ES481754A3 - Procedure for the preparation of silicine acid hemisuccinates. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of silicine acid hemisuccinates. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES481754A3 ES481754A3 ES481754A ES481754A ES481754A3 ES 481754 A3 ES481754 A3 ES 481754A3 ES 481754 A ES481754 A ES 481754A ES 481754 A ES481754 A ES 481754A ES 481754 A3 ES481754 A3 ES 481754A3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- hemisuccinates
- translation
- preparation
- machine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- DPBYCORQBMMFJZ-UHFFFAOYSA-N 20-episilicine Natural products O=C1CC2C(CC)CN(C)CC2CC2=C1NC1=CC=CC=C21 DPBYCORQBMMFJZ-UHFFFAOYSA-N 0.000 title 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 150000007529 inorganic bases Chemical class 0.000 abstract 2
- 150000007530 organic bases Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FDQAOULAVFHKBX-UHFFFAOYSA-N Isosilybin A Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC(=CC=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 FDQAOULAVFHKBX-UHFFFAOYSA-N 0.000 abstract 1
- SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 abstract 1
- VLGROHBNWZUINI-UHFFFAOYSA-N Silybin Natural products COc1cc(ccc1O)C2OC3C=C(C=CC3OC2CO)C4Oc5cc(O)cc(O)c5C(=O)C4O VLGROHBNWZUINI-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 abstract 1
- 229940043175 silybin Drugs 0.000 abstract 1
- 235000014899 silybin Nutrition 0.000 abstract 1
- 239000001384 succinic acid Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Process for the preparation of silybin-acid hemisuccinates, containing essentially 1 and/or 2 molecules of succinic acid per mole, as well as their salts with pharmacologically acceptable inorganic or organic bases, characterized in that it comprises reacting at temperatures between 0º and 100º c, equivalent of silybin with 1 to 3 equivalents of succinic acid, in the presence of a tertiary organic amine, preferably in pyridine, and treating the reaction product with an acid or optionally an inorganic acid chloride, releasing the silybinine hemisuccinate which, subsequently, it is transformed into the corresponding salt by reaction with pharmacologically acceptable organic or inorganic bases, which are purified chromatographically. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES481754A ES481754A3 (en) | 1979-06-21 | 1979-06-21 | Procedure for the preparation of silicine acid hemisuccinates. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES481754A ES481754A3 (en) | 1979-06-21 | 1979-06-21 | Procedure for the preparation of silicine acid hemisuccinates. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES481754A3 true ES481754A3 (en) | 1980-03-01 |
Family
ID=8478503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES481754A Expired ES481754A3 (en) | 1979-06-21 | 1979-06-21 | Procedure for the preparation of silicine acid hemisuccinates. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES481754A3 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103113359A (en) * | 2013-02-22 | 2013-05-22 | 西安安健药业有限公司 | Silibinin diunsymsuccinate and pharmaceutical salt thereof |
| CN103172622A (en) * | 2013-02-22 | 2013-06-26 | 西安安健药业有限公司 | Active isomer of silibinin di-succinate |
| CN103193768A (en) * | 2013-02-22 | 2013-07-10 | 西安安健药业有限公司 | Silybin dihemisuccinate isomer used for treatment of liver diseases |
-
1979
- 1979-06-21 ES ES481754A patent/ES481754A3/en not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103113359A (en) * | 2013-02-22 | 2013-05-22 | 西安安健药业有限公司 | Silibinin diunsymsuccinate and pharmaceutical salt thereof |
| CN103172622A (en) * | 2013-02-22 | 2013-06-26 | 西安安健药业有限公司 | Active isomer of silibinin di-succinate |
| CN103193768A (en) * | 2013-02-22 | 2013-07-10 | 西安安健药业有限公司 | Silybin dihemisuccinate isomer used for treatment of liver diseases |
| CN103172622B (en) * | 2013-02-22 | 2015-11-04 | 西安安健药业有限公司 | The active isomer of silybin bis-bias succinate |
| CN103113359B (en) * | 2013-02-22 | 2016-01-06 | 西安安健药业有限公司 | Silybin bis-bias succinate and pharmaceutical salts thereof |
| CN103193768B (en) * | 2013-02-22 | 2016-03-30 | 西安安健药业有限公司 | The silybin bis-bias succinate isomer for the treatment of hepatopathy |
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