ES493011A0 - Procedimiento para la preparacion de derivados de pirimi- do-(6,1-a)-isoquinolein-4-onas - Google Patents
Procedimiento para la preparacion de derivados de pirimi- do-(6,1-a)-isoquinolein-4-onasInfo
- Publication number
- ES493011A0 ES493011A0 ES493011A ES493011A ES493011A0 ES 493011 A0 ES493011 A0 ES 493011A0 ES 493011 A ES493011 A ES 493011A ES 493011 A ES493011 A ES 493011A ES 493011 A0 ES493011 A0 ES 493011A0
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pirimido
- isoquinolein
- onas
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000543 intermediate Substances 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- CIVQDIGHVMGTPD-UHFFFAOYSA-N pyrimido[6,1-a]isoquinolin-4-one Chemical class C1=CC=C2C=CN3C(=O)N=CC=C3C2=C1 CIVQDIGHVMGTPD-UHFFFAOYSA-N 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782847693 DE2847693A1 (de) | 1978-11-03 | 1978-11-03 | Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8103083A1 ES8103083A1 (es) | 1981-02-16 |
| ES493011A0 true ES493011A0 (es) | 1981-02-16 |
Family
ID=6053766
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES485489A Granted ES485489A0 (es) | 1978-11-03 | 1979-10-29 | Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas |
| ES493011A Granted ES493011A0 (es) | 1978-11-03 | 1980-07-01 | Procedimiento para la preparacion de derivados de pirimi- do-(6,1-a)-isoquinolein-4-onas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES485489A Granted ES485489A0 (es) | 1978-11-03 | 1979-10-29 | Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4400506A (es) |
| EP (1) | EP0010759B1 (es) |
| JP (1) | JPS5564587A (es) |
| AT (1) | ATE21104T1 (es) |
| AU (1) | AU538039B2 (es) |
| CA (1) | CA1123434A (es) |
| DE (2) | DE2847693A1 (es) |
| DK (1) | DK465879A (es) |
| ES (2) | ES485489A0 (es) |
| FI (1) | FI66865C (es) |
| GR (1) | GR74082B (es) |
| HU (1) | HU181884B (es) |
| IL (1) | IL58609A0 (es) |
| NO (1) | NO793537L (es) |
| NZ (1) | NZ191994A (es) |
| PH (1) | PH15281A (es) |
| PT (1) | PT70401A (es) |
| ZA (1) | ZA795888B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI64370C (fi) * | 1977-05-05 | 1983-11-10 | Hoechst Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat |
| DE2847693A1 (de) | 1978-11-03 | 1980-05-22 | Hoechst Ag | Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen |
| FR2470130A2 (fr) * | 1979-11-21 | 1981-05-29 | Hoechst Ag | Derives de pyrimido (6,1-a) isoquinoleine-4-one, leur procede de preparation et leur application en therapeutique |
| DE3126837A1 (de) * | 1981-07-08 | 1983-01-27 | Hoechst Ag, 6000 Frankfurt | Triazino-(2,1-a)isochinolinderivate |
| DE3135831A1 (de) * | 1981-09-10 | 1983-04-28 | Hoechst Ag, 6230 Frankfurt | 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4612376A (en) * | 1983-03-25 | 1986-09-16 | Fujisawa Pharmaceutical Co., Ltd. | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent |
| ZW6284A1 (en) * | 1983-05-05 | 1985-10-30 | Hoffmann La Roche | Novel pyrimidone derivatives |
| MXPA01009846A (es) * | 1999-03-31 | 2003-06-24 | Vernalis Ltd | Derivados de pirimido (6, 1 - a) isoquinolin -4-ona. |
| EP1671651B1 (en) * | 1999-08-21 | 2009-11-11 | Nycomed GmbH | Synergistic combination of pumafentrine and salmeterol |
| TWI347845B (en) * | 2002-03-06 | 2011-09-01 | Nycomed Gmbh | Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA2688161C (en) | 2007-06-04 | 2020-10-20 | Kunwar Shailubhai | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| DK2681236T3 (en) | 2011-03-01 | 2018-04-16 | Synergy Pharmaceuticals Inc | PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS |
| CA2902348C (en) | 2013-02-25 | 2021-11-30 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| HK1220611A1 (zh) | 2013-03-15 | 2017-05-12 | Bausch Health Ireland Limited | 用於治疗胃肠道病症的组成物 |
| WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| CN113388007A (zh) | 2013-06-05 | 2021-09-14 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
