ES500814A0 - Un procedimiento para la preparacion de nuevos derivados de 3-(1-piperidemil)alquil-4h-pirido(1,2-a)pirimidin-4-ona. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de 3-(1-piperidemil)alquil-4h-pirido(1,2-a)pirimidin-4-ona.Info
- Publication number
- ES500814A0 ES500814A0 ES500814A ES500814A ES500814A0 ES 500814 A0 ES500814 A0 ES 500814A0 ES 500814 A ES500814 A ES 500814A ES 500814 A ES500814 A ES 500814A ES 500814 A0 ES500814 A0 ES 500814A0
- Authority
- ES
- Spain
- Prior art keywords
- piperidemil
- pirido
- pirimidin
- ona
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13484580A | 1980-03-28 | 1980-03-28 | |
| US06/191,632 US4342870A (en) | 1980-03-28 | 1980-09-29 | Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES500814A0 true ES500814A0 (es) | 1982-11-01 |
| ES8300763A1 ES8300763A1 (es) | 1982-11-01 |
Family
ID=26832744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES500814A Expired ES8300763A1 (es) | 1980-03-28 | 1981-03-27 | Un procedimiento para la preparacion de nuevos derivados de 3-(1-piperidemil)alquil-4h-pirido(1,2-a)pirimidin-4-ona. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4342870A (es) |
| EP (1) | EP0037265B1 (es) |
| AU (1) | AU537700B2 (es) |
| BG (1) | BG36199A3 (es) |
| CA (1) | CA1163994A (es) |
| CS (1) | CS256366B2 (es) |
| DE (1) | DE3168433D1 (es) |
| DK (1) | DK159390C (es) |
| ES (1) | ES8300763A1 (es) |
| FI (1) | FI71737C (es) |
| GR (1) | GR72488B (es) |
| HU (1) | HU187329B (es) |
| IE (1) | IE51319B1 (es) |
| IL (1) | IL62494A (es) |
| MA (1) | MA19107A1 (es) |
| NO (1) | NO156752C (es) |
| NZ (1) | NZ196522A (es) |
| PH (1) | PH16530A (es) |
| PT (1) | PT72740B (es) |
| RO (1) | RO82508A (es) |
| SU (1) | SU1068037A3 (es) |
| YU (1) | YU43010B (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4443451A (en) | 1981-07-15 | 1984-04-17 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidin-5-one derivatives |
| US4548938A (en) * | 1981-07-15 | 1985-10-22 | Janssen Pharmaceutica N.V. | 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds |
| US4355037A (en) * | 1981-11-12 | 1982-10-19 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidyl)-1,2-benzisoxales |
| US4485107A (en) * | 1982-11-01 | 1984-11-27 | Janssen Pharmaceutica N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones |
| US4581171A (en) * | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4888426A (en) * | 1983-11-30 | 1989-12-19 | Janssen Pharmaceutica N.V. | 1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine |
| US4695569A (en) * | 1983-11-30 | 1987-09-22 | Janssen Pharmaceutica N.V. | Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines |
| PH23995A (en) * | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
| US4548939A (en) * | 1984-10-01 | 1985-10-22 | Janssen Pharmaceutica N. V. | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones |
| US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
| SG47757A1 (en) * | 1986-09-22 | 1998-04-17 | Janssen Pharmaceutica Nv | Serotonin antagonists for treating wounds |
| IL90879A0 (en) * | 1988-09-02 | 1990-02-09 | Janssen Pharmaceutica Nv | 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them |
| CA2000786C (en) * | 1988-11-07 | 1999-01-26 | Cornelus G. M. Janssen | 3-piperidinyl-1,2-benzisoxazoles |
