[go: up one dir, main page]

ES480114A1 - Procedimiento para la preparacion de derivados de imidazoli-dina. - Google Patents

Procedimiento para la preparacion de derivados de imidazoli-dina.

Info

Publication number
ES480114A1
ES480114A1 ES480114A ES480114A ES480114A1 ES 480114 A1 ES480114 A1 ES 480114A1 ES 480114 A ES480114 A ES 480114A ES 480114 A ES480114 A ES 480114A ES 480114 A1 ES480114 A1 ES 480114A1
Authority
ES
Spain
Prior art keywords
preparation
intermediates
pharmaceutical compositions
active compounds
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES480114A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH546578A external-priority patent/CH642944A5/de
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES480114A1 publication Critical patent/ES480114A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de derivados de imidazolidina, de la fórmula general **(fórmula-01)** en donde R representa uno de los grupos **(fórmula-02)** caracterizado porque comprende hacer reaccionar un compuesto de la fórmula general **(formula-03)** en donde R tiene el significado antes indicado, bajo condiciones anhidras con alfa-amino- isobutironitrilo.
ES480114A 1977-10-28 1979-04-30 Procedimiento para la preparacion de derivados de imidazoli-dina. Expired ES480114A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
LU78407 1977-10-28
CH546578A CH642944A5 (en) 1978-05-19 1978-05-19 Urea derivatives
CH936778 1978-09-06

Publications (1)

Publication Number Publication Date
ES480114A1 true ES480114A1 (es) 1980-04-01

Family

ID=27175218

Family Applications (3)

Application Number Title Priority Date Filing Date
ES474592A Expired ES474592A1 (es) 1977-10-28 1978-10-27 Procedimiento para la preparacion de derivados de imidazoli-nina
ES480109A Expired ES480109A1 (es) 1977-10-28 1979-04-30 Procedimkiento para la preparacion de derivados de imidazo- lidina.
ES480114A Expired ES480114A1 (es) 1977-10-28 1979-04-30 Procedimiento para la preparacion de derivados de imidazoli-dina.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES474592A Expired ES474592A1 (es) 1977-10-28 1978-10-27 Procedimiento para la preparacion de derivados de imidazoli-nina
ES480109A Expired ES480109A1 (es) 1977-10-28 1979-04-30 Procedimkiento para la preparacion de derivados de imidazo- lidina.

Country Status (26)

Country Link
US (2) US4407814A (es)
EP (1) EP0001813B1 (es)
JP (1) JPS5470271A (es)
AR (2) AR219560A1 (es)
AT (2) AT366374B (es)
AU (1) AU522536B2 (es)
BR (1) BR7807097A (es)
CA (1) CA1107744A (es)
CU (1) CU34980A (es)
DE (2) DE2846946A1 (es)
DK (1) DK481678A (es)
ES (3) ES474592A1 (es)
FI (1) FI68618C (es)
FR (1) FR2422643A1 (es)
GB (1) GB2008102B (es)
GR (1) GR70681B (es)
IE (1) IE47962B1 (es)
IL (1) IL55773A (es)
IT (1) IT1099450B (es)
MC (1) MC1220A1 (es)
NL (1) NL7810563A (es)
NO (1) NO151461C (es)
NZ (1) NZ188721A (es)
PH (1) PH13569A (es)
PT (1) PT68705A (es)
SE (1) SE7811194L (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI801184A7 (fi) * 1979-04-24 1981-01-01 F Hoffmann La Roche & Co Menetelmä imidatsolidiini-johdannaisten valmistamiseksi.
DE2933917A1 (de) * 1979-08-22 1981-03-26 Basf Ag, 67063 Ludwigshafen 5-imino-imidazolidin-2-one und diese enthaltende herbizide.
DE3134933A1 (de) * 1981-09-03 1983-03-31 Hoechst Ag, 6230 Frankfurt "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung"
DE3382406D1 (de) * 1982-04-08 1991-10-17 Shell Int Research Neue hydantoine, ihre herstellung und verwendung.
US5112983A (en) * 1987-09-28 1992-05-12 Olin Corporation Process for producing 1,2,4-triazol-5-one using organic sulfonic acids and polymers thereof as a catalyst
USRE35956E (en) * 1991-01-09 1998-11-10 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2671348B1 (fr) * 1991-01-09 1993-03-26 Roussel Uclaf Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
FR2693461B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2715402B1 (fr) * 1994-01-05 1996-10-04 Roussel Uclaf Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
TW521073B (en) * 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2724169B1 (fr) * 1994-09-06 1997-01-03 Roussel Uclaf Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2741346B1 (fr) * 1995-11-16 1997-12-19 Roussel Uclaf Nouveau procede de preparation de derives phenylimidazolidine
FR2741342B1 (fr) * 1995-11-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
US6492553B1 (en) * 1998-01-29 2002-12-10 Aventis Pharamaceuticals Inc. Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
BR0111298A (pt) * 2000-06-28 2005-05-10 Bristol Myers Squibb Co Moduladores seletivos dos receptores de andrógenos e métodos para identificação, projeto e uso dos mesmos
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
AU2002364082A1 (en) 2001-12-19 2003-07-09 Bristol-Myers Squibb Company Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function
AU2004305075A1 (en) * 2003-12-19 2005-07-07 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies
NZ550102A (en) * 2004-02-24 2010-10-29 Univ California Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives)
US7709517B2 (en) * 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
AU2007245022A1 (en) * 2006-03-29 2007-11-08 The Regents Of The University Of California Diarylthiohydantoin compounds
DK3100727T3 (en) 2006-03-27 2018-11-12 Univ California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
WO2009055053A2 (en) 2007-10-26 2009-04-30 The Regents Of The University Of California Diarylhydantoin compounds as androgen receptor modulators
EP3124481B1 (en) 2010-02-16 2018-03-28 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
SG10201912719TA (en) 2012-09-26 2020-02-27 Aragon Pharmaceuticals Inc Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
JP7201694B2 (ja) 2017-10-16 2023-01-10 アラゴン ファーマシューティカルズ，インコーポレイテッド 非転移性去勢抵抗性前立腺癌の治療のための抗アンドロゲン剤

