ES538191A0 - Un procedimiento para preparar un 2-bromo-6 b, 9a-difluoro-11b, 17a, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21-diester - Google Patents

Un procedimiento para preparar un 2-bromo-6 b, 9a-difluoro-11b, 17a, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21-diester

Info

Publication number: ES538191A0
Authority: ES; Spain
Prior art keywords: trihidroxi; brmo; pregnadien; diona; diester
Prior art date: 1982-06-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES538191A

Other languages

English (en)

Other versions

ES8507571A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

DIC Corp

Original Assignee

Dainippon Ink and Chemicals Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-06-21

Filing date

1984-11-30

Publication date

1985-09-01

1982-06-21 Priority claimed from JP10536782A external-priority patent/JPS58222100A/ja

1982-12-27 Priority claimed from JP22707782A external-priority patent/JPS58225099A/ja

1982-12-27 Priority claimed from JP22707682A external-priority patent/JPS58225100A/ja

1984-11-30 Application filed by Dainippon Ink and Chemicals Co Ltd filed Critical Dainippon Ink and Chemicals Co Ltd

1985-09-01 Publication of ES8507571A1 publication Critical patent/ES8507571A1/es

1985-09-01 Publication of ES538191A0 publication Critical patent/ES538191A0/es

Status Granted legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)

ES538191A 1982-06-21 1984-11-30 Un procedimiento para preparar un 2-bromo-6 b, 9a-difluoro-11b, 17a, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21-diester Granted ES538191A0 (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP10536782A JPS58222100A (ja)	1982-06-21	1982-06-21	ステロイド化合物の製造方法
JP22707782A JPS58225099A (ja)	1982-12-27	1982-12-27	ステロイド化合物およびその製造方法
JP22707682A JPS58225100A (ja)	1982-12-27	1982-12-27	ステロイド化合物およびその製造方法

Publications (2)

Publication Number	Publication Date
ES8507571A1 ES8507571A1 (es)	1985-09-01
ES538191A0 true ES538191A0 (es)	1985-09-01

Family

ID=27310464

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
ES523430A Expired ES8504842A1 (es)	1982-06-21	1983-06-20	Un procedimiento para preparar un 2-bromo-6b, 9x-difluoro-11n3, 17x, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21 diester
ES538191A Granted ES538191A0 (es)	1982-06-21	1984-11-30	Un procedimiento para preparar un 2-bromo-6 b, 9a-difluoro-11b, 17a, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21-diester
ES538192A Expired ES8507572A1 (es)	1982-06-21	1984-11-30	Un procedimiento para preparar un 2-bromo-6b-9a - difluoro-11b, 17a, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21-diester

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ES523430A Expired ES8504842A1 (es)	1982-06-21	1983-06-20	Un procedimiento para preparar un 2-bromo-6b, 9x-difluoro-11n3, 17x, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21 diester

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES538192A Expired ES8507572A1 (es)	1982-06-21	1984-11-30	Un procedimiento para preparar un 2-bromo-6b-9a - difluoro-11b, 17a, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21-diester

Country Status (4)

Country	Link
US (1)	US4525303A (es)
EP (1)	EP0097328B1 (es)
DE (1)	DE3373189D1 (es)
ES (3)	ES8504842A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5319115A (en) *	1987-08-25	1994-06-07	Cocensys Inc.	Method for making 3α-hydroxy, 3β-substituted-pregnanes
US4874855A (en) *	1987-11-04	1989-10-17	Dainippon Ink And Chemicals, Inc.	Steroid compounds and process of preparing the same
FR2691968B1 (fr) *	1992-06-04	1994-07-29	Roussel Uclaf	Nouveau procede de preparation d'un derive sterouide 11-ceto.
US5602248A (en) *	1995-03-16	1997-02-11	Schering Corporation	Process for preparation of 9α-chloro-11β-formyloxypregna-3,20-diones
US5670676A (en) *	1995-03-16	1997-09-23	Schering Corporation	Process for preparation of 9α -chloro-11β formyloxypregna-3.20-diones
NZ603107A (en)	2008-05-28	2014-03-28	Validus Biopharma Inc	Non-hormonal steroid modulators of nf-kb for treatment of disease
CN103509075A (zh) *	2012-06-29	2014-01-15	中国药科大学	一种制备二氟泼尼酯的方法
US10799514B2 (en)	2015-06-29	2020-10-13	Reveragen Biopharma, Inc.	Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
CN108373492B (zh) *	2018-04-20	2021-12-21	江苏远大仙乐药业有限公司	一种醋酸可的松的制备方法
US11382922B2 (en)	2019-03-07	2022-07-12	Reveragen Biopharma, Inc.	Aqueous oral pharmaceutical suspension compositions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2779775A (en) *	1954-09-30	1957-01-29	Merck & Co Inc	Phosphate derivatives of 9alpha-fluorosteroids
US2951840A (en) *	1957-07-20	1960-09-06	Syntex Sa	6-fluoro pregnanes and intermediates therefor
US3022295A (en) *	1959-11-02	1962-02-20	Pfizer & Co C	16beta-difluorinated corticosteroids and intermediates
US4272446A (en) *	1974-02-27	1981-06-09	Pierrel S.P.A.	Steroids and process for preparing the same
NL7502252A (nl) *	1974-02-27	1975-08-29	Pierrel Spa	Werkwijze voor het bereiden van een geneesmid- del met anti-inflammatoire werking, gevormd ge- neesmiddel verkregen volgens deze werkwijze alsmede werkwijze voor het bereiden van in het geneesmiddel gebruikte nieuwe steroiden.
US4189440A (en) *	1974-03-08	1980-02-19	Gaetano Palladino	2-Bromo-6β-fluoro-3-keto-Δ1,4 -steroids of the pregnane series
US4221786A (en) *	1978-06-20	1980-09-09	Ciba-Geigy Corporation	Novel halogenopregnadienes and process for the manufacture thereof
IT1193853B (it) *	1979-11-07	1988-08-31	Gaetano Palladino	Procedimento per la preparazione di derivati di steroidi e prodotti ottenuti
US4340538A (en) *	1980-07-21	1982-07-20	The Upjohn Company	Process for producing 6α-fluoro-Δ1,4 -3-keto steroids

