ES489114A1 - Procedimiento de purificacion del acido ursodesoxicolico - Google Patents
Procedimiento de purificacion del acido ursodesoxicolicoInfo
- Publication number
- ES489114A1 ES489114A1 ES489114A ES489114A ES489114A1 ES 489114 A1 ES489114 A1 ES 489114A1 ES 489114 A ES489114 A ES 489114A ES 489114 A ES489114 A ES 489114A ES 489114 A1 ES489114 A1 ES 489114A1
- Authority
- ES
- Spain
- Prior art keywords
- purification process
- novel purification
- acid
- ursodesoxycholic acid
- ursodesoxycholic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000746 purification Methods 0.000 title abstract 2
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 abstract 3
- 229960001661 ursodiol Drugs 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salt Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedimiento de purificación del ácido ursodesoxicólico, caracterizado porque se trata una sal de metal alcalino del ácido ursodesoxicólico que ha de purificarse, en solución acuosa, en presencia de cloroformo, con un ácido , se recoge el producto cristalizado formado y se recupera de éste el ácido ursodesoxicólico purificado.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7913117A FR2457302A1 (fr) | 1979-05-23 | 1979-05-23 | Nouveau procede de purification de l'acide ursodesoxycholique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES489114A1 true ES489114A1 (es) | 1980-08-16 |
Family
ID=9225771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES489114A Expired ES489114A1 (es) | 1979-05-23 | 1980-03-01 | Procedimiento de purificacion del acido ursodesoxicolico |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4282161A (es) |
| JP (1) | JPS55154999A (es) |
| AU (1) | AU529723B2 (es) |
| BE (1) | BE883434A (es) |
| CA (1) | CA1134815A (es) |
| CH (1) | CH646181A5 (es) |
| DE (1) | DE3019837A1 (es) |
| DK (1) | DK145760C (es) |
| ES (1) | ES489114A1 (es) |
| FI (1) | FI67388C (es) |
| FR (1) | FR2457302A1 (es) |
| GB (1) | GB2052507B (es) |
| HU (1) | HU182687B (es) |
| IT (1) | IT1188938B (es) |
| NL (1) | NL8003000A (es) |
| PT (1) | PT71271B (es) |
| SE (1) | SE442119B (es) |
| ZA (1) | ZA801664B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2444048B1 (es) | 1978-12-15 | 1981-08-14 | Roussel Uclaf | |
| IT1132055B (it) * | 1980-05-14 | 1986-06-25 | Erregierre Spa | Processo per la preparazione di acido ursodesossicolico ad alta purezza |
| IT1167478B (it) * | 1981-07-24 | 1987-05-13 | Carlo Scolastico | Derivati dell'acido ursodesossicolico |
| IT1150756B (it) * | 1982-04-02 | 1986-12-17 | Zambon Spa | Procedimento per preparare l'acido 3alfa, 7beta-diidrossi-5beta-colanico |
| DE3930696A1 (de) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
| JP4021327B2 (ja) | 2001-03-12 | 2007-12-12 | インターセプト ファーマスーティカル インコーポレイテッド | Ｆｘｒに対する作用薬としてのステロイド |
| CN114349810A (zh) * | 2021-12-30 | 2022-04-15 | 北京岳达生物科技有限公司 | 甾类化合物通用的手性拆分方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2404102C2 (de) * | 1974-01-25 | 1975-11-06 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Reinigung roher Chenodesoxycholsäure |
| JPS52153954A (en) * | 1976-06-18 | 1977-12-21 | Tokyo Tanabe Co | Purification method of ulsodeoxycholic acid |
-
1979
- 1979-05-23 FR FR7913117A patent/FR2457302A1/fr active Granted
-
1980
- 1980-01-31 SE SE8000776A patent/SE442119B/sv not_active IP Right Cessation
- 1980-03-01 ES ES489114A patent/ES489114A1/es not_active Expired
- 1980-03-21 ZA ZA00801664A patent/ZA801664B/xx unknown
- 1980-04-02 FI FI801054A patent/FI67388C/fi not_active IP Right Cessation
- 1980-04-17 JP JP4963380A patent/JPS55154999A/ja active Granted
- 1980-04-30 DK DK186780A patent/DK145760C/da not_active IP Right Cessation
- 1980-05-05 US US06/146,496 patent/US4282161A/en not_active Expired - Lifetime
- 1980-05-20 PT PT71271A patent/PT71271B/pt unknown
- 1980-05-22 HU HU801293A patent/HU182687B/hu not_active IP Right Cessation
- 1980-05-22 CA CA000352535A patent/CA1134815A/fr not_active Expired
- 1980-05-22 CH CH401980A patent/CH646181A5/fr not_active IP Right Cessation
- 1980-05-22 AU AU58682/80A patent/AU529723B2/en not_active Ceased
- 1980-05-22 BE BE0/200722A patent/BE883434A/fr not_active IP Right Cessation
- 1980-05-22 IT IT48762/80A patent/IT1188938B/it active
- 1980-05-23 NL NL8003000A patent/NL8003000A/nl not_active Application Discontinuation
- 1980-05-23 GB GB8017124A patent/GB2052507B/en not_active Expired
- 1980-05-23 DE DE19803019837 patent/DE3019837A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FI801054A7 (fi) | 1980-11-24 |
| JPS55154999A (en) | 1980-12-02 |
| DK145760C (da) | 1983-08-15 |
| US4282161A (en) | 1981-08-04 |
| JPS6351156B2 (es) | 1988-10-13 |
| CH646181A5 (fr) | 1984-11-15 |
| PT71271A (fr) | 1980-05-31 |
| DK186780A (da) | 1980-11-24 |
| SE8000776L (sv) | 1980-11-24 |
| AU529723B2 (en) | 1983-06-16 |
| DE3019837C2 (es) | 1991-05-16 |
| NL8003000A (nl) | 1980-11-25 |
| AU5868280A (en) | 1980-11-27 |
| IT8048762A0 (it) | 1980-05-22 |
| GB2052507B (en) | 1983-08-10 |
| PT71271B (en) | 1982-10-15 |
| FR2457302A1 (fr) | 1980-12-19 |
| DE3019837A1 (de) | 1980-11-27 |
| CA1134815A (fr) | 1982-11-02 |
| ZA801664B (en) | 1981-03-25 |
| DK145760B (da) | 1983-02-21 |
| FI67388C (fi) | 1985-03-11 |
| FI67388B (fi) | 1984-11-30 |
| IT8048762A1 (it) | 1981-11-22 |
| BE883434A (fr) | 1980-11-24 |
| SE442119B (sv) | 1985-12-02 |
| HU182687B (en) | 1984-02-28 |
| FR2457302B1 (es) | 1982-10-15 |
| GB2052507A (en) | 1981-01-28 |
| IT1188938B (it) | 1988-01-28 |
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