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE629779A (es) *
US3134663A (en) * 1957-07-23 1964-05-26 Geigy Chem Corp Herbicidal composition and method employing hydantoins
FR1405725A (fr) * 1963-08-23 1965-07-09 Shell Int Research Procédé de préparation de la 5, 5-diméthyl-4-iminohydantoine
DK122816B (da) * 1968-03-28 1972-04-17 Ciba Geigy Ag Analogifremgangsmåde til fremstilling af 3-aryl-5-methylhydantoiner.
US3690863A (en) * 1968-04-19 1972-09-12 Du Pont Esters of 3-(carboxyamino)-and 3-(thiocarboxyamino)-2-substituted crotonamides andtheir use as herbicides
DK123717B (da) * 1968-11-25 1972-07-24 Sumitomo Chemical Co 3-(3',5'-Dihalogenphenyl)-imidazolidin-2,4-dionderivater med mirobicid virkning.
JPS4916937B1 (es) * 1970-01-21 1974-04-25
US3676456A (en) * 1970-02-27 1972-07-11 Ciba Geigy Corp Derivatives of 3-aryl-5-alkylhydantoins
JPS5136332B1 (es) * 1970-12-09 1976-10-07
US4044021A (en) * 1971-10-21 1977-08-23 American Cyanamid Company Tetrasubstituted imidazolidine diuretics useful in the treatment of hyperaldosteronism
IL45459A (en) * 1973-09-03 1978-01-31 Ciba Geigy Ag 1-(dichlorofluoromethylthio)-3-phenyl-imidazolidine-2,4-dione derivatives their preparation and their use as bactericides and fungicides
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
JPS5315373A (en) * 1976-07-29 1978-02-13 Mitsubishi Chem Ind Ltd Hydantoin derivatives and fungicides containing same for agriculture and horiticulture
CA1138334A (en) * 1977-10-28 1982-12-28 Karl Bernauer Pharmaceutical preparations containing certain urea derivatives
US4358606A (en) * 1981-06-19 1982-11-09 Zoecon Corporation Esters of phenalkyloxycarbonylamino acids

