ES532920A0 - A PROCEDURE FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINONES - Google Patents
A PROCEDURE FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINONESInfo
- Publication number
- ES532920A0 ES532920A0 ES532920A ES532920A ES532920A0 ES 532920 A0 ES532920 A0 ES 532920A0 ES 532920 A ES532920 A ES 532920A ES 532920 A ES532920 A ES 532920A ES 532920 A0 ES532920 A0 ES 532920A0
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- salts
- lower alkyl
- substd
- quat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 3
- PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 abstract 2
- -1 amine salt Chemical class 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 239000003513 alkali Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 150000001350 alkyl halides Chemical class 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001414 amino alcohols Chemical class 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000496 cardiotonic agent Substances 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 abstract 1
- 229940124550 renal vasodilator Drugs 0.000 abstract 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Manufacture Of Tobacco Products (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
Cpds. of formula (I) and their quat. salts with alkyl halides, alkali (ne earth) metal salts and the amine salt, aminoalcohol salts and aminoacid salts are new. In (I) R1 is H, NH2 or N02; R2 is H, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl or bicycloalkyl; R3 and R4 are H, lower alkyl, or aryl (opt. substd. by alkyl, lower alkoxy or OH); R5 is H, lower alkyl, or opt. substd. benzyl, provided that when R5 is other than H, the cpd. is a quat. salt; X is benzyl, COOH, alkoxycarbonyl, CN, CONH2, methane sulphonyl, formyl, alkanoyl, aroyl, heteroaroyl or heteroaryl; and Y and Z are H or OH, at least one being OH and when both are OH, they are in the 5,6- or 6,7- posn. Intermediates of formula (II) are also new. (R6 is lower alkyl; and R7 is H or is absent). Cpds. (I) are renal vasodilators and cardiovascular agents, and some intermediates in their prepn. are cardiotonic agents. Dose is 15-300 mg/kg.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/430,552 US4490374A (en) | 1982-09-30 | 1982-09-30 | 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8507512A1 ES8507512A1 (en) | 1985-09-01 |
| ES532920A0 true ES532920A0 (en) | 1985-09-01 |
Family
ID=23708017
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES526133A Expired ES8503671A1 (en) | 1982-09-30 | 1983-09-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
| ES532920A Granted ES532920A0 (en) | 1982-09-30 | 1984-05-29 | A PROCEDURE FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINONES |
| ES532918A Expired ES8507510A1 (en) | 1982-09-30 | 1984-05-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
| ES532919A Expired ES8507511A1 (en) | 1982-09-30 | 1984-05-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES526133A Expired ES8503671A1 (en) | 1982-09-30 | 1983-09-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532918A Expired ES8507510A1 (en) | 1982-09-30 | 1984-05-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
| ES532919A Expired ES8507511A1 (en) | 1982-09-30 | 1984-05-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
Country Status (13)
| Country | Link |
|---|---|
| KR (1) | KR840006218A (en) |
| AT (2) | ATE58531T1 (en) |
| DE (2) | DE3382013D1 (en) |
| ES (4) | ES8503671A1 (en) |
| HU (1) | HU192242B (en) |
| IL (1) | IL69849A (en) |
| NO (1) | NO833541L (en) |
| NZ (1) | NZ205685A (en) |
| PH (2) | PH19508A (en) |
| RO (2) | RO87466B (en) |
| SG (1) | SG31887G (en) |
| YU (2) | YU196983A (en) |
| ZW (1) | ZW20883A1 (en) |
-
1983
- 1983-09-21 NZ NZ205685A patent/NZ205685A/en unknown
- 1983-09-28 PH PH29609A patent/PH19508A/en unknown
- 1983-09-28 IL IL69849A patent/IL69849A/en unknown
- 1983-09-29 DE DE8686201912T patent/DE3382013D1/en not_active Expired - Lifetime
- 1983-09-29 AT AT86201912T patent/ATE58531T1/en not_active IP Right Cessation
- 1983-09-29 ZW ZW208/83A patent/ZW20883A1/en unknown
- 1983-09-29 RO RO112200A patent/RO87466B/en unknown
- 1983-09-29 NO NO833541A patent/NO833541L/en unknown
- 1983-09-29 RO RO83116473A patent/RO89787A/en unknown
- 1983-09-29 ES ES526133A patent/ES8503671A1/en not_active Expired
- 1983-09-29 AT AT83305895T patent/ATE34979T1/en active
- 1983-09-29 DE DE8383305895T patent/DE3376978D1/en not_active Expired
- 1983-09-29 HU HU833392A patent/HU192242B/en unknown
- 1983-09-30 KR KR1019830004638A patent/KR840006218A/en not_active Ceased
- 1983-09-30 YU YU01969/83A patent/YU196983A/en unknown
-
1984
- 1984-05-29 ES ES532920A patent/ES532920A0/en active Granted
- 1984-05-29 ES ES532918A patent/ES8507510A1/en not_active Expired
- 1984-05-29 ES ES532919A patent/ES8507511A1/en not_active Expired
-
1985
- 1985-05-24 PH PH32313A patent/PH21757A/en unknown
- 1985-12-11 YU YU01922/85A patent/YU192285A/en unknown
-
1987
- 1987-03-31 SG SG318/87A patent/SG31887G/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR840006218A (en) | 1984-11-22 |
| DE3376978D1 (en) | 1988-07-14 |
| PH19508A (en) | 1986-05-14 |
| RO87466A (en) | 1985-08-31 |
| ZW20883A1 (en) | 1985-05-01 |
| ATE58531T1 (en) | 1990-12-15 |
| IL69849A0 (en) | 1983-12-30 |
| PH21757A (en) | 1988-02-18 |
| SG31887G (en) | 1987-07-17 |
| IL69849A (en) | 1987-11-30 |
| ES526133A0 (en) | 1985-03-16 |
| RO87466B (en) | 1985-08-31 |
| ES532919A0 (en) | 1985-09-01 |
| YU192285A (en) | 1987-12-31 |
| ES532918A0 (en) | 1985-09-01 |
| ES8507512A1 (en) | 1985-09-01 |
| ES8507510A1 (en) | 1985-09-01 |
| ES8507511A1 (en) | 1985-09-01 |
| ES8503671A1 (en) | 1985-03-16 |
| HU192242B (en) | 1988-10-28 |
| NO833541L (en) | 1984-04-02 |
| YU196983A (en) | 1987-02-28 |
| DE3382013D1 (en) | 1991-01-03 |
| ATE34979T1 (en) | 1988-06-15 |
| NZ205685A (en) | 1987-03-31 |
| RO89787A (en) | 1986-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960506 |