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ES539072A0 - Un procedimiento para producir sales no hogroscopicas de l-carnitina y de alcanoil-l-carnitina - Google Patents

Un procedimiento para producir sales no hogroscopicas de l-carnitina y de alcanoil-l-carnitina

Info

Publication number
ES539072A0
ES539072A0 ES84539072A ES539072A ES539072A0 ES 539072 A0 ES539072 A0 ES 539072A0 ES 84539072 A ES84539072 A ES 84539072A ES 539072 A ES539072 A ES 539072A ES 539072 A0 ES539072 A0 ES 539072A0
Authority
ES
Spain
Prior art keywords
carnitine
hogroscopic
alcanoyl
salts
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES84539072A
Other languages
English (en)
Other versions
ES8601856A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT49594/83A external-priority patent/IT1172394B/it
Priority claimed from IT49123/84A external-priority patent/IT1178203B/it
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of ES8601856A1 publication Critical patent/ES8601856A1/es
Publication of ES539072A0 publication Critical patent/ES539072A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
ES84539072A 1983-12-28 1984-12-27 Un procedimiento para producir sales no hogroscopicas de l-carnitina y de alcanoil-l-carnitina Granted ES539072A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT49594/83A IT1172394B (it) 1983-12-28 1983-12-28 Sali della l-carnitina e di alcuni alcanoil derivati della l-carnitina e procedimento per la loro preparazione
IT49123/84A IT1178203B (it) 1984-11-06 1984-11-06 Orotati di alcanoil l-carnitine e procedimento per la loro preparazione

Publications (2)

Publication Number Publication Date
ES8601856A1 ES8601856A1 (es) 1985-11-16
ES539072A0 true ES539072A0 (es) 1985-11-16

Family

ID=26329370

Family Applications (1)

Application Number Title Priority Date Filing Date
ES84539072A Granted ES539072A0 (es) 1983-12-28 1984-12-27 Un procedimiento para producir sales no hogroscopicas de l-carnitina y de alcanoil-l-carnitina

Country Status (9)

