[go: up one dir, main page]

ES479206A1 - Un procedimiento para la preparacion de n-heterociclil-4- piperidinamina. - Google Patents

Un procedimiento para la preparacion de n-heterociclil-4- piperidinamina.

Info

Publication number
ES479206A1
ES479206A1 ES479206A ES479206A ES479206A1 ES 479206 A1 ES479206 A1 ES 479206A1 ES 479206 A ES479206 A ES 479206A ES 479206 A ES479206 A ES 479206A ES 479206 A1 ES479206 A1 ES 479206A1
Authority
ES
Spain
Prior art keywords
preparation
intermediates
piperidinamines
heterocyclyl
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479206A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26670178&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES479206(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/002,276 external-priority patent/US4219559A/en
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of ES479206A1 publication Critical patent/ES479206A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Nuevas N-heterociclil-4-4-piperidinaminas donde el radical heterocíclico es un radical 1H- bencimidazol-2-ilo o 3H-imidazo {4,5-b} piridin-2-ilo opcionalmente sustituido, siendo útiles estos compuestos como agentes antihistamínicos.
ES479206A 1978-04-03 1979-04-02 Un procedimiento para la preparacion de n-heterociclil-4- piperidinamina. Expired ES479206A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89253478A 1978-04-03 1978-04-03
US06/002,276 US4219559A (en) 1979-01-10 1979-01-10 N-Heterocyclyl-4-piperidinamines

Publications (1)

Publication Number Publication Date
ES479206A1 true ES479206A1 (es) 1979-12-16

Family

ID=26670178

Family Applications (1)

Application Number Title Priority Date Filing Date
ES479206A Expired ES479206A1 (es) 1978-04-03 1979-04-02 Un procedimiento para la preparacion de n-heterociclil-4- piperidinamina.

Country Status (29)

