ES476564A1 - A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF EMIDA-ROL. - Google Patents
A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF EMIDA-ROL.Info
- Publication number
- ES476564A1 ES476564A1 ES476564A ES476564A ES476564A1 ES 476564 A1 ES476564 A1 ES 476564A1 ES 476564 A ES476564 A ES 476564A ES 476564 A ES476564 A ES 476564A ES 476564 A1 ES476564 A1 ES 476564A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- hydrogen
- preparation
- derivatives
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process for the preparation of imidazole derivatives of formula (I) ** formula **, where R1 and R2 each represents hydrogen or ** formula **, R3 is hydrogen or fluorine and n is 1,2 or 3, with the proviso that one of the groups R1 or R2 is other than hydrogen, or a pharmaceutically acceptable acid addition salt thereof, the process characterized by comprising reacting a compound of formula (II) ** formula **, where X is halogen with an atomic weight of approximately 35 to 127 or ** formula **, where R4 is hydrogen, chlorine or methyl with a compound of formula III ** formula **, where Z is sodium, potassium or lithium and R1 and R2 are those defined above, in an inert atmosphere and in the presence of an inert organic solvent. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90315578A | 1978-05-05 | 1978-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES476564A1 true ES476564A1 (en) | 1979-12-01 |
Family
ID=25417025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES476564A Expired ES476564A1 (en) | 1978-05-05 | 1979-01-03 | A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF EMIDA-ROL. |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS54145664A (en) |
| AU (1) | AU4305579A (en) |
| CA (1) | CA1110634A (en) |
| DK (1) | DK585878A (en) |
| ES (1) | ES476564A1 (en) |
| FI (1) | FI783953A7 (en) |
| IL (1) | IL56308A0 (en) |
| PT (1) | PT69182A (en) |
-
1978
- 1978-12-21 FI FI783953A patent/FI783953A7/en not_active IP Right Cessation
- 1978-12-26 IL IL56308A patent/IL56308A0/en unknown
- 1978-12-28 DK DK585878A patent/DK585878A/en unknown
- 1978-12-28 JP JP16129978A patent/JPS54145664A/en active Pending
- 1978-12-29 CA CA318,825A patent/CA1110634A/en not_active Expired
-
1979
- 1979-01-02 AU AU43055/79A patent/AU4305579A/en not_active Abandoned
- 1979-01-03 ES ES476564A patent/ES476564A1/en not_active Expired
- 1979-02-06 PT PT6918279A patent/PT69182A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT69182A (en) | 1979-03-01 |
| AU4305579A (en) | 1979-11-08 |
| DK585878A (en) | 1979-11-06 |
| JPS54145664A (en) | 1979-11-14 |
| FI783953A7 (en) | 1979-11-06 |
| IL56308A0 (en) | 1979-03-12 |
| CA1110634A (en) | 1981-10-13 |
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