Country Link
US (1) US4602039A (es)
EP (1) EP0150688B1 (es)
KR (1) KR900003020B1 (es)
CA (1) CA1252098A (es)
DE (1) DE3463261D1 (es)
DK (1) DK164543C (es)
ES (1) ES539072A0 (es)
GR (1) GR82612B (es)
IE (1) IE57942B1 (es)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
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IT1209564B (it) * 1984-06-29 1989-08-30 Magis Farmaceutici Derivati della l-carnitina o di l-acil carnitina.
IT1207994B (it) * 1986-01-03 1989-06-01 Therapicon Srl Sali idrosulubili di composti adattivita' antiinfiammatoria ed analgesica, loro preparazione ed utilizzo in composizioni farmaceutiche.
FR2596756B1 (fr) * 1986-04-04 1988-07-22 Elf Aquitaine Procede de purification de la carnitine
DE3635864A1 (de) * 1986-06-26 1988-05-05 Gerhard Gergely Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung
IT1208753B (it) * 1986-07-02 1989-07-10 Sigma Tau Ind Farmaceuti L-amminoacil derivati della l-carnitina, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' epatoprotettrice che li contengono
FR2619007B1 (fr) * 1987-08-07 1990-09-28 Dermatologiques Et Preparations cosmetiques a action lipolytique
DE3841664A1 (de) * 1988-12-10 1990-10-11 Fresenius Ag Nicht-hygroskopisches salz des l-carnitins
CA2018137C (en) * 1989-06-14 2000-01-11 Thomas Scholl L-carnitine magnesium citrate
US5073376A (en) * 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
CH679856A5 (es) * 1990-07-04 1992-04-30 Lonza Ag
IT1245699B (it) * 1991-05-29 1994-10-14 Sigma Tau Ind Farmaceuti Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi
IT1272290B (it) 1994-06-20 1997-06-16 Avantgarde Spa Sale della l-carnitina e composizioni farmaceutiche che lo contengono per il trattamento di affezioni cutanee
ATE200479T1 (de) * 1996-05-31 2001-04-15 Sigma Tau Ind Farmaceuti Stabile nichthygroskopische salze von l(- )carnitin und alkanoyl-l(-)carnitinen, verfahren zu ihrer herstellung und feste, oral verabreichbare zusammensetzungen,die sie enthalten
IT1289974B1 (it) * 1997-02-25 1998-10-19 Aldo Fassi Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
US6337320B1 (en) 1996-10-11 2002-01-08 Thione International, Inc. Reparatives for ultraviolet radiation skin damage
IT1291127B1 (it) * 1997-04-01 1998-12-29 Sigma Tau Ind Farmaceuti Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica
IT1291126B1 (it) * 1997-04-01 1998-12-29 Sigma Tau Ind Farmaceuti Composizioni solide atte alla somministrazione orale comprendenti sali non igroscopici della l-carnitina e delle alcanoil l-carnitine
IT1291133B1 (it) * 1997-04-07 1998-12-29 Sigma Tau Ind Farmaceuti Composizioni solide atte alla somministrazione orale comprendenti l-carnitina e alcanoil l-carnitine magnesio tartrato
IT1291134B1 (it) * 1997-04-08 1998-12-29 Sigma Tau Ind Farmaceuti Composizioni solide atte alla somministrazione orale comprendenti una alcanoil l-carnitina magnesio citrato
IT1291143B1 (it) * 1997-04-18 1998-12-29 Sigma Tau Ind Farmaceuti Composizioni solide atte alla somministrazione orale comprendenti l-carnitina colina tartrato o una alcanoil l-carnitina colina
IT1290600B1 (it) * 1997-04-30 1998-12-10 Sigma Tau Ind Farmaceuti Composizioni solide atte alla somministrazione orale comprendenti l-carnitina e alcanoil l-carnitine magnesio fumarato
US6138683A (en) * 1997-09-19 2000-10-31 Thione International, Inc. Smokeless tobacco products containing antioxidants
US5922346A (en) * 1997-12-01 1999-07-13 Thione International, Inc. Antioxidant preparation
EP0972516A1 (en) * 1998-06-25 2000-01-19 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Gastro-intestinal adverse effect-free composition comprising an L-carnitine replacement.
IT1299544B1 (it) 1998-07-03 2000-03-16 Sigma Tau Ind Farmaceuti Composizioni solide atte alla somministrazione orale comprendenti sali non igroscopici della l-carnitina e delle alcanoil l-carnitine
CA2349520C (en) 1998-10-30 2011-05-17 Science Applications International Corporation An agile network protocol for secure communications with assured system availability
EP1133289A1 (en) * 1998-11-26 2001-09-19 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Use of fumarate salt of l-carnitine or its alkanoyl derivatives in ischaemia
IT1312018B1 (it) * 1999-03-19 2002-04-04 Fassi Aldo Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina.
IT1305308B1 (it) * 1999-03-26 2001-05-04 Biosint S P A Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione
IT1306147B1 (it) * 1999-05-28 2001-05-30 Biosalts Srl Derivati di principi attivi ad attivita' terapeutica e/o nutrizionalee composizioni atte alla somministrazione orale contenenti tali