| BR112016002789A2 (pt) | 2013-08-09 | 2017-11-21 | Ardelyx Inc | compostos e métodos para inibir transporte de fosfato |
| GB201613054D0 (en) | 2016-07-28 | 2016-09-14 | Verona Pharma Plc | New compound and process |
| WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
| GB202202297D0 (en) | 2022-02-21 | 2022-04-06 | Verona Pharma Plc | Formulation production process |
| AU2024309346A1 (en) | 2023-06-26 | 2026-01-08 | Verona Pharma Plc | Particulate composition comprising ensifetrine |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE590405A (es) * | 1959-05-02 | |||
| US3081306A (en) * | 1959-11-04 | 1963-03-12 | Pfizer & Co C | 2, 4-dioxo-3-aralkylaza-9, 10-di(lower alkoxy)-1, 2, 3, 4, 6, 7-hexahydro-11b-h-benzopyridocolines |
| GB1062357A (en) * | 1965-03-23 | 1967-03-22 | Pfizer & Co C | Quinazolone derivatives |
| US3476755A (en) * | 1967-01-17 | 1969-11-04 | Edward C Taylor | 8,13-diazasteroids |
| US3594379A (en) * | 1968-09-16 | 1971-07-20 | Sandoz Ag | 2,3-dihydroimidazo(1,2-c)quinazolines |
| US3876788A (en) * | 1970-08-27 | 1975-04-08 | Burroughs Wellcome Co | Heterocyclic compounds in the treatment of inflammatory of arthritic conditions |
| DE2720085A1 (de) * | 1977-05-05 | 1978-11-16 | Hoechst Ag | Pyrimido(6,1-a)isochinolin-2-on- derivate |
| IN147624B (es) | 1976-12-10 | 1980-05-03 | Hoechst Pharma | |
| FI64370C (fi) * | 1977-05-05 | 1983-11-10 | Hoechst Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat |
| DE2847693A1 (de) | 1978-11-03 | 1980-05-22 | Hoechst Ag | Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen |
-
1978
- 1978-11-03 DE DE19782847693 patent/DE2847693A1/de not_active Withdrawn
-
1979
- 1979-10-29 ES ES485489A patent/ES485489A0/es active Granted
- 1979-10-31 EP EP79104238A patent/EP0010759B1/de not_active Expired
- 1979-10-31 AT AT79104238T patent/ATE21104T1/de not_active IP Right Cessation
- 1979-10-31 DE DE7979104238T patent/DE2967610D1/de not_active Expired
- 1979-11-01 GR GR60383A patent/GR74082B/el unknown
- 1979-11-01 JP JP14053279A patent/JPS5564587A/ja active Pending
- 1979-11-01 NZ NZ191994A patent/NZ191994A/xx unknown
- 1979-11-01 FI FI793430A patent/FI66865C/fi not_active IP Right Cessation
- 1979-11-01 IL IL58609A patent/IL58609A0/xx unknown
- 1979-11-02 AU AU52453/79A patent/AU538039B2/en not_active Ceased
- 1979-11-02 HU HU79HO2195A patent/HU181884B/hu unknown
- 1979-11-02 ZA ZA00795888A patent/ZA795888B/xx unknown
- 1979-11-02 PT PT70401A patent/PT70401A/pt unknown
- 1979-11-02 CA CA339,089A patent/CA1123434A/en not_active Expired
- 1979-11-02 DK DK465879A patent/DK465879A/da not_active Application Discontinuation
- 1979-11-02 NO NO793537A patent/NO793537L/no unknown
- 1979-11-05 PH PH23245A patent/PH15281A/en unknown
-
1980
- 1980-07-01 ES ES493011A patent/ES493011A0/es active Granted
-
1981
- 1981-10-26 US US06/314,994 patent/US4400506A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ191994A (en) | 1982-09-07 |
| GR74082B (es) | 1984-06-06 |
| HU181884B (en) | 1983-11-28 |
| FI66865B (fi) | 1984-08-31 |
| CA1123434A (en) | 1982-05-11 |
| JPS5564587A (en) | 1980-05-15 |
| EP0010759B1 (de) | 1986-07-30 |
| US4400506A (en) | 1983-08-23 |
| ES8102125A1 (es) | 1980-12-16 |
| ES8103083A1 (es) | 1981-02-16 |
| PH15281A (en) | 1982-11-02 |
| PT70401A (de) | 1979-12-01 |
| FI66865C (fi) | 1984-12-10 |
| DE2967610D1 (en) | 1986-09-04 |
| NO793537L (no) | 1980-05-06 |
| EP0010759A2 (de) | 1980-05-14 |
| IL58609A0 (en) | 1980-02-29 |
| AU5245379A (en) | 1980-05-08 |
| DE2847693A1 (de) | 1980-05-22 |
| FI793430A7 (fi) | 1980-05-04 |
| ES485489A0 (es) | 1980-12-16 |
| ATE21104T1 (de) | 1986-08-15 |
| ZA795888B (en) | 1980-10-29 |
| EP0010759A3 (en) | 1981-08-19 |
| DK465879A (da) | 1980-05-04 |
| AU538039B2 (en) | 1984-07-26 |
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