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ES469574A1 - A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS. - Google Patents

A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS.

Info

Publication number
ES469574A1
ES469574A1 ES469574A ES469574A ES469574A1 ES 469574 A1 ES469574 A1 ES 469574A1 ES 469574 A ES469574 A ES 469574A ES 469574 A ES469574 A ES 469574A ES 469574 A1 ES469574 A1 ES 469574A1
Authority
ES
Spain
Prior art keywords
homosteroid
formula
fluorine
denotes
chlorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES469574A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES469574A1 publication Critical patent/ES469574A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Anti-inflammatory D-homosteroids of the formula < IMAGE > in which the dotted 1,2 bond denotes an optional C-C bond R<6> denotes hydrogen, fluorine, chlorine or methyl R<9> denotes hydrogen, fluorine or chlorine and R<17a> denotes hydroxyl or acyloxy, where R<9> is to be fluorine or chlorine if R<6> is hydrogen in a 17 alpha -hydroxy compound or R<6> is fluorine in a singly unsaturated 17a-hydroxy compound, are prepared by treating a corresponding 21-iodo-D-homosteroid with a reducing agent. A singly unsaturated D-homosteroid of the formula I can then be dehydrogenated to the doubly unsaturated D-homosteroid of the formula I, a 6-unsubstituted D-homosteroid of the formula I can be fluorinated or chlorinated in position 6, and a 17a alpha -hydroxy-D-homosteroid of the formula I can be acylated in position 17a alpha .
ES469574A 1976-09-03 1978-05-08 A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS. Expired ES469574A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT656076A AT356301B (en) 1976-09-03 1976-09-03 METHOD FOR THE PRODUCTION OF NEW D-HOMOSTEROIDS

Publications (1)

Publication Number Publication Date
ES469574A1 true ES469574A1 (en) 1978-12-01

Family

ID=3587531

Family Applications (3)

Application Number Title Priority Date Filing Date
ES462076A Expired ES462076A1 (en) 1976-09-03 1977-09-02 A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS.
ES469573A Expired ES469573A1 (en) 1976-09-03 1978-05-08 A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS.
ES469574A Expired ES469574A1 (en) 1976-09-03 1978-05-08 A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES462076A Expired ES462076A1 (en) 1976-09-03 1977-09-02 A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS.
ES469573A Expired ES469573A1 (en) 1976-09-03 1978-05-08 A PROCEDURE FOR THE PREPARATION OF D-HOMOSTEROIDS.

Country Status (30)

Country Link
JP (1) JPS5910680B2 (en)
AR (1) AR220320A1 (en)
AT (1) AT356301B (en)
AU (1) AU516174B2 (en)
BE (1) BE858354A (en)
CA (1) CA1098897A (en)
CH (4) CH629827A5 (en)
DE (1) DE2738363A1 (en)
DK (1) DK140947B (en)
ES (3) ES462076A1 (en)
FI (1) FI57600C (en)
FR (1) FR2363580A1 (en)
GB (1) GB1586504A (en)
GR (1) GR73039B (en)
HK (1) HK26484A (en)
HU (2) HU176255B (en)
IE (1) IE45671B1 (en)
IL (1) IL52831A (en)
IT (1) IT1085032B (en)
LU (1) LU78064A1 (en)
MC (1) MC1166A1 (en)
MY (1) MY8500293A (en)
NL (1) NL182314C (en)
NO (1) NO145621C (en)
NZ (1) NZ185046A (en)
PH (1) PH14434A (en)
PT (1) PT66983B (en)
SE (1) SE440783B (en)
YU (2) YU40009B (en)
ZA (1) ZA775192B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1188616A (en) * 1981-06-11 1985-06-11 Hoffmann-La Roche Limited Pharmaceutical preparations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH571018A5 (en) * 1972-03-29 1975-12-31 Hoffmann La Roche
SE418402B (en) * 1973-03-28 1981-05-25 Hoffmann La Roche FURTHER DEVELOPMENT OF PROCEDURES ACCORDING TO PATENT 404 530 FOR THE PREPARATION OF D-HOMOSTEROIDS
DE2349023A1 (en) * 1973-09-26 1975-04-10 Schering Ag NEW D-HOMO-STEROIDS
CH601351A5 (en) * 1973-09-26 1978-07-14 Hoffmann La Roche
DE2349022A1 (en) * 1973-09-26 1975-04-10 Schering Ag NEW D-HOMO-STEROIDS
DE2442615A1 (en) * 1974-09-04 1976-03-18 Schering Ag NEW D-HOMO-STEROIDS

Also Published As

Publication number Publication date
ZA775192B (en) 1978-07-26
FR2363580A1 (en) 1978-03-31
MC1166A1 (en) 1978-06-02
AU2830477A (en) 1979-03-08
CH629830A5 (en) 1982-05-14
AT356301B (en) 1980-04-25
IE45671L (en) 1978-03-03
MY8500293A (en) 1985-12-31
ATA656076A (en) 1979-09-15
NZ185046A (en) 1980-10-08
HK26484A (en) 1984-03-30
JPS5910680B2 (en) 1984-03-10
FI57600B (en) 1980-05-30
IL52831A0 (en) 1977-10-31
NL182314C (en) 1988-02-16
AU516174B2 (en) 1981-05-21
CA1098897A (en) 1981-04-07
HU176255B (en) 1981-01-28
YU40089B (en) 1985-06-30
DK140947B (en) 1979-12-10
SE7709916L (en) 1978-03-04
NL182314B (en) 1987-09-16
YU227782A (en) 1983-02-28
YU40009B (en) 1985-06-30
PT66983A (en) 1977-10-01
GB1586504A (en) 1981-03-18
CH629829A5 (en) 1982-05-14
HU184769B (en) 1984-10-29
BE858354A (en) 1978-03-02
ES469573A1 (en) 1978-12-01
DK140947C (en) 1980-05-27
FI772599A7 (en) 1978-03-04
DE2738363C2 (en) 1988-01-14
LU78064A1 (en) 1978-10-17
PH14434A (en) 1981-07-16
IL52831A (en) 1982-04-30
GR73039B (en) 1984-01-26
NO145621C (en) 1982-04-28
NL7709585A (en) 1978-03-07
AR220320A1 (en) 1980-10-31
CH629827A5 (en) 1982-05-14
YU200977A (en) 1983-02-28
CH629828A5 (en) 1982-05-14
ES462076A1 (en) 1978-11-01
DE2738363A1 (en) 1978-03-16
FI57600C (en) 1980-09-10
FR2363580B1 (en) 1980-01-18
IE45671B1 (en) 1982-10-20
JPS5331655A (en) 1978-03-25
DK393277A (en) 1978-03-04
NO145621B (en) 1982-01-18
SE440783B (en) 1985-08-19
NO773057L (en) 1978-03-06
PT66983B (en) 1979-09-12
IT1085032B (en) 1985-05-28

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