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ES474975A1 - Un metodo de preparar acido 6.11-dihidro-11-oxodibenz (b,e) oxepin-2-acetico - Google Patents

Un metodo de preparar acido 6.11-dihidro-11-oxodibenz (b,e) oxepin-2-acetico

Info

Publication number
ES474975A1
ES474975A1 ES474975A ES474975A ES474975A1 ES 474975 A1 ES474975 A1 ES 474975A1 ES 474975 A ES474975 A ES 474975A ES 474975 A ES474975 A ES 474975A ES 474975 A1 ES474975 A1 ES 474975A1
Authority
ES
Spain
Prior art keywords
oxodibenz
oxepin
dihydro
preparation
acetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES474975A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES474975A1 publication Critical patent/ES474975A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un método de preparar ácido 6,11-dihidro-11-oxodibenz[b,e]oxepin-2-acético de la fórmula **fórmula** que comprende ciclizar cloruro de 4-benciloxi-3-(clorocarbonil)-fenilacetilo de la fórmula III en condiciones de Friedel Crafts.
ES474975A 1977-10-19 1978-11-10 Un metodo de preparar acido 6.11-dihidro-11-oxodibenz (b,e) oxepin-2-acetico Expired ES474975A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/843,482 US4118401A (en) 1977-10-19 1977-10-19 Preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid and precursors therefor

Publications (1)

Publication Number Publication Date
ES474975A1 true ES474975A1 (es) 1980-02-16

Family

ID=25290114

Family Applications (2)

Application Number Title Priority Date Filing Date
ES474162A Expired ES474162A1 (es) 1977-10-19 1978-10-13 Un metodo mejorado de preparar acido 6,11-dihidro-11-oxodi- benz (b,e) oxepin-2-acetico
ES474975A Expired ES474975A1 (es) 1977-10-19 1978-11-10 Un metodo de preparar acido 6.11-dihidro-11-oxodibenz (b,e) oxepin-2-acetico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES474162A Expired ES474162A1 (es) 1977-10-19 1978-10-13 Un metodo mejorado de preparar acido 6,11-dihidro-11-oxodi- benz (b,e) oxepin-2-acetico

Country Status (9)

Country Link
US (4) US4118401A (es)
JP (1) JPS5461189A (es)
AR (2) AR223329A1 (es)
AT (1) AT369737B (es)
CA (1) CA1110636A (es)
ES (2) ES474162A1 (es)
HU (1) HU180245B (es)
NL (1) NL7810456A (es)
SE (2) SE7810895L (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4118401A (en) * 1977-10-19 1978-10-03 American Hoechst Corporation Preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid and precursors therefor
US4576960A (en) * 1981-12-23 1986-03-18 Hoechst Roussel Pharmaceuticals Incorporated 6,11-Dihydro-11-oxo-dibenz[b,e]oxepin derivatives
US4515946A (en) * 1981-12-23 1985-05-07 Hoechst-Roussel Pharmaceuticals Inc. 6,11-Dihydro-11-oxo-dibenz-[b,e]oxepin derivatives
US7687646B2 (en) * 2006-03-28 2010-03-30 Azad Pharmaceutical Ingredients, Ag Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof
US9815815B2 (en) 2013-01-10 2017-11-14 Pulmokine, Inc. Non-selective kinase inhibitors
EP3054937B1 (en) 2013-10-11 2023-07-26 Pulmokine, Inc. Spray dry formulations
CN106518833A (zh) * 2015-09-15 2017-03-22 江苏吉贝尔药业股份有限公司 一种新的6，11-二氢-11-氧代二苯并［b，e］噁庚因-2-乙酸制备方法
KR102543227B1 (ko) 2016-10-27 2023-06-13 풀모킨 인코포레이티드 폐고혈압을 치료하기 위한 병용 요법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1409411A (fr) * 1964-07-16 1965-08-27 Imprimerie Darboy Perfectionnements apportés aux moyens pour l'élaboration d'emballages transparents étanches et aux emballages correspondants
FR1409441A (fr) * 1964-07-17 1965-08-27 France Ministre Des Armees Perfectionnements au procédé de préparation d'acides para-alkoxy-phénylalkylène-carboxyliques
YU204274A (en) 1973-07-24 1982-06-30 Hoechst Ag Process for preparing new dibenzoxepin derivatives
DE2600768C2 (de) * 1975-02-04 1983-10-27 Hoechst Ag, 6230 Frankfurt Verfahren zur Herstellung von 6,11-Dihydro-11-oxodibenz[b,e]-oxepin-alkansäuren
US4118401A (en) * 1977-10-19 1978-10-03 American Hoechst Corporation Preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid and precursors therefor

Also Published As

Publication number Publication date
AR223329A1 (es) 1981-08-14
US4160781A (en) 1979-07-10
HU180245B (en) 1983-02-28
SE7810895L (sv) 1979-04-20
AT369737B (de) 1983-01-25
NL7810456A (nl) 1979-04-23
SE8301997D0 (sv) 1983-04-11
US4118401A (en) 1978-10-03
ATA747878A (de) 1982-06-15
SE8301997L (sv) 1983-04-11
AR224905A1 (es) 1982-01-29
US4153790A (en) 1979-05-08
JPS5461189A (en) 1979-05-17
US4153791A (en) 1979-05-08
ES474162A1 (es) 1979-09-01
CA1110636A (en) 1981-10-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971201