ES8102148A1 - Metodo de preparar 3-0-(beta-d-glucuronopiranosil)-sojasapo-genol b y similares - Google Patents
Metodo de preparar 3-0-(beta-d-glucuronopiranosil)-sojasapo-genol b y similaresInfo
- Publication number
- ES8102148A1 ES8102148A1 ES487982A ES487982A ES8102148A1 ES 8102148 A1 ES8102148 A1 ES 8102148A1 ES 487982 A ES487982 A ES 487982A ES 487982 A ES487982 A ES 487982A ES 8102148 A1 ES8102148 A1 ES 8102148A1
- Authority
- ES
- Spain
- Prior art keywords
- beta
- alcoholysis
- sojasapo
- glucuronopyrosil
- genol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000006136 alcoholysis reaction Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000027932 Collagen disease Diseases 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- 244000068988 Glycine max Species 0.000 abstract 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003171 anti-complementary effect Effects 0.000 abstract 1
- 230000005784 autoimmunity Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 230000000552 rheumatic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 3-O-(BETA-D-GLUCOROPIRANOSIL)-SOJASAPOGENOL B, DE FORMULA (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. COMPRENDE LA SEPARACION DE SOJASAPONINA DE SEMILLAS DE SOJA Y LA ALCOHOLISIS DE DICHO COMPUESTO CON UN ALCOHOL INFERIOR, EN PRESENCIA DE UN ACIDO PARA FORMAR 3-O-(6-O-ALQUIL-BETA-D-GLUCOROPIRANOSIL)-SOJASAPOGENOL B, QUE POSTERIORMENTE ES HIDROLIZADO. LA ALCOHOLISIS PUEDE EFECTUARSE, SEGUN LOS CASOS, DESDE LA TEMPERATURA AMBIENTE HASTA UNOS 100GC, Y LA HIDROLISIS TIENE LUGAR EN UN DISOLVENTE INERTE, EN PRESENCIA DE CATALIZADORES Y EN UN MARGEN DE TEMPERATURA QUE VA DESDE LA AMBIENTE HASTA 150GC. ESTOS COMPUESTOS TIENEN ACTIVIDAD ANTICOMPLEMENTARIA Y SON DE UTILIDAD COMO AGENTES TERAPEUTICOS EN ENFERMEDADES DE AUTOINMUNIDAD, REUMATICAS Y DEL COLAGENO. *FORMULA*
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP53038536A JPS5822120B2 (ja) | 1978-03-31 | 1978-03-31 | ３−０−（β−Ｄ−グルクロノピラノシル）−ソ−ヤサポゲノ−ルＢ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8102148A1 true ES8102148A1 (es) | 1981-01-16 |
| ES487982A0 ES487982A0 (es) | 1981-01-16 |
Family
ID=12527996
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES478874A Expired ES478874A1 (es) | 1978-03-31 | 1979-03-22 | Procedimiento de preparar 3-0(beta -d-glucuronopiranosil)- soja-sapogenol b. |
| ES487982A Granted ES487982A0 (es) | 1978-03-31 | 1980-01-24 | Metodo de preparar 3-0-(beta-d-glucuronopiranosil)-sojasapo-genol b y similares |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES478874A Expired ES478874A1 (es) | 1978-03-31 | 1979-03-22 | Procedimiento de preparar 3-0(beta -d-glucuronopiranosil)- soja-sapogenol b. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4217345A (es) |
| JP (1) | JPS5822120B2 (es) |
| AR (1) | AR227624A1 (es) |
| AT (1) | AT369426B (es) |
| AU (1) | AU527201B2 (es) |
| BE (2) | BE875105A (es) |
| CA (1) | CA1128498A (es) |
| CH (1) | CH640868A5 (es) |
| DE (1) | DE2911353A1 (es) |
| DK (1) | DK162102C (es) |
| ES (2) | ES478874A1 (es) |
| FI (1) | FI67559C (es) |
| FR (1) | FR2421179A1 (es) |
| GB (1) | GB2020290B (es) |
| IT (1) | IT1126812B (es) |
| MX (1) | MX6305E (es) |
| NL (1) | NL7902449A (es) |
| NO (1) | NO154584C (es) |
| PH (1) | PH16275A (es) |
| PT (1) | PT69423A (es) |
| SE (1) | SE434269B (es) |
| SU (2) | SU1074408A3 (es) |