NZ517597A (en) * 1999-09-03 2003-11-28 Sigma Tau Healthscience S L-carnitine with a particle size that can pass through a 100 USBS mesh sieve, methods of preparing the same, compositions containing the same, and methods of using the same
US6914076B2 (en) * 2000-01-19 2005-07-05 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Treating chronic uremic patients undergoing periodical dialysis
US6429230B1 (en) 2000-01-19 2002-08-06 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Treating chronic uremic patients undergoing periodical dialysis
US6335369B1 (en) * 2000-01-19 2002-01-01 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Treating chronic uremic patients undergoing periodical dialysis
US6740338B1 (en) 2000-01-20 2004-05-25 Raj K. Chopra Reduced form of Cenzyme Q in high bioavailability stable oral dosage form
US8753675B1 (en) 2000-01-20 2014-06-17 Raj K. Chopra Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications
IT1317013B1 (it) * 2000-04-12 2003-05-26 Biosalts Srl Sostanze dolcificanti, particolarmente per il caffe' ed il the'.
IT1317042B1 (it) * 2000-06-14 2003-05-26 Biosalts Srl Fumarati doppi di una carnitina e creatina, e integratori alimentari,dietetici e farmaci che li contengono.
US6441050B1 (en) 2000-08-29 2002-08-27 Raj K. Chopra Palatable oral coenzyme Q liquid
ATE295690T1 (de) * 2000-08-29 2005-06-15 Lonza Ag Verfahren zur herstellung einer granulierbaren mischung und carnitin-magnesium-hydroxycitrat
IT1317924B1 (it) * 2000-10-31 2003-07-15 Sigma Tau Ind Farmaceuti Composizioni solide atte alla somministrazione orale comprendenti salinon igroscopici della l-carnitina e delle alcanoil l-carnitine con
ITRM20010030A1 (it) * 2001-01-23 2002-07-23 Aldo Fassi Sali di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per la loro pr
ITRM20010044A1 (it) * 2001-01-29 2002-07-29 Sigma Tau Healthscience Spa Integratore alimentare ad effetto dimagrante.
ITRM20010293A1 (it) * 2001-05-29 2002-11-29 Sigma Tau Ind Farmaceuti Uso della acetil-l-carnetina per la preparazione di un medicamento per la prevenzione del dolore.
ITRM20010445A1 (it) * 2001-07-25 2003-01-27 Sigma Tau Healthscience Spa Alfa-chetoglutarati di principi attivi e composizioni che li contengono.
ITRM20010729A1 (it) * 2001-12-12 2003-06-12 Aldo Fassi Sale di acetil l-carnitina con un acido organico dicarbossilico e procedimento per la sua preparazione.
ITRM20020055A1 (it) * 2002-02-04 2003-08-04 Aldo Fassi Sali metallici di carnitine, integratori dietetici/nutritivi che li contengono e kit dietetici per contrastare disturbi sessuali in soggetti
EP1901715B1 (en) * 2005-07-05 2012-05-02 Lonza AG Spray-drying process for producing a dry carnitine powder or granulate
JP4915723B2 (ja) * 2006-03-13 2012-04-11 コスモ石油株式会社 アミノ酸リン酸類塩の製造方法
JP5069416B2 (ja) * 2006-03-15 2012-11-07 サントリーホールディングス株式会社 吸湿性の改善された飲食品用組成物
US8019451B2 (en) * 2006-11-22 2011-09-13 Target Brands, Inc. Financial transaction product with media player
CN101209975B (zh) * 2006-12-29 2010-12-01 沈阳科硕营养科技有限公司 左旋肉碱富马酸钙及其制备方法与用途
KR100903549B1 (ko) * 2008-07-29 2009-06-23 주식회사 카이로제닉스 균질한 결정성의 아세틸-ｌ-카르니틴과 티옥트산 칼륨염의 복합염, 이의 제조방법 및 이를 포함하는 약학적 조성물
CN101817759B (zh) * 2010-05-12 2013-06-05 天津天成制药有限公司 L-肉碱硝酸盐的制备方法
PT3164125T (pt) 2014-07-03 2023-12-12 Silti Ag Métodos e composições para tratar obesidade, prevenir ganho de peso, promover perda de peso, promover emagrecimento ou tratar ou prevenir o desenvolvimento de diabetes
WO2017105090A1 (ko) * 2015-12-14 2017-06-22 제이투에이치바이오텍 (주) 오로트산 l-카르니틴의 결정질 다형체, 이의 제조방법 또는 용도
CN106045919B (zh) * 2016-07-07 2022-08-09 湖北楚维药业有限公司 一种左旋肉碱乳清酸盐的制备方法
CN106748845B (zh) * 2016-12-23 2018-11-20 东北制药集团股份有限公司 一种左旋肉碱盐微粉的制备方法
CN108383741A (zh) * 2018-03-16 2018-08-10 开原亨泰化工有限公司 一种制备左旋肉碱成盐的新方法
TWI710766B (zh) * 2018-08-13 2020-11-21 國立臺灣大學 使用口服肉鹼耐量試驗以測定一個體內氧化三甲胺產能之檢測方法
WO2025037993A1 (en) 2023-08-13 2025-02-20 Filip Majewski Dosage form for peptide agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1153640A (en) * 1967-04-10 1969-05-29 Soc D Etudes Prod Chimique A Carnitin Salt
FR2529545B1 (fr) * 1982-07-02 1985-05-31 Sanofi Sa Nouveaux sels de carnitine ainsi que leur procede de preparation

Also Published As

Publication number Publication date
EP0150688A1 (en) 1985-08-07
EP0150688B1 (en) 1987-04-22
DK164543C (da) 1992-12-07
US4602039A (en) 1986-07-22
ES8601856A1 (es) 1985-11-16
KR900003020B1 (ko) 1990-05-04
DK609984A (da) 1985-06-29
DE3463261D1 (en) 1987-05-27
CA1252098A (en) 1989-04-04
GR82612B (en) 1985-05-02
KR850004580A (ko) 1985-07-25
DK164543B (da) 1992-07-13
IE843233L (en) 1985-06-28
DK609984D0 (da) 1984-12-19
IE57942B1 (en) 1993-05-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050719