 - Un procedimiento para la preparacion de derivados del acido clarulanico - Google Patents
Un procedimiento para la preparacion de derivados del acido clarulanicoInfo
- Publication number
- ES8105323A1 ES8105323A1 ES491578A ES491578A ES8105323A1 ES 8105323 A1 ES8105323 A1 ES 8105323A1 ES 491578 A ES491578 A ES 491578A ES 491578 A ES491578 A ES 491578A ES 8105323 A1 ES8105323 A1 ES 8105323A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pharmaceutical compositions
- acid derivatives
- clavulanic acid
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical class OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 239000003781 beta lactamase inhibitor Substances 0.000 abstract 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Pyrane Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE ACIDO CLAVULANICO. CONSISTE EN HACER REACCIONAR UN ESTER ESCINDIBLE DE UN COMPUESTO (I) CON UN TIOLATO DE UN TIOL DE FORMULA HS-CH=CH-NH-CO-R, PARA PRODUCIR UN ESTER ESCINDIBLE DEL COMPUESTO (II). A CONTINUACION, Y OPCIONALMENTE, SE REALIZA UNA O MAS DE LAS SIGUIENTES ETAPAS: 1. OXIDAR EL ATOMO DE AZUFRE (X) A UN GRUPO SO O SO2. 2. SEPARAR EL ESTER ESCINDIBLE. 3. CONVERTIR EL COMPUESTO (II) EN UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES O EN UNO DE SUS ESTERES HIDROLIZABLES <<IN VIVO>>. 4. CONVERTIR UNA SAL DEL COMPUESTO II EN EL ACIDO LIBRE. 5. HOMERIZAR EL DOBLE ENLACE. *FORMULA* AGENTES INHIBIDORES DE LA BETA-LACTAMASA Y ANTIBACTERIANOS. N
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7917210 | 1979-05-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8105323A1 true ES8105323A1 (es) | 1981-05-16 |
| ES491578A0 ES491578A0 (es) | 1981-05-16 |
Family
ID=10505223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES491578A Granted ES491578A0 (es) | 1979-05-17 | 1980-05-16 | Un procedimiento para la preparacion de derivados del acido clarulanico |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4372962A (es) |
| EP (1) | EP0019457B1 (es) |
| JP (1) | JPS55157587A (es) |
| AT (1) | ATE6514T1 (es) |
| AU (1) | AU5850380A (es) |
| DE (1) | DE3066808D1 (es) |
| DK (1) | DK215680A (es) |
| ES (1) | ES491578A0 (es) |
| FI (1) | FI801585A7 (es) |
| GR (1) | GR68459B (es) |
| IL (1) | IL60056A0 (es) |
| NO (1) | NO801474L (es) |
| NZ (1) | NZ193687A (es) |
| ZA (1) | ZA802913B (es) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL50080A (en) * | 1975-07-29 | 1979-07-25 | Beecham Group Ltd | 4-oxa-1-azabicyclo(3.2.0)heptan-7-one-2-car boxylic acid derivatives and their preparation |
| PT66071B (en) * | 1976-01-31 | 1978-06-23 | Beecham Group Ltd | Clavulanic acid thioethers |
| JPS52125191A (en) * | 1976-02-27 | 1977-10-20 | Glaxo Lab Ltd | Novel compound and process for preparing same |
| US4215128A (en) * | 1977-09-20 | 1980-07-29 | Beecham Group Limited | Clavulanic acid derivatives their preparation and use |
-
1980
- 1980-05-12 IL IL60056A patent/IL60056A0/xx unknown
- 1980-05-12 NZ NZ193687A patent/NZ193687A/xx unknown
- 1980-05-13 US US06/149,322 patent/US4372962A/en not_active Expired - Lifetime
- 1980-05-14 AT AT80301577T patent/ATE6514T1/de not_active IP Right Cessation
- 1980-05-14 DE DE8080301577T patent/DE3066808D1/de not_active Expired
- 1980-05-14 EP EP80301577A patent/EP0019457B1/en not_active Expired
- 1980-05-15 FI FI801585A patent/FI801585A7/fi not_active Application Discontinuation
- 1980-05-15 GR GR61958A patent/GR68459B/el unknown
- 1980-05-16 NO NO801474A patent/NO801474L/no unknown
- 1980-05-16 ES ES491578A patent/ES491578A0/es active Granted
- 1980-05-16 DK DK215680A patent/DK215680A/da unknown
- 1980-05-16 ZA ZA00802913A patent/ZA802913B/xx unknown
- 1980-05-16 AU AU58503/80A patent/AU5850380A/en not_active Abandoned
- 1980-05-16 JP JP6516380A patent/JPS55157587A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ATE6514T1 (de) | 1984-03-15 |
| EP0019457A2 (en) | 1980-11-26 |
| DE3066808D1 (en) | 1984-04-12 |
| EP0019457A3 (en) | 1981-01-28 |
| ZA802913B (en) | 1981-05-27 |
| IL60056A0 (en) | 1980-07-31 |
| US4372962A (en) | 1983-02-08 |
| AU5850380A (en) | 1980-11-20 |
| FI801585A7 (fi) | 1980-11-18 |
| NZ193687A (en) | 1982-12-21 |
| JPS55157587A (en) | 1980-12-08 |
| DK215680A (da) | 1981-01-20 |
| EP0019457B1 (en) | 1984-03-07 |
| ES491578A0 (es) | 1981-05-16 |
| NO801474L (no) | 1980-11-18 |
| GR68459B (es) | 1981-12-30 |
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