Country Link
EP (1) EP0005318B1 (es)
JP (2) JPS54151982A (es)
AT (1) AT373887B (es)
AU (1) AU523352B2 (es)
BG (1) BG38164A3 (es)
CA (1) CA1140119A (es)
CS (1) CS256358B2 (es)
CY (1) CY1250A (es)
DE (1) DE2961740D1 (es)
DK (1) DK169325B1 (es)
EG (1) EG13913A (es)
ES (1) ES479206A1 (es)
FI (1) FI64801C (es)
GR (1) GR64907B (es)
HK (1) HK3184A (es)
HU (1) HU182965B (es)
IE (1) IE47818B1 (es)
IL (1) IL56992A (es)
MY (1) MY8500046A (es)
NO (2) NO154058C (es)
NZ (1) NZ189978A (es)
PH (1) PH15877A (es)
PL (1) PL123380B1 (es)
PT (1) PT69429A (es)
RO (1) RO79320A (es)
SG (1) SG29883G (es)
SU (1) SU1056902A3 (es)
YU (2) YU42484B (es)
ZA (1) ZA791557B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA19091A1 (fr) * 1980-03-10 1981-10-01 Janssen Pharmaceutica Nv Nouveaux derives de i-(4-aryl-cyclohexyl)piperidine .
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
IN156065B (es) * 1982-07-12 1985-05-04 Janssen Pharmaceutica Nv
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
EP0144101B1 (en) * 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
PL144514B1 (en) * 1984-01-09 1988-06-30 Janssen Pharmaceutica Nv Method of obtaining novel derivatives of n-/4-piperidinolo/-2-imidazoloamine
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
ATE79620T1 (de) * 1986-02-03 1992-09-15 Janssen Pharmaceutica Nv N-heterozyklische-4-piperidinamine enthaltende anti-histaminische zusammensetzungen.
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
FR2618435B1 (fr) * 1987-07-23 1989-10-27 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
US5210091A (en) * 1991-06-24 1993-05-11 Neurosearch A/S Imidazole compounds and their use
FI955523A7 (fi) * 1993-05-20 1995-11-16 Kissei Pharmaceutical 1-(2-bentsimidatsolyyli)-1,5-diatsasyklo-oksataaniyhdisteet
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
HUP0101048A2 (hu) * 1998-03-06 2001-10-28 Janssen Pharmaceutica N.V. Glicin transzport gátló hatású 4,4 bisz[(4-fluorfenil)butil]-1-(piperazinil és piperidinil)-származékok és gyógyászati alkalmazásuk
CZ20014573A3 (cs) 1999-06-28 2002-05-15 Janssen Pharmaceutica N. V. Inhibitory replikace respiračně syncyciálního viru
ES2215683T3 (es) 1999-06-28 2004-10-16 Janssen Pharmaceutica N.V. Inhibidores de la replicacion del virus sincitial respiratorio.
CZ20014574A3 (cs) 1999-06-28 2002-05-15 Janssen Pharmaceutica N. V. Inhibitory replikace respiračně syncyciálního viru
NZ520240A (en) 2000-03-06 2005-04-29 Acadia Pharm Inc Azacyclic compounds for use in the treatment of serotonin related diseases
CA2436467A1 (en) 2001-02-02 2002-08-15 Teva Pharmaceutical Industries Ltd. Processes for the production of substituted 2-(2-pyridylmethyl) sulfinyl-1h-benzimidazoles
ATE466014T1 (de) 2001-12-28 2010-05-15 Acadia Pharm Inc Spiroazacyclische verbindungen als monoaminrezeptormodulatoren
EP1490090A4 (en) 2002-02-22 2006-09-20 New River Pharmaceuticals Inc SYSTEMS FOR DELIVERING ACTIVE AGENTS AND METHODS FOR PROTECTING AND DELIVERING ACTIVE AGENTS
BR0312217A (pt) 2002-06-24 2005-05-10 Acadia Pharm Inc Compostos, métodos de inibição da atividade/ativação de um receptor monoaminérgico e método de tratamento de condição doentia associada a um receptor de monoaminergético
US7538222B2 (en) 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
US7253186B2 (en) 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
WO2004064738A2 (en) 2003-01-16 2004-08-05 Acadia Pharmaceuticals Inc. Selective serotonin 2a/2c receptor inverse agonists as therapeutics for neurodegenerative diseases
WO2005058869A1 (en) 2003-12-18 2005-06-30 Tibotec Pharmaceuticals Ltd. Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication
ATE501135T1 (de) * 2003-12-18 2011-03-15 Tibotec Pharm Ltd Piperidinamino-benzimidazol-derivate al respiratorisches syncytialvirus replikation inhibitoren
HRP20110313T1 (hr) 2003-12-18 2011-05-31 Tibotec Pharmaceuticals 5-ili 6-supstituirani derivati benzimidazola kao inhibitori respiratorne sincitijalne virusne replikacije
US7820695B2 (en) 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
US20050261278A1 (en) 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US7790899B2 (en) 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
PL2289879T3 (pl) 2004-09-27 2015-05-29 Acadia Pharm Inc Synteza formy krystalicznej soli winianowej n-(4-fluorobenzylo)-n-(1-metylopiperydyn-4-ylo)-n'-(4-(2-metylopropyloksy)fenylometylo)karbamidu
ES2423485T3 (es) 2007-03-19 2013-09-20 Acadia Pharmaceuticals Inc. Asociaciones de agonistas y antagonistas inversos 5-HT2A con antipsicóticos
SI3325444T1 (sl) 2015-07-20 2021-11-30 Acadia Pharmaceuticals Inc. Postopki za pripravo N-(4-fluorobenzil)-N-(1-metilpiperidin-4-il)-N'- (4-(2-metilpropiloksi)fenilmetil)karbamida in njegove tartratne soli in polimorfne oblike C
WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
EP3558311A1 (en) 2016-12-20 2019-10-30 Acadia Pharmaceuticals Inc. Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
US11135211B2 (en) 2017-04-28 2021-10-05 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
EP3675827A1 (en) 2017-08-30 2020-07-08 Acadia Pharmaceuticals Inc. Formulations of pimavanserin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2857391A (en) * 1955-04-15 1958-10-21 Merck & Co Inc Aminomethylbenzimidazoles
US2971005A (en) * 1958-10-17 1961-02-07 Merck & Co Inc Nu-substituted derivatives of 2-benzylaminobenzimidazoles
BE788065A (fr) * 1971-08-26 1973-02-26 Degussa Nouvelles aza-benzimidazoles et procede pour leur preparation

Also Published As

Publication number Publication date
JPH0240666B2 (es) 1990-09-12
EP0005318B1 (en) 1982-01-06
PH15877A (en) 1983-04-13
FI791084A7 (fi) 1979-10-04
CY1250A (en) 1984-08-31
BG38164A3 (bg) 1985-10-15
YU50283A (en) 1983-12-31
JPS641477B2 (es) 1989-01-11
PT69429A (pt) 1979-05-01
YU42484B (en) 1988-10-31
JPH01117880A (ja) 1989-05-10
RO79320A (ro) 1982-08-17
PL123380B1 (en) 1982-10-30
YU78479A (en) 1983-10-31
IE47818B1 (en) 1984-06-27
AT373887B (de) 1984-02-27
AU4529679A (en) 1979-10-18
IE790676L (en) 1979-10-03
SU1056902A3 (ru) 1983-11-23
NZ189978A (en) 1984-05-31
CS256358B2 (en) 1988-04-15
IL56992A0 (en) 1979-07-25
NO154090C (no) 1986-07-16
CS222779A2 (en) 1987-03-12
HK3184A (en) 1984-01-20
AU523352B2 (en) 1982-07-22
JPS54151982A (en) 1979-11-29
EG13913A (en) 1982-09-30
HU182965B (en) 1984-03-28
FI64801C (fi) 1984-01-10
IL56992A (en) 1983-03-31
NO154058B (no) 1986-04-01
NO154058C (no) 1986-07-09
NO154090B (no) 1986-04-07
DK129879A (da) 1979-10-04
NO842563L (no) 1979-10-04
ATA242579A (de) 1983-07-15
PL214648A1 (es) 1980-03-24
FI64801B (fi) 1983-09-30
DK169325B1 (da) 1994-10-10
YU43158B (en) 1989-04-30
CA1140119A (en) 1983-01-25
SG29883G (en) 1984-04-19
ZA791557B (en) 1980-11-26
DE2961740D1 (en) 1982-02-25
EP0005318A1 (en) 1979-11-14
MY8500046A (en) 1985-12-31
NO791097L (no) 1979-10-04
GR64907B (en) 1980-06-07

Similar Documents

Publication Publication Date Title
ES479206A1 (es) Un procedimiento para la preparacion de n-heterociclil-4- piperidinamina.
GB2126226B (en) Pyridine derivatives
ES8603477A1 (es) Procedimiento para preparar una 1h-imidazo (4, 5-c) quinolin-4-amina
GR64431B (en) Method for the preparation of new 4-amino 5-alkylsulfonyl orthoanisamides derivatives
IL63980A (en) N-thiazol-4-ylmethylthioalkyl derivatives used as antiulcer agents and process for their preparation
AU536920B2 (en) Hydroxypropyl-triazole derivatives and their use as antimycotic agents
RO86850A (ro) Procedeu pentru prepararea unor 2-fenilimidazo/4,5c/-piridine
BG40803A3 (bg) Метод за получаване на арилциклобутилалкиламинови производни
PH20896A (en) Pyrazolopyridines, pharmaceutical composition containing same and method of use thereof
PT84718A (en) Process for the preparation of insecticidal compositions containing five-membered heterocyclic derivatives of n:-substituted-n,n:-diacylhydrazines
PT72654A (en) Process for the preparation of pyrazolopyridine derivatives useful as cardiotonics
ES8800217A1 (es) Procedimiento para la preparacion de acidos 4-(isoxazolil)-tiazol-2-oxamicos y sus derivados
JPS51115491A (en) Method for preparing 77* *44hydroxyy1*5 naphthyridinee33carboxyamino ** phenylacetamido*cephalosporins
BG44203A3 (en) Method for preparing of 2- oxyindol- 1- carboxamides
BG34910A3 (en) Method for preparing cephalosporines
BG39977A3 (en) Method for preparing derivatives of furyloxazolylacetic acid
DE2861598D1 (en) 1h-pyrimido-(4,5-c)-1,2-diazepines, methods for their preparation and compositions containing them; their use as intermediates for heterocyclic transformations.
BG36346A3 (bg) Метод за получаване на имидазо/4,5,-в/-пиридини и -пиримидини
ES474052A1 (es) Procedimiento para la obtencion de 1,4-dihidropiridazinas 1-n-sustituidas.
SE8400118D0 (sv) Substituted carboxy-thiazolo(3,2-a)pyrimidine derivatives and process for their preparation
YU158691A (sh) 2-(4-PIPERIDINIL)-1H-PIRIDO[4,3-b]INDOL-1-ONI IN SORODNE SPOJINE, INTERMEDIATI IN POSTOPEK ZA NJIHOVO PROPRAVO
BG36937A3 (bg) Метод за получаване на производни на 5,6,7,7а-тетрахидро- 4н-тиен(3,2-с)пиридин-2-они
BG41128A3 (en) Method for prepparing intermediary compounds for preparation of benzothiazine- carboxamides
ES504246A0 (es) Procedimiento de preparar derivados de piridacino (4,5-b) quinoxalina-5,10-dioxido
PT73948B (en) Process for the preparation of biologically active heterobicyclic hydroximidates and thiolhydroximidates and carbamate ester derivatives thereof

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991217