ES549920A0 - Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimidazo(2,1-b) quinazolinil)-oxialquilamidas - Google Patents

Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimidazo(2,1-b) quinazolinil)-oxialquilamidas

Info

Publication number: ES549920A0
Authority: ES; Spain
Prior art keywords: quinazolinil; oxialquilamidas; tetrahydroimidazo; oxo; preparing
Prior art date: 1984-02-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES549920A

Other languages

English (en)

Other versions

ES8606297A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Syntex USA LLC

Original Assignee

Syntex USA LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-02-15

Filing date

1985-12-13

Publication date

1986-04-16

1985-12-13 Application filed by Syntex USA LLC filed Critical Syntex USA LLC

1986-04-16 Publication of ES549920A0 publication Critical patent/ES549920A0/es

1986-04-16 Publication of ES8606297A1 publication Critical patent/ES8606297A1/es

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ES549920A 1984-02-15 1985-12-13 Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimidazo(2,1-b) quinazolinil)-oxialquilamidas Expired ES8606297A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US58040984A	1984-02-15	1984-02-15

Publications (2)

Publication Number	Publication Date
ES549920A0 true ES549920A0 (es)	1986-04-16
ES8606297A1 ES8606297A1 (es)	1986-04-16

Family

ID=24320992

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES540403A Expired ES8607299A1 (es)	1984-02-15	1985-02-14	Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimida- zo(2,1-b)quinazolinil)-oxialquilamidas
ES549920A Expired ES8606297A1 (es)	1984-02-15	1985-12-13	Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimidazo(2,1-b) quinazolinil)-oxialquilamidas

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ES540403A Expired ES8607299A1 (es)	1984-02-15	1985-02-14	Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimida- zo(2,1-b)quinazolinil)-oxialquilamidas

Country Status (13)

Country	Link
US (1)	US4690925A (es)
EP (1)	EP0153152A3 (es)
JP (1)	JPS60193991A (es)
AU (1)	AU581205B2 (es)
CA (1)	CA1254557A (es)
DK (1)	DK69285A (es)
ES (2)	ES8607299A1 (es)
FI (1)	FI81578C (es)
HU (2)	HU191316B (es)
IL (1)	IL74349A (es)
NO (1)	NO164654C (es)
NZ (1)	NZ211117A (es)
ZA (1)	ZA851131B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4490371A (en) *	1983-02-16	1984-12-25	Syntex (U.S.A.) Inc.	N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
ES8607299A1 (es) *	1984-02-15	1986-06-01	Syntex Inc	Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimida- zo(2,1-b)quinazolinil)-oxialquilamidas
US4837239A (en) *	1985-08-23	1989-06-06	Syntex (U.S.A.) Inc.	Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
US4775674A (en) *	1986-05-23	1988-10-04	Bristol-Myers Company	Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) *	1986-07-08	1987-10-20	Bristol-Myers Company	7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4943573A (en) *	1989-11-01	1990-07-24	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
EP0593567B1 (de)	1991-07-05	1996-08-28	Byk Gulden Lomberg Chemische Fabrik Gmbh	Verwendung substituierter pyridazine gegen dermatosen
HUT66324A (en) *	1991-07-29	1994-11-28	Warner Lambert Co	Quinazoline derivatives as acetylcholinesterase inhibitors and pharmaceutical compositions containing them
US5208237A (en) *	1992-04-03	1993-05-04	Bristol-Meyers Squibb Company	7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5196428A (en) *	1992-04-03	1993-03-23	Bristol-Myers Squibb Company	Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5348960A (en) *	1992-04-03	1994-09-20	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5158958A (en) *	1992-04-03	1992-10-27	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US7700608B2 (en)	2004-08-04	2010-04-20	Shire Holdings Ag	Quinazoline derivatives and their use in the treatment of thrombocythemia
US7910597B2 (en)	2006-11-28	2011-03-22	Shire Llc	Substituted quinazolines
US8304420B2 (en)	2006-11-28	2012-11-06	Shire Llc	Substituted quinazolines for reducing platelet count

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US31617A (en) *		1861-03-05		photo-uthcqfupheh
USRE31617E (en)	1972-02-04	1984-06-26	Bristol-Myers Company	Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
US3932407A (en) *	1973-11-19	1976-01-13	Bristol-Myers Company	Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
US4313947A (en) *	1974-06-24	1982-02-02	Otsuka Pharmaceutical Co., Ltd.	Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use
US4070470A (en) *	1974-06-24	1978-01-24	Otsuka Pharmaceutical Co., Ltd.	Platelet aggregation inhibiting carbostyrils, their compositions and method of use
US3983119A (en) *	1974-11-06	1976-09-28	Bristol-Myers Company	Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
US3983120A (en) *	1974-11-06	1976-09-28	Bristol-Myers Company	Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
US3988340A (en) *	1975-01-23	1976-10-26	Bristol-Myers Company	6-Alkoxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones and 7-alkoxymethyl-6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]quinazolin-2-ones
IE46852B1 (en) *	1977-06-10	1983-10-05	Otsuka Pharma Co Ltd	Novel carbostyril derivatives
NL7807507A (nl) *	1977-07-25	1979-01-29	Hoffmann La Roche	Tricyclische verbindingen.
JPS54163825A (en) *	1978-06-15	1979-12-26	Otsuka Pharma Co Ltd	Phosphoesterase inhibitor
US4208521A (en) *	1978-07-31	1980-06-17	Bristol-Myers Company	Process for the preparation of imidazo[2,1-b]quinazolinones
US4490371A (en) *	1983-02-16	1984-12-25	Syntex (U.S.A.) Inc.	N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
US4551459A (en) *	1983-02-16	1985-11-05	Syntex (U.S.A.) Inc.	Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides
JPS604186A (ja) *	1983-06-21	1985-01-10	Dai Ichi Seiyaku Co Ltd	イミダゾキナゾリン化合物
ES8607299A1 (es) *	1984-02-15	1986-06-01	Syntex Inc	Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimida- zo(2,1-b)quinazolinil)-oxialquilamidas