Also Published As

Publication number Publication date
IT7829040A0 (it) 1978-10-24
US4407814A (en) 1983-10-04
SE7811194L (sv) 1979-04-29
BR7807097A (pt) 1979-05-08
FR2422643A1 (fr) 1979-11-09
CA1107744A (en) 1981-08-25
NZ188721A (en) 1984-11-09
EP0001813A1 (de) 1979-05-16
AT366374B (de) 1982-04-13
AT366671B (de) 1982-04-26
ES474592A1 (es) 1980-04-01
FI68618C (fi) 1985-10-10
JPS625145B2 (es) 1987-02-03
PT68705A (en) 1978-11-01
IE782130L (en) 1979-04-28
GB2008102A (en) 1979-05-31
ATA18281A (de) 1981-09-15
IL55773A (en) 1982-02-28
ES480109A1 (es) 1980-04-01
GB2008102B (en) 1982-07-07
EP0001813B1 (de) 1981-11-04
AU522536B2 (en) 1982-06-10
FI68618B (fi) 1985-06-28
CU34980A (es) 1981-12-04
NO151461B (no) 1985-01-02
NO783642L (no) 1979-05-02
FR2422643B1 (es) 1982-10-29
FI783170A7 (fi) 1979-04-29
AR220004A1 (es) 1980-09-30
IL55773A0 (en) 1978-12-17
JPS5470271A (en) 1979-06-05
DE2861289D1 (en) 1982-01-14
DK481678A (da) 1979-04-29
NO151461C (no) 1985-04-17
IT1099450B (it) 1985-09-18
NL7810563A (nl) 1979-05-02
PH13569A (en) 1980-06-26
IE47962B1 (en) 1984-08-08
DE2846946A1 (de) 1979-05-03
MC1220A1 (fr) 1979-07-20
AR219560A1 (es) 1980-08-29
US4482739A (en) 1984-11-13
ATA768978A (de) 1981-08-15
AU4096178A (en) 1980-05-01
GR70681B (es) 1982-12-20

Similar Documents

Publication Publication Date Title
ES480114A1 (es) Procedimiento para la preparacion de derivados de imidazoli-dina.
ES478051A1 (es) Procedimiento para la preparacion de nuevos nitroimidazoles.
IT1007056B (it) Apparecchiatura per il trattamento di pollame
DK543287D0 (da) 7beta-amino-3-cephem-3-amino-4-carboxylsyrederivater til anvendelse som mellemprodukter
SE411748B (sv) Cyklopropankarboxylsyraestrar till anvendning som pesticider
IL47529A (en) Substituted (1-(-4,4-bisphenylbutyl)-4-piperidyl-)1,3-dihydro-2h-benzimidazol-2-one derivatives and certain intermediates for obtaining such compounds,their preparation and pharmaceutical compositions containing them
BG33006A3 (en) Method for obtaining of n- (perfluoracil)- n- phosphonomethyl- glycine compounds
IT1041050B (it) Procedimento per il preriscaldamento di scisto oleoso
ES8600284A1 (es) Un procedimiento para la preparacion de nuevas benzamidas
IT1047412B (it) Giunto di compensazione per condutture
ES8502703A1 (es) Un procedimiento para la preparacion de nuevos derivados de tienopirimidina.
ES418114A1 (es) Un procedimiento para la preparacion de nuevas 5-metiltio pirimidinas.
ES480112A1 (es) Procedimiento para la preparacion de nuevos derivados de 2- iminoimidazolidina.
IT1019662B (it) Procedimento di trasporto per diffusione
IT1042316B (it) Procedimento per preparare 5 nitro i.4.4a.9a tetraidroantrachinone ad elavata purezza
ES425809A1 (es) Procedimiento para la preparacion de compuestos tetracicli-cos sustituidos por amino.
AR207664A1 (es) Un procedimiento para la preparacion de nuevos compuestos de 6-metil-8-(substituida)metilergolina
ES431287A1 (es) Procedimiento para preparar derivados de acido tricloroace-tamido-7 desacetoxi-3 cefalosporanico.
ES405555A1 (es) Procedimiento para la preparacion de derivados de ftalazo- na.
IT1014910B (it) Apparecchiatura per la produzione di tamponi fisiologici
IT1026907B (it) Procedimento per la sintesi di uree
IT1003925B (it) Procedimento per la preparazione di solfuri organici
IT1051036B (it) Procedimento per la sintesi di n metil uree
IT1047052B (it) Procedimento per la preparazione di composizioni antiparassitarie a base di derivati di formammidine sostituite
ES379299A1 (es) Procedimiento para la obtencion de derivados de indenopiri-dina.