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ES471593A1 - PROCEDURE FOR PREPARING NEW INDOLIC DERIVATIVES - Google Patents

PROCEDURE FOR PREPARING NEW INDOLIC DERIVATIVES

Info

Publication number
ES471593A1
ES471593A1 ES471593A ES471593A ES471593A1 ES 471593 A1 ES471593 A1 ES 471593A1 ES 471593 A ES471593 A ES 471593A ES 471593 A ES471593 A ES 471593A ES 471593 A1 ES471593 A1 ES 471593A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
alkylamino
procedure
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES471593A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES471593A1 publication Critical patent/ES471593A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para preparar nuevos derivado indólicos, de fórmula I, **(Fórmula)** en donde A es 1,4-ciclohexilideno o trimetileno facultativamente substituido por alquilo (C1-4) y R1 es hidrógeno o alquilo (C1-5), o A junto con R1 y el átomo de nitrógeno al que está unido R1, forman un radical 4-piperidilo, R2 es hidrógeno o alquilo (C1-5), R3 es alquilo (C1-4); cicloalquilo (C3-6);amino; alquilamino (C1-4); dialquilamino (C1-4); fenilamino es donde el anillo fenílico no está substituido o está monosubstituido, disubstituido o trisubstituido independientemente por halógeno, alquilo (C1-4); fenilo o bencilo en donde los anillos fenílicos no están substituidos o están monosubstituídos, disubstituidos o trisubstituidos independientemente por halógeno, hidroxi, alquilo (1-4), alcoxi (C1-4) o dialquilamino (C1-4); 2-, 3- ó 4-piridil-metilo; o un heterociclo aromático de 5 ó 6 miembros conteniendo un heteroátomo seleccionado de nitrógeno, oxígeno o azufre y facultativamente uno o dos átomos denitrógeno adicionales, R4 es hidrógeno, cloro, bromo o alquilo (C1-4), R5 es hidrógeno, alquilo (C1-4), alcoxi (C1-4) o alquiltio (C1-4), y X es -CO- o -CS-, y sus sales.Procedure to prepare new indole derivatives, of formula I, **(Formula)** where A is 1,4-cyclohexylidene or trimethylene optionally substituted by alkyl (C1-4) and R1 is hydrogen or alkyl (C1-5), or A together with R1 and the nitrogen atom to which R1 is attached, form a 4-piperidyl radical, R2 is hydrogen or (C1-5)alkyl, R3 is (C1-4)alkyl; (C3-6)cycloalkyl;amino; (C1-4)alkylamino; di(C1-4)alkylamino; phenylamino is where the phenyl ring is unsubstituted or is independently mono-, di-, or tri-substituted by halogen, (C1-4)alkyl; phenyl or benzyl in which the phenyl rings are unsubstituted or are independently mono-, di- or tri-substituted by halogen, hydroxy, (1-4)alkyl, (1-4C)alkoxy or di(1-4C)alkylamino; 2-, 3- or 4-pyridyl-methyl; or a 5- or 6-membered aromatic heterocycle containing a heteroatom selected from nitrogen, oxygen or sulfur and optionally one or two additional nitrogen atoms, R4 is hydrogen, chlorine, bromine or (C1-4)alkyl, R5 is hydrogen, (C1-4)alkyl -4), (1-4C)alkoxy or (1-4C)alkylthio, and X is -CO- or -CS-, and salts thereof.

ES471593A 1977-07-12 1978-07-10 PROCEDURE FOR PREPARING NEW INDOLIC DERIVATIVES Expired ES471593A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH858977 1977-07-12
CH300878 1978-03-20

Publications (1)

Publication Number Publication Date
ES471593A1 true ES471593A1 (en) 1979-10-01

Family

ID=25691930

Family Applications (1)

Application Number Title Priority Date Filing Date
ES471593A Expired ES471593A1 (en) 1977-07-12 1978-07-10 PROCEDURE FOR PREPARING NEW INDOLIC DERIVATIVES

Country Status (14)

Country Link
EP (1) EP0000355B1 (en)
JP (1) JPS5436259A (en)
AU (1) AU521641B2 (en)
CA (1) CA1114381A (en)
DE (1) DE2861502D1 (en)
DK (1) DK300978A (en)
ES (1) ES471593A1 (en)
FI (1) FI782138A7 (en)
IE (1) IE47209B1 (en)
IL (1) IL55116A (en)
IT (1) IT7850140A0 (en)
NZ (1) NZ187813A (en)
PH (1) PH14993A (en)
PT (1) PT68270A (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2960547D1 (en) * 1978-02-24 1981-11-05 Pfizer Ltd 3-(imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them
US4634713A (en) * 1982-05-28 1987-01-06 Ciba-Geigy Corporation Antihypertensive 3-(ureidocyclohexyleneamino)propane-1,2-diol derivatives
JPH0283380A (en) * 1988-09-21 1990-03-23 Kotobuki Seiyaku Kk Novel diamine derivative, antiarrhythmic agent and production thereof
FR2642422A1 (en) * 1988-12-22 1990-08-03 Roussel Uclaf NOVEL ACYLATED POLYAMINES, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS FUNGICIDES
EP0650476B1 (en) * 1993-04-07 2002-06-26 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing n-acylated 4-amino piperidine derivatives as active ingredients
MY142362A (en) 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
US11764679B2 (en) 2020-01-15 2023-09-19 Solaredge Technologies Ltd. Power device
CN116478134B (en) * 2022-01-17 2025-07-25 上海医药工业研究院有限公司 SSRI/5-HT1ADouble-target antidepressant formylpiperidine compound and preparation method and application thereof
CN115433164B (en) * 2022-09-14 2023-12-12 南京师范大学 Nicotinamide derivative, preparation method thereof and application thereof in resisting aging and prolonging life

Also Published As

Publication number Publication date
JPS5436259A (en) 1979-03-16
AU521641B2 (en) 1982-04-22
AU3793978A (en) 1980-01-17
PT68270A (en) 1978-08-01
DE2861502D1 (en) 1982-02-25
FI782138A7 (en) 1979-01-13
PH14993A (en) 1982-03-22
NZ187813A (en) 1981-03-16
EP0000355A1 (en) 1979-01-24
CA1114381A (en) 1981-12-15
DK300978A (en) 1979-01-13
IL55116A0 (en) 1978-09-29
IL55116A (en) 1982-02-28
IT7850140A0 (en) 1978-07-03
EP0000355B1 (en) 1982-01-06
IE47209B1 (en) 1984-01-11
IE781382L (en) 1979-01-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009