| WO1990006303A1 (en) * | 1988-12-02 | 1990-06-14 | Pfizer Inc. | Arylpiperidine derivatives |
| JPH04504263A (ja) * | 1989-03-23 | 1992-07-30 | マリンクロッド・インコーポレイテッド | 放射性沃素又は臭素標識ピペリジン化合物、並びに上記化合物の及び上記化合物を含む組成物の製法 |
| DE4138756A1 (de) * | 1991-11-26 | 1993-05-27 | Troponwerke Gmbh & Co Kg | Kombination mit neuroprotektiver wirkung |
| US5266571A (en) * | 1992-01-09 | 1993-11-30 | Amer Moh Samir | Treatment of hemorrhoids with 5-HT2 antagonists |
| ES2163407T3 (es) * | 1992-02-13 | 2002-02-01 | Merrell Pharma Inc | Derivados piperidinilos tiaciclicos. |
| DE69330283T2 (de) * | 1992-07-13 | 2002-01-10 | Janssen Pharmaceutica N.V., Beerse | Neue 4-(3-benzofuranyl) piperidinyl und 4-(3-benzothienyl) piperidinyl-derivate und diese enthaltende pharmazeutische zusammenstellungen |
| PL314481A1 (en) | 1993-11-19 | 1996-09-16 | Janssen Pharmaceutica Nv | Microencapsulated substituted 3-piperidinyl 1,2-benzoisoxazoles and 1,2-benzoisothiazoles |
| ES2085234B1 (es) * | 1994-02-24 | 1997-01-16 | Vita Invest Sa | Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen. |
| TW421649B (en) * | 1995-01-31 | 2001-02-11 | Janssen Pharmaceutica Nv | 4-(1H-indol-1yl)-1-piperidinyl derivatives |
| US5753664A (en) * | 1995-03-16 | 1998-05-19 | Takeda Chemical Industries, Ltd. | Heterocyclic compounds, their production and use |
| CN100390146C (zh) * | 2002-11-13 | 2008-05-28 | 斯索恩有限公司 | 制备利培酮的方法和用于该方法的中间体 |
| WO2004094415A1 (en) * | 2003-04-22 | 2004-11-04 | Synthon B.V. | Risperidone monohydrochloride |
| DK3106166T3 (da) | 2008-02-29 | 2021-01-11 | Vm Therapeutics Llc | Forbindelser til behandling af smertesyndrom og andre lidelser |
| SG11201404713PA (en) * | 2012-02-10 | 2014-09-26 | Ptc Therapeutics Inc | Compounds for treating spinal muscular atrophy |
| MX352962B (es) | 2012-03-01 | 2017-12-15 | Ptc Therapeutics Inc | Compuestos para tratar atrofia muscular espinal. |
| KR102109992B1 (ko) | 2012-03-23 | 2020-05-13 | 피티씨 테라퓨틱스, 인크. | 척수성 근위축증을 치료하기 위한 화합물 |
| WO2014143915A1 (en) * | 2013-03-15 | 2014-09-18 | Vm Therapeutics Llc | Novel crystalline forms |
| US10195202B2 (en) | 2013-12-19 | 2019-02-05 | Ptc Therapeutics, Inc. | Methods for modulating the amount of RNA transcripts |
| WO2016196386A1 (en) | 2015-05-30 | 2016-12-08 | Ptc Therapeutics, Inc. | Methods for modulating rna splicing |
| HUE055031T2 (hu) | 2015-12-10 | 2021-10-28 | Ptc Therapeutics Inc | Módszerek Huntington-kór kezelésére |
| AU2017363369A1 (en) | 2016-11-28 | 2019-05-30 | Ptc Therapeutics, Inc | Methods for modulating RNA splicing |
| JP7376471B2 (ja) | 2017-06-05 | 2023-11-08 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
| WO2018232039A1 (en) | 2017-06-14 | 2018-12-20 | Ptc Therapeutics, Inc. | Methods for modifying rna splicing |
| WO2019005993A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | METHODS OF TREATING HUNTINGTON'S DISEASE |
| CN111182898B (zh) | 2017-06-28 | 2024-04-16 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| CN112135815A (zh) | 2018-03-27 | 2020-12-25 | Ptc医疗公司 | 用于治疗亨廷顿氏病的化合物 |
| ES2983003T3 (es) | 2018-06-27 | 2024-10-21 | Ptc Therapeutics Inc | Compuestos heterocíclicos y heteroarílicos para el tratamiento de la enfermedad de Huntington |
| MX2020014315A (es) | 2018-06-27 | 2021-05-27 | Ptc Therapeutics Inc | Compuestos de heteroarilo para tratar la enfermedad de huntington. |