| ZA (1) | ZA791061B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU528415B2 (en) * | 1978-03-31 | 1983-04-28 | Otsuka Pharmaceutical Co., Ltd. | Anticomplementary agents |
| DE3040246C2 (de) * | 1979-10-29 | 1985-01-10 | Osaka Chemical Laboratory Co., Ltd., Osaka | Sojasaponine A↓1↓ und A↓2↓ und ihre Verwendung |
| JPH0621072B2 (ja) * | 1986-11-12 | 1994-03-23 | 呉羽化学工業株式会社 | エストラジオ−ル誘導体よりなる免疫調節剤 |
| USD372238S (en) | 1995-07-18 | 1996-07-30 | Mussa Khiar | Dual simultaneous-use telephone housing |
| US6784159B2 (en) * | 2000-09-29 | 2004-08-31 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture | Triterpene saponins from soybeans for treating kidney disease |
| EP1422509A1 (en) * | 2002-11-01 | 2004-05-26 | Streck Laboratories, Inc. | Lysing Reagent and Method of Lysing Red Blood Cells for Hematology |
| JP4960096B2 (ja) * | 2003-09-22 | 2012-06-27 | ペントラコール ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｉｌ−６の生物学的効果を減じる化合物の使用 |
| US20070141121A1 (en) * | 2005-12-20 | 2007-06-21 | Calton Gary J | Method of treating kidney disease |
| BR112013032777A2 (pt) * | 2011-06-28 | 2017-01-24 | J Oil Mills Inc | composição de sapogenol de soja |
| CN106589043B (zh) * | 2015-10-16 | 2019-02-26 | 复旦大学 | 芳基取代丙烯酰基三萜类化合物在制备抗补体药物中的用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5377001A (en) * | 1976-11-16 | 1978-07-08 | Otsuka Pharmaceut Co Ltd | New material and its preparation |
| JPS5399314A (en) * | 1977-02-04 | 1978-08-30 | Otsuka Pharmaceut Co Ltd | Therapeutic agent for nephritis |
| AU528415B2 (en) * | 1978-03-31 | 1983-04-28 | Otsuka Pharmaceutical Co., Ltd. | Anticomplementary agents |
-
1978
- 1978-03-31 JP JP53038536A patent/JPS5822120B2/ja not_active Expired
-
1979
- 1979-03-07 ZA ZA791061A patent/ZA791061B/xx unknown
- 1979-03-09 AU AU44995/79A patent/AU527201B2/en not_active Ceased
- 1979-03-22 DE DE19792911353 patent/DE2911353A1/de active Granted
- 1979-03-22 ES ES478874A patent/ES478874A1/es not_active Expired
- 1979-03-26 BE BE0/194225A patent/BE875105A/xx not_active IP Right Cessation
- 1979-03-26 NO NO790994A patent/NO154584C/no unknown
- 1979-03-26 AR AR275945A patent/AR227624A1/es active
- 1979-03-26 BE BE0/194226A patent/BE875106A/xx not_active IP Right Cessation
- 1979-03-27 GB GB7910739A patent/GB2020290B/en not_active Expired
- 1979-03-27 FI FI791011A patent/FI67559C/fi not_active IP Right Cessation
- 1979-03-28 CH CH285979A patent/CH640868A5/de not_active IP Right Cessation
- 1979-03-28 CA CA324,367A patent/CA1128498A/en not_active Expired
- 1979-03-28 DK DK126679A patent/DK162102C/da not_active IP Right Cessation
- 1979-03-29 AT AT0236079A patent/AT369426B/de not_active IP Right Cessation
- 1979-03-29 NL NL7902449A patent/NL7902449A/xx not_active Application Discontinuation
- 1979-03-30 PH PH22339A patent/PH16275A/en unknown
- 1979-03-30 US US06/025,518 patent/US4217345A/en not_active Expired - Lifetime
- 1979-03-30 IT IT48551/79A patent/IT1126812B/it active
- 1979-03-30 FR FR7908121A patent/FR2421179A1/fr active Granted
- 1979-03-30 SE SE7902866A patent/SE434269B/sv not_active IP Right Cessation
- 1979-03-30 MX MX797843U patent/MX6305E/es unknown
- 1979-03-30 PT PT69423A patent/PT69423A/pt unknown
- 1979-03-30 SU SU792745040A patent/SU1074408A3/ru active
-
1980
- 1980-01-24 ES ES487982A patent/ES487982A0/es active Granted
- 1980-07-31 SU SU802954186A patent/SU1190989A3/ru active
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |