ES506237A0 - Procedimiento para la obtencion de derivados n-sustituidos de la 1-desoxijirimicina - Google Patents
Procedimiento para la obtencion de derivados n-sustituidos de la 1-desoxijirimicinaInfo
- Publication number
- ES506237A0 ES506237A0 ES506237A ES506237A ES506237A0 ES 506237 A0 ES506237 A0 ES 506237A0 ES 506237 A ES506237 A ES 506237A ES 506237 A ES506237 A ES 506237A ES 506237 A0 ES506237 A0 ES 506237A0
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- aminosorbose
- give
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 5
- KULQACNMKIDJNN-GASJEMHNSA-N (2r,3s,4r,5r)-1-aminohexane-1,2,3,4,5,6-hexol Chemical compound NC(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO KULQACNMKIDJNN-GASJEMHNSA-N 0.000 abstract 2
- APMMRUCUTJHHLZ-AMVSKUEXSA-N (3r,4s,5s)-6-amino-1,3,4,5,6-pentahydroxyhexan-2-one Chemical compound NC(O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)CO APMMRUCUTJHHLZ-AMVSKUEXSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002906 microbiologic effect Effects 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 150000008494 α-glucosides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Gas Separation By Absorption (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803038901 DE3038901A1 (de) | 1980-10-15 | 1980-10-15 | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8206475A1 ES8206475A1 (es) | 1982-08-16 |
| ES506237A0 true ES506237A0 (es) | 1982-08-16 |
Family
ID=6114418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES506237A Granted ES506237A0 (es) | 1980-10-15 | 1981-10-14 | Procedimiento para la obtencion de derivados n-sustituidos de la 1-desoxijirimicina |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4405714A (es) |
| EP (1) | EP0049858B1 (es) |
| JP (1) | JPS5798261A (es) |
| AT (1) | ATE11913T1 (es) |
| CA (1) | CA1174996A (es) |
| DE (2) | DE3038901A1 (es) |
| ES (1) | ES506237A0 (es) |
| FI (1) | FI78469C (es) |
| HU (1) | HU188700B (es) |
| IL (1) | IL64034A (es) |
| ZA (1) | ZA817084B (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3507019A1 (de) * | 1985-02-28 | 1986-08-28 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung |
| DE3611841A1 (de) * | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
| US4999360A (en) * | 1987-12-21 | 1991-03-12 | Monsanto Company | Method of inhibiting virus |
| EP0344383A1 (en) * | 1988-06-02 | 1989-12-06 | Merrell Dow Pharmaceuticals Inc. | Novel alpha-Glucosidase inhibitors |
| US5329025A (en) * | 1988-09-21 | 1994-07-12 | G. D. Searle & Co. | 3-azido compound |
| DE3936295A1 (de) * | 1989-11-01 | 1991-05-02 | Bayer Ag | Verfahren zur herstellung von zwischenprodukten und zur synthese von n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine |
| US5252587A (en) * | 1990-04-27 | 1993-10-12 | Merrell Dow Pharmaceuticals, Inc. | N-derivatives of 1-deoxy nojirimycin |
| US5536732A (en) * | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
| US5151519A (en) * | 1990-05-07 | 1992-09-29 | G. D. Searle & Co. | Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof |
| US5504078A (en) * | 1990-06-08 | 1996-04-02 | Merrell Dow Pharmaceuticals Inc. | α-glucosidase inhibitors |
| DK0477160T3 (da) * | 1990-09-20 | 1996-05-20 | Monsanto Co | Fremgangsmåde til fremstilling af N-substitueret 1-deoxynojirimycin |
| DE4030040A1 (de) * | 1990-09-22 | 1992-03-26 | Bayer Ag | Enzymatische de-acylierung von acyl-aminosorbosen und dessen verwendung bei der herstellung von 1-desoxynojirimicin |
| US5401645A (en) * | 1992-03-16 | 1995-03-28 | Monsanto Company | Process for producing n-substituted polyhydroxy nitrogen-containing heterocycles utilizing acetobacteraceae and corynebacterium |
| WO1995022975A1 (en) * | 1994-02-25 | 1995-08-31 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
| DE19741235A1 (de) | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
| US20050032841A1 (en) * | 1999-04-20 | 2005-02-10 | Steven Walkley | Therapeutic compositions and methods of treating glycolipid storage related disorders |
| GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
| US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
| DE60037664T2 (de) * | 1999-08-10 | 2008-12-24 | The Chancellor, Masters And Scholars Of The University Of Oxford | Langkettige n-alkyl verbindungen und deren oxa-derivate zur verwendung als anitvirale mittel |
| DK1379676T3 (da) * | 2001-03-19 | 2006-09-18 | Lonza Ag | Fremgangsmåde til fremstilling af 2-hydroxymethylpyrrolidin-3,4-dioler |
| CA2612538C (en) | 2005-05-17 | 2015-06-30 | Amicus Therapeutics, Inc. | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
| CN1328270C (zh) * | 2005-09-26 | 2007-07-25 | 鲁南制药集团股份有限公司 | 一种工业化生产米格列醇的方法 |
| GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| WO2008088581A2 (en) | 2006-08-02 | 2008-07-24 | United Therapeutics Corporation | Liposome treatment of viral infections |
| JP2010510171A (ja) * | 2006-08-21 | 2010-04-02 | ユナイテッド セラピューティクス コーポレーション | ウイルス感染症の治療のための併用療法 |
| CN101289418B (zh) * | 2007-04-19 | 2011-02-02 | 浙江医药股份有限公司新昌制药厂 | 米格列醇晶体及其制备方法 |
| US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
| EP2282723A2 (en) * | 2008-03-26 | 2011-02-16 | University of Oxford | Endoplasmic reticulum targeting liposomes |
| US8450345B2 (en) | 2009-02-23 | 2013-05-28 | The Chancellor, Masters And Scholars Of The University Of Oxford | Iminosugars and methods of treating viral diseases |
| JP5951996B2 (ja) * | 2009-02-24 | 2016-07-13 | ユナイテッド セラピューティクス コーポレーション | イミノ糖及びアレナウイルス感染症を治療する方法 |
| CA2757026A1 (en) * | 2009-03-27 | 2010-09-30 | The Chancellor, Masters And Scholars Of The University Of Oxford | Cholesterol level lowering liposomes |
| JP5634510B2 (ja) | 2009-06-12 | 2014-12-03 | ユナイテッド セラピューティクス コーポレイション | イミノ糖ならびにブニヤウイルスおよびトガウイルス疾患を治療する方法 |
| JP5575246B2 (ja) * | 2009-09-04 | 2014-08-20 | ユナイテッド セラピューティクス コーポレイション | ポックスウイルス感染の治療方法 |
| EP2473046B1 (en) | 2009-09-04 | 2014-10-22 | United Therapeutics Corporation | Iminosugars for their use in the treatment of filoviral diseases |
| ES2466027T3 (es) * | 2009-09-04 | 2014-06-09 | United Therapeutics Corporation | Procedimiento para el tratamiento de infecciones por ortomixovirus |
| CN102740852A (zh) | 2009-12-07 | 2012-10-17 | 牛津大学之校长及学者 | 用于抑制破骨细胞形成和/或破骨细胞活化的n-取代的脱氧野尻霉素化合物 |
| CN104698749B (zh) * | 2010-01-25 | 2019-11-19 | 罗门哈斯电子材料有限公司 | 包含含氮化合物的光致抗蚀剂 |
| SG11201601646YA (en) | 2013-09-16 | 2016-04-28 | Emergent Virology Llc | Deoxynojirimycin derivatives and methods of their using |
| BR112017008898B1 (pt) | 2014-11-05 | 2022-11-29 | Emergent Virology Llc | Compostos de iminoaçúcares, suas composições farmacêuticas e usos dos mesmos para tratar doenças virais |
| EP3318277A1 (en) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases |
| CN114516831B (zh) * | 2022-01-21 | 2024-03-08 | 浙江奥翔药业股份有限公司 | 一种米格列醇的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2658563A1 (de) * | 1976-12-23 | 1978-06-29 | Bayer Ag | Inhibitoren fuer glykosid-hydrolasen aus bacillen |
| NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| GB2009152B (en) * | 1977-11-10 | 1982-01-06 | Nippon Shinyaku Co Ltd | Method for producing moranoline and n-methylmoranoline |
| DE2830469A1 (de) * | 1978-07-11 | 1980-01-24 | Bayer Ag | Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten |
| DE2834122A1 (de) * | 1978-08-03 | 1980-02-14 | Bayer Ag | Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose |
| DE2839309A1 (de) * | 1978-09-09 | 1980-03-27 | Bayer Ag | 3,4,5-trihydroxypiperidin-derivate |
| DE2853573A1 (de) * | 1978-12-12 | 1980-07-03 | Bayer Ag | Herstellung von n-substituierten derivaten des l-desoxynojirimycins |
-
1980
- 1980-10-15 DE DE19803038901 patent/DE3038901A1/de not_active Withdrawn
-
1981
- 1981-09-25 US US06/305,656 patent/US4405714A/en not_active Expired - Lifetime
- 1981-10-07 EP EP81108007A patent/EP0049858B1/de not_active Expired
- 1981-10-07 AT AT81108007T patent/ATE11913T1/de not_active IP Right Cessation
- 1981-10-07 DE DE8181108007T patent/DE3169076D1/de not_active Expired
- 1981-10-12 IL IL64034A patent/IL64034A/xx not_active IP Right Cessation
- 1981-10-13 CA CA000387752A patent/CA1174996A/en not_active Expired
- 1981-10-13 FI FI813182A patent/FI78469C/fi not_active IP Right Cessation
- 1981-10-13 JP JP56162120A patent/JPS5798261A/ja active Granted
- 1981-10-14 ZA ZA817084A patent/ZA817084B/xx unknown
- 1981-10-14 ES ES506237A patent/ES506237A0/es active Granted
- 1981-10-14 HU HU812966A patent/HU188700B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES8206475A1 (es) | 1982-08-16 |
| DE3169076D1 (en) | 1985-03-28 |
| JPS5798261A (en) | 1982-06-18 |
| FI78469C (fi) | 1989-08-10 |
| IL64034A0 (en) | 1982-01-31 |
| FI813182L (fi) | 1982-04-16 |
| DE3038901A1 (de) | 1982-05-06 |
| US4405714A (en) | 1983-09-20 |
| CA1174996A (en) | 1984-09-25 |
| HU188700B (en) | 1986-05-28 |
| FI78469B (fi) | 1989-04-28 |
| JPH039108B2 (es) | 1991-02-07 |
| EP0049858A2 (de) | 1982-04-21 |
| ATE11913T1 (de) | 1985-03-15 |
| IL64034A (en) | 1986-03-31 |
| EP0049858B1 (de) | 1985-02-20 |
| EP0049858A3 (en) | 1982-10-13 |
| ZA817084B (en) | 1982-09-29 |
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