1985
- 1985-02-14 ES ES540403A patent/ES8607299A1/es not_active Expired
- 1985-02-14 DK DK69285A patent/DK69285A/da not_active Application Discontinuation
- 1985-02-14 ZA ZA851131A patent/ZA851131B/xx unknown
- 1985-02-14 JP JP60028116A patent/JPS60193991A/ja active Pending
- 1985-02-14 CA CA000474342A patent/CA1254557A/en not_active Expired
- 1985-02-14 NO NO850564A patent/NO164654C/no unknown
- 1985-02-14 HU HU85551A patent/HU191316B/hu not_active IP Right Cessation
- 1985-02-14 AU AU38754/85A patent/AU581205B2/en not_active Ceased
- 1985-02-14 FI FI850618A patent/FI81578C/fi not_active IP Right Cessation
- 1985-02-14 EP EP85300977A patent/EP0153152A3/en not_active Withdrawn
- 1985-02-14 IL IL74349A patent/IL74349A/xx unknown
- 1985-02-14 HU HU864000A patent/HU193409B/hu not_active IP Right Cessation
- 1985-02-14 NZ NZ211117A patent/NZ211117A/en unknown
- 1985-05-15 US US06/734,633 patent/US4690925A/en not_active Expired - Fee Related
- 1985-12-13 ES ES549920A patent/ES8606297A1/es not_active Expired

Also Published As

Publication number	Publication date
US4690925A (en)	1987-09-01
HUT36122A (en)	1985-08-28
FI81578C (fi)	1990-11-12
AU581205B2 (en)	1989-02-16
NO164654C (no)	1990-10-31
NO164654B (no)	1990-07-23
ZA851131B (en)	1986-09-24
ES8606297A1 (es)	1986-04-16
AU3875485A (en)	1985-08-22
FI850618A0 (fi)	1985-02-14
FI81578B (fi)	1990-07-31
IL74349A (en)	1988-07-31
FI850618L (fi)	1985-08-16
EP0153152A2 (en)	1985-08-28
NO850564L (no)	1985-08-16
DK69285D0 (da)	1985-02-14
HU191316B (en)	1987-02-27
EP0153152A3 (en)	1987-07-15
DK69285A (da)	1985-08-16
JPS60193991A (ja)	1985-10-02
ES540403A0 (es)	1986-06-01
IL74349A0 (en)	1985-05-31
NZ211117A (en)	1987-10-30
CA1254557A (en)	1989-05-23
ES8607299A1 (es)	1986-06-01
HU193409B (en)	1987-10-28

Publication	Publication Date	Title
ES544204A0 (es)	1987-06-01	Procedimiento para preparar dialcoxipiridinas
ES540597A0 (es)	1986-04-16	Procedimiento para la obtencion de piridonas.
ES542976A0 (es)	1986-01-01	Procedimiento para preparar pirrolo-bencimidazoles
ES550113A0 (es)	1987-07-16	Procedimiento para preparar compuestos carbostirilicos
ES546314A0 (es)	1986-06-01	Procedimiento para preparar nuevos compuestos de 3-piridilo
ES539822A0 (es)	1986-05-16	Procedimiento para la preparacion de pirazolopiridinas.
ES550730A0 (es)	1987-05-01	Procedimiento para preparar poliesterpolioles
ES549920A0 (es)	1986-04-16	Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimidazo(2,1-b) quinazolinil)-oxialquilamidas
ES555561A0 (es)	1987-07-01	Procedimiento para preparar celalosporinas
MX162986B (es)	1991-07-30	Procedimiento para preparar n-formil-alfa-aspartil-fenilalanina
ES554373A0 (es)	1987-04-01	Procedimiento para preparar nuevos 1,2,4-triazolo-carbamatos
MX161361A (es)	1990-09-18	Procedimiento para preparar 1,6-naftiridin-2(1h)-onas
MX160612A (es)	1990-03-28	Procedimiento para preparar 3-carbonil-1-aminoalquil-1h-indoles
ES542342A0 (es)	1985-12-16	"procedimiento para preparar poli(tetrametilen-adipamida)".
ES548237A0 (es)	1986-05-16	Procedimiento para preparar n6-bicicloadenosinas
ES544622A0 (es)	1986-07-16	Procedimiento para preparar l-fenilalamina
ES552699A0 (es)	1987-10-16	Un procedimiento para la preparacion de 1-metil-4,5-dihidroorotil-histidil-prolinamida
ES544459A0 (es)	1986-07-16	Procedimiento para la obtencion de benzo -c- -1,8-naftiridi-nas
MX162329A (es)	1991-04-25	Procedimiento para preparar acilhidrazonas sulfeniladas
ES544074A0 (es)	1987-04-01	Procedimiento para preparar naftoxacinas
MX159907A (es)	1989-09-29	Procedimiento para preparar cloro-o-nitroanilinas
ES546802A0 (es)	1986-12-01	Procedimiento para preparar derivados de 7-oxo-4-tia-1-aza- biciclo(3,2,0)hept-2-eno
AR241137A1 (es)	1991-11-29	"procedimiento para preparar beta-metilen-2 o 3-tiofenetanamina".
NO164238C (no)	1990-09-12	Fremgangsmaate for fremstilling av pyridobenzodiazepinforbindelser.
ES540559A0 (es)	1987-06-16	Procedimiento para preparar diazepinoindoles.