1983
- 1983-06-15 DE DE8383105883T patent/DE3373189D1/de not_active Expired
- 1983-06-15 EP EP83105883A patent/EP0097328B1/en not_active Expired
- 1983-06-17 US US06/505,292 patent/US4525303A/en not_active Expired - Fee Related
- 1983-06-20 ES ES523430A patent/ES8504842A1/es not_active Expired
1984
- 1984-11-30 ES ES538191A patent/ES538191A0/es active Granted
- 1984-11-30 ES ES538192A patent/ES8507572A1/es not_active Expired

Also Published As

Publication number	Publication date
ES538192A0 (es)	1985-09-01
EP0097328A2 (en)	1984-01-04
ES523430A0 (es)	1985-04-16
ES8507571A1 (es)	1985-09-01
EP0097328A3 (en)	1984-05-30
DE3373189D1 (en)	1987-10-01
EP0097328B1 (en)	1987-08-26
US4525303A (en)	1985-06-25
ES8504842A1 (es)	1985-04-16
ES8507572A1 (es)	1985-09-01

Publication	Publication Date	Title
ES534202A0 (es)	1985-06-01	Un procedimiento para preparar nuevos compuestos de cefem.
ES523195A0 (es)	1984-10-01	Un procedimiento para preparar alquil-glicosidos
ES537668A0 (es)	1985-09-16	Un procedimiento para preparar n-formil-3-fenoxi-1-azetidincarboxamidas
ES522029A0 (es)	1984-07-16	Procedimiento para preparar un plasmido compuesto.
ES523064A0 (es)	1984-10-01	Procedimiento para preparar azetidinas.
ES513296A0 (es)	1983-08-01	Un procedimiento para preparar nuevos compuestos de cefem.
AR231308A1 (es)	1984-10-31	Un procedimiento para preparar 1-be-d-ribofuranosil-1,2,4-triazolcarboxamida rivavirina
ES519652A0 (es)	1984-03-16	Un procedimiento para obtener s-adenosil-metionina.
ES530391A0 (es)	1985-05-01	Un metodo para preparar derivados de 4-hidroxi-2-quinolona.
ES520364A0 (es)	1984-04-16	Un procedimiento para preparar compuestos de cefem.
ES517459A0 (es)	1983-12-16	Un procedimiento para preparar un dentifrico estable.
ES523193A0 (es)	1984-10-01	Un procedimiento para preparar 3-fenoxi-1-azetidincarbo-xznmidas
ES518758A0 (es)	1984-03-01	Un procedimiento para preparar azetidinas.
ES538191A0 (es)	1985-09-01	Un procedimiento para preparar un 2-bromo-6 b, 9a-difluoro-11b, 17a, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21-diester
ES531910A0 (es)	1985-06-01	Un procedimiento para preparar nuevas 5-acil-2-(1h)-piridinonas.
ES521813A0 (es)	1985-02-01	Procedimiento para preparar alcohil-polisacaridos.
ES520531A0 (es)	1984-05-16	Procedimiento para preparar tioeteres.
ES493798A0 (es)	1981-08-01	Un procedimiento para preparar 7-alcoxicarbonil-6,8-dime- til-4-hidroximetil-1-ftalazona
ES519936A0 (es)	1984-03-16	Un procedimiento para preparar derivados de pirimidona.
ES524772A0 (es)	1985-06-01	Un procedimiento para preparar fenilanilinas-n.sustituidas.
ES522716A0 (es)	1984-08-16	Un procedimiento para preparar un derivado de pirazol.
ES523277A0 (es)	1985-04-16	Un procedimiento para preparar peptidos.
ES527278A0 (es)	1985-04-16	Un procedimiento para obtener 2,5-anhidro-3,4,6-tri-o-acil-d-alonselenocarboxamida
ES526282A0 (es)	1985-04-16	Un procedimiento para preparar una b-lactama
ES520595A0 (es)	1984-10-01	Un procedimiento para preparar s-2-acetil-7-2,3-epoxipropoxi benzofurano.

Legal Events

Date	Code	Title	Description
1997-03-16	FD1A	Patent lapsed	Effective date: 19970203