ES545870A0 - PROCEDURE FOR PREPARING DERIVATIVES OF PYRROLIDINDIONA. - Google Patents
PROCEDURE FOR PREPARING DERIVATIVES OF PYRROLIDINDIONA.Info
- Publication number
- ES545870A0 ES545870A0 ES545870A ES545870A ES545870A0 ES 545870 A0 ES545870 A0 ES 545870A0 ES 545870 A ES545870 A ES 545870A ES 545870 A ES545870 A ES 545870A ES 545870 A0 ES545870 A0 ES 545870A0
- Authority
- ES
- Spain
- Prior art keywords
- pyrrolidindiona
- procedure
- preparing derivatives
- compounds
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 2,6-dimethyl-1-piperidinyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Materials For Photolithography (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Lubricants (AREA)
- Treatment Of Water By Ion Exchange (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Suspension Of Electric Lines Or Cables (AREA)
- Professional, Industrial, Or Sporting Protective Garments (AREA)
Abstract
This invention encompasses compounds of the formulaand pharmaceutically acceptable acid addition salts thereof wherein n is 2 or 3 and R and R, are n-propyl, isopropyl, or R, and R, together with N form a 2,6-dimethyl-1-piperidinyl group. The compounds of this invention are useful as antiarrhythmic agents.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/637,633 US4554353A (en) | 1984-08-03 | 1984-08-03 | 2,5-Pyrrolidinedione derivatives useful as antiarrhythmic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES545870A0 true ES545870A0 (en) | 1987-02-16 |
| ES8703421A1 ES8703421A1 (en) | 1987-02-16 |
Family
ID=24556766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES545870A Expired ES8703421A1 (en) | 1984-08-03 | 1985-08-02 | 2,5-Pyrrolidinedione derivatives useful as antiarrhythmic agents. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4554353A (en) |
| EP (1) | EP0170281B1 (en) |
| JP (1) | JPS6143164A (en) |
| AT (1) | ATE53575T1 (en) |
| AU (1) | AU581914B2 (en) |
| CA (1) | CA1270833C (en) |
| DE (1) | DE3578172D1 (en) |
| DK (1) | DK163661C (en) |
| ES (1) | ES8703421A1 (en) |
| FI (1) | FI80876C (en) |
| GR (1) | GR851890B (en) |
| IE (1) | IE60110B1 (en) |
| IL (1) | IL75985A (en) |
| NO (1) | NO166529C (en) |
| NZ (1) | NZ212955A (en) |
| PH (1) | PH20948A (en) |
| PT (1) | PT80905B (en) |
| ZA (1) | ZA855860B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USD973876S1 (en) * | 2020-03-18 | 2022-12-27 | Stephen A. Young | Blood sampling device |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH306905A (en) * | 1951-09-11 | 1955-04-30 | Ciba Geigy | Process for the preparation of a new dioxopyrrolidine. |
| US2666060A (en) * | 1951-09-11 | 1954-01-12 | Ciba Pharm Prod Inc | 1, 3-bisaminoalkyl-3-phenyl-2, 5-dioxopyrrolidines |
| FR1079802A (en) * | 1952-02-26 | 1954-12-02 | Parke Davis & Co | Manufacture of succinimide derivatives |
-
1984
- 1984-08-03 US US06/637,633 patent/US4554353A/en not_active Expired - Fee Related
-
1985
- 1985-08-01 AU AU45693/85A patent/AU581914B2/en not_active Ceased
- 1985-08-01 NZ NZ212955A patent/NZ212955A/en unknown
- 1985-08-01 EP EP85109680A patent/EP0170281B1/en not_active Expired - Lifetime
- 1985-08-01 PH PH32590A patent/PH20948A/en unknown
- 1985-08-01 IL IL75985A patent/IL75985A/en not_active IP Right Cessation
- 1985-08-01 DE DE8585109680T patent/DE3578172D1/en not_active Expired - Fee Related
- 1985-08-01 AT AT85109680T patent/ATE53575T1/en active
- 1985-08-01 CA CA487944A patent/CA1270833C/en not_active Expired
- 1985-08-01 GR GR851890A patent/GR851890B/el unknown
- 1985-08-02 JP JP60171008A patent/JPS6143164A/en active Granted
- 1985-08-02 ZA ZA855860A patent/ZA855860B/en unknown
- 1985-08-02 NO NO853069A patent/NO166529C/en unknown
- 1985-08-02 IE IE193285A patent/IE60110B1/en not_active IP Right Cessation
- 1985-08-02 DK DK353785A patent/DK163661C/en not_active IP Right Cessation
- 1985-08-02 PT PT80905A patent/PT80905B/en not_active IP Right Cessation
- 1985-08-02 ES ES545870A patent/ES8703421A1/en not_active Expired
- 1985-08-02 FI FI852990A patent/FI80876C/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK353785D0 (en) | 1985-08-02 |
| FI80876C (en) | 1990-08-10 |
| DK163661B (en) | 1992-03-23 |
| CA1270833A (en) | 1990-06-26 |
| AU4569385A (en) | 1986-02-06 |
| NO853069L (en) | 1986-02-04 |
| IE60110B1 (en) | 1994-06-01 |
| JPH0566942B2 (en) | 1993-09-22 |
| PH20948A (en) | 1987-06-10 |
| PT80905B (en) | 1987-09-30 |
| AU581914B2 (en) | 1989-03-09 |
| IL75985A (en) | 1988-07-31 |
| CA1270833C (en) | 1990-06-26 |
| JPS6143164A (en) | 1986-03-01 |
| FI852990A0 (en) | 1985-08-02 |
| IL75985A0 (en) | 1985-12-31 |
| NZ212955A (en) | 1988-03-30 |
| NO166529C (en) | 1991-08-07 |
| EP0170281B1 (en) | 1990-06-13 |
| US4554353A (en) | 1985-11-19 |
| ATE53575T1 (en) | 1990-06-15 |
| EP0170281A3 (en) | 1986-06-25 |
| ZA855860B (en) | 1986-10-29 |
| FI80876B (en) | 1990-04-30 |
| DE3578172D1 (en) | 1990-07-19 |
| FI852990L (en) | 1986-02-04 |
| GR851890B (en) | 1985-12-09 |
| EP0170281A2 (en) | 1986-02-05 |
| DK163661C (en) | 1992-08-24 |
| DK353785A (en) | 1986-02-04 |
| ES8703421A1 (en) | 1987-02-16 |
| IE851932L (en) | 1986-02-03 |
| PT80905A (en) | 1985-09-01 |
| NO166529B (en) | 1991-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20010402 |