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ES8103028A1 - Procedimiento para la obtencion de nuevos peptidos del tipo somatostatina - Google Patents

Procedimiento para la obtencion de nuevos peptidos del tipo somatostatina

Info

Publication number
ES8103028A1
ES8103028A1 ES489565A ES489565A ES8103028A1 ES 8103028 A1 ES8103028 A1 ES 8103028A1 ES 489565 A ES489565 A ES 489565A ES 489565 A ES489565 A ES 489565A ES 8103028 A1 ES8103028 A1 ES 8103028A1
Authority
ES
Spain
Prior art keywords
preparation
phe
trp
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES489565A
Other languages
English (en)
Other versions
ES489565A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES489565A0 publication Critical patent/ES489565A0/es
Publication of ES8103028A1 publication Critical patent/ES8103028A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/065—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for hydroxy functions, not being part of carboxy functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE NUEVOS PEPTIDOS DEL TIPO SOMATOSTATINA DE FORMULA GENERAL: *FORMULA* DONDE BMP SIGNIFICA EL RESTO DESAMINOCISTEINA, X SIGNIFICA ASN O HIS; TRP SIGNIFICA D-TRP, QUE PUEDE ESTAR SUSTITUIDO EN EL ANILLO BENCENICO POR UN ATOMO DE HALOGENO E Y SIGNIFICA EL RESTO DE UN ALFA-AMINOACIDO SECUNDARIO CON UN MAXIMO DE 8 ATOMOS DE CARBONO DE LAS CORRESPONDIENTES PEPTIDAMIDAS, ASI COMO DE LAS SALES DE ADICION DE ACIDO Y COMPLEJOS DE ESTOS COMPUESTOS. EL COMPUESTO DESEADO SE OBTIENE POR DISOCIACION DEL COMPUESTO DE FORMULA: BMP(C)-LYS(A)-X-PHE-PHE-TRP-LYS(A'')-THR(B'')-PHE-THR(B'')-Y-CYS(C'')-D DONDE A,A'',B,B'',C,C'' Y D SON DISTINTOS GRUPOS PROTECTORES. Q
ES489565A 1979-03-16 1980-03-14 Procedimiento para la obtencion de nuevos peptidos del tipo somatostatina Expired ES8103028A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH250679 1979-03-16

Publications (2)

Publication Number Publication Date
ES489565A0 ES489565A0 (es) 1981-02-16
ES8103028A1 true ES8103028A1 (es) 1981-02-16

Family

ID=4235326

Family Applications (1)

Application Number Title Priority Date Filing Date
ES489565A Expired ES8103028A1 (es) 1979-03-16 1980-03-14 Procedimiento para la obtencion de nuevos peptidos del tipo somatostatina

Country Status (17)

Country Link
US (1) US4316890A (es)
EP (1) EP0017760B1 (es)
JP (1) JPS55124748A (es)
KR (1) KR830001872A (es)
AT (1) ATE3283T1 (es)
AU (1) AU5646280A (es)
CA (1) CA1140117A (es)
DD (1) DD151059A5 (es)
DE (1) DE3063028D1 (es)
ES (1) ES8103028A1 (es)
FI (1) FI800795A7 (es)
GR (1) GR67655B (es)
IL (1) IL59620A (es)
NO (1) NO800743L (es)
NZ (1) NZ193129A (es)
PT (1) PT70951A (es)
ZA (1) ZA801520B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4612302A (en) * 1983-11-14 1986-09-16 Brigham And Women's Hospital Clinical use of somatostatin analogues
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
CA2161108A1 (en) * 1993-04-23 1994-11-10 Herbert J. Evans Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5928896A (en) * 1993-04-23 1999-07-27 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US5952465A (en) * 1993-04-23 1999-09-14 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US6258550B1 (en) 1993-04-23 2001-07-10 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5965698A (en) * 1993-04-23 1999-10-12 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US6084066A (en) * 1993-10-29 2000-07-04 Virginia Commonwealth University Polypetides that include conformation-constraining groups which flank a protein-protein interaction site
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
ES2202864T3 (es) 1997-05-13 2004-04-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Agonistas de la somatostatina para disminuir el peso corporal.
CA2289499C (en) * 1997-05-13 2010-02-23 Michael Anthony Cawthorne Somatostatin and somatostatin agonists for treating insulin insensitivity and syndrome x
EP0981364B1 (en) * 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Method and compositions for treating hyperlipidemia
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
ATE424414T1 (de) 2001-06-08 2009-03-15 Sod Conseils Rech Applic Chimere somatostatin-dopamin-analoga
EP1624884A4 (en) 2003-04-22 2009-08-05 Ipsen Pharma SOMATOSTATIN VECTORS
CN102083451A (zh) 2008-06-12 2011-06-01 赛恩泰新公司 癌症的抑制
JP5728380B2 (ja) 2008-06-12 2015-06-03 シンタクシン リミテッドＳｙｎｔａｘｉｎ Ｌｉｍｉｔｅｄ 神経内分泌疾患の抑制
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
JP6869720B2 (ja) 2013-06-13 2021-05-12 アンチセンス セラピューティクス リミテッド 併用療法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4020157A (en) * 1975-07-08 1977-04-26 Ayerst Mckenna And Harrison Ltd. Shortened analogs of somatostatin
US4372884A (en) * 1975-08-06 1983-02-08 The Salk Institute For Biological Studies Pharmaceutically active peptides
NL7607987A (nl) * 1975-08-08 1977-02-10 Merck & Co Inc Werkwijze voor het bereiden van peptiden.
US4122077A (en) * 1976-12-17 1978-10-24 American Home Products Corporation Somatostatin analogs
US4098782A (en) * 1977-03-14 1978-07-04 American Home Products Corporation (His5)-somatostatin and analogues thereof
US4115554A (en) * 1977-08-29 1978-09-19 Merck & Co., Inc. Somatostatin analogs
GB2019411B (en) * 1978-04-24 1982-06-16 American Home Prod Peptides related to somatostatin

Also Published As

Publication number Publication date
FI800795A7 (fi) 1981-01-01
JPS55124748A (en) 1980-09-26
GR67655B (es) 1981-09-02
AU5646280A (en) 1980-09-18
EP0017760A1 (de) 1980-10-29
ES489565A0 (es) 1981-02-16
IL59620A (en) 1983-07-31
PT70951A (en) 1980-04-01
EP0017760B1 (de) 1983-05-11
NO800743L (no) 1980-09-17
DE3063028D1 (en) 1983-06-16
US4316890A (en) 1982-02-23
CA1140117A (en) 1983-01-25
ZA801520B (en) 1981-03-25
DD151059A5 (de) 1981-09-30
ATE3283T1 (de) 1983-05-15
NZ193129A (en) 1982-06-29
KR830001872A (ko) 1983-05-19
IL59620A0 (en) 1980-06-30

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