| US11685746B2 (en) | 2018-06-27 | 2023-06-27 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating Huntington's disease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3412094A (en) * | 1967-06-21 | 1968-11-19 | Searle & Co | 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners |
| US3960863A (en) * | 1974-06-25 | 1976-06-01 | Sankyo Company Limited | Pyrido[1,2-a]pyrimidinone derivatives |
| JPS5146497A (en) * | 1974-10-19 | 1976-04-20 | Masato Aiura | Hobuban |
| JPS525795A (en) * | 1975-06-28 | 1977-01-17 | Sankyo Co Ltd | Preparation of tetrahydro pyridopyrimidinone derivatives |
| HU173438B (hu) * | 1975-11-27 | 1979-05-28 | Chinoin Gyogyszer Es Vegyeszet | Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom |
-
1980
- 1980-09-29 US US06/191,632 patent/US4342870A/en not_active Expired - Lifetime
-
1981
- 1981-03-03 GR GR64291A patent/GR72488B/el unknown
- 1981-03-04 CA CA000372258A patent/CA1163994A/en not_active Expired
- 1981-03-17 NZ NZ196522A patent/NZ196522A/en unknown
- 1981-03-17 AU AU68429/81A patent/AU537700B2/en not_active Ceased
- 1981-03-21 MA MA19313A patent/MA19107A1/fr unknown
- 1981-03-24 SU SU813261927A patent/SU1068037A3/ru active
- 1981-03-24 CS CS812134A patent/CS256366B2/cs unknown
- 1981-03-26 IL IL62494A patent/IL62494A/xx unknown
- 1981-03-26 PT PT72740A patent/PT72740B/pt not_active IP Right Cessation
- 1981-03-26 PH PH25429A patent/PH16530A/en unknown
- 1981-03-26 DK DK138281A patent/DK159390C/da not_active IP Right Cessation
- 1981-03-27 EP EP81301335A patent/EP0037265B1/en not_active Expired
- 1981-03-27 FI FI810956A patent/FI71737C/fi not_active IP Right Cessation
- 1981-03-27 IE IE706/81A patent/IE51319B1/en not_active IP Right Cessation
- 1981-03-27 ES ES500814A patent/ES8300763A1/es not_active Expired
- 1981-03-27 NO NO811058A patent/NO156752C/no unknown
- 1981-03-27 BG BG051433A patent/BG36199A3/xx unknown
- 1981-03-27 HU HU81783A patent/HU187329B/hu not_active IP Right Cessation
- 1981-03-27 DE DE8181301335T patent/DE3168433D1/de not_active Expired
- 1981-03-27 YU YU810/81A patent/YU43010B/xx unknown
- 1981-03-28 RO RO81103848A patent/RO82508A/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO156752C (no) | 1987-11-18 |
| EP0037265B1 (en) | 1985-01-23 |
| DK138281A (da) | 1981-09-29 |
| IE810706L (en) | 1981-09-28 |
| DK159390B (da) | 1990-10-08 |
| FI71737C (fi) | 1987-02-09 |
| YU43010B (en) | 1989-02-28 |
| MA19107A1 (fr) | 1981-10-01 |
| ES8300763A1 (es) | 1982-11-01 |
| PT72740B (en) | 1982-11-16 |
| HU187329B (en) | 1985-12-28 |
| BG36199A3 (en) | 1984-09-14 |
| RO82508A (ro) | 1983-09-26 |
| AU6842981A (en) | 1981-10-01 |
| NO156752B (no) | 1987-08-10 |
| IE51319B1 (en) | 1986-12-10 |
| NZ196522A (en) | 1985-10-11 |
| AU537700B2 (en) | 1984-07-05 |
| IL62494A0 (en) | 1981-05-20 |
| CA1163994A (en) | 1984-03-20 |
| RO82508B (ro) | 1983-08-30 |
| PH16530A (en) | 1983-11-10 |
| NO811058L (no) | 1981-09-29 |
| DE3168433D1 (de) | 1985-03-07 |
| FI810956L (fi) | 1981-09-29 |
| CS256366B2 (en) | 1988-04-15 |
| GR72488B (es) | 1983-11-14 |
| EP0037265A1 (en) | 1981-10-07 |
| US4342870A (en) | 1982-08-03 |
| DK159390C (da) | 1991-03-04 |
| SU1068037A3 (ru) | 1984-01-15 |
| FI71737B (fi) | 1986-10-31 |
| PT72740A (en) | 1981-04-01 |
| YU81081A (en) | 1983-12-31 |
| IL62494A (en) | 1984-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970519 |