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ES467100A1 - Phenyl-2-pyridinemethanol compounds and method for their production - Google Patents

Phenyl-2-pyridinemethanol compounds and method for their production

Info

Publication number
ES467100A1
ES467100A1 ES467100A ES467100A ES467100A1 ES 467100 A1 ES467100 A1 ES 467100A1 ES 467100 A ES467100 A ES 467100A ES 467100 A ES467100 A ES 467100A ES 467100 A1 ES467100 A1 ES 467100A1
Authority
ES
Spain
Prior art keywords
phenyl
cis
alpha
compounds
pyridinemethanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES467100A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/772,203 external-priority patent/US4112103A/en
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of ES467100A1 publication Critical patent/ES467100A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

(+,-)-cis- alpha -(3-(2,6-Dimethyl-1-piperidinyl)propyl)- alpha -phenyl-2-pyrid ylmethanol of the formula I and its acid addition salts. To prepare these compounds, pyridyllithium can be reacted with cis- gamma -(2,6-dimethylpiperidino)butyrophenone or cis-1-(3-lithiopropyl)-2,6-dimethylpiperidine with 2-benzoylpyridine. Pharmaceutical compositions comprising (+,-)-cis- alpha -(3-(2,6-dimethyl-1-piperidinyl)propyl)- alpha -phenyl-2-pyridylm ethanol and its acid addition salts can additionally be used for the treatment of cardiac arrhythmias.
ES467100A 1977-02-25 1978-02-17 Phenyl-2-pyridinemethanol compounds and method for their production Expired ES467100A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/772,203 US4112103A (en) 1976-04-15 1977-02-25 Antiarrhythmic (+,-)-cis-α-[3-(2,6-dimethyl-1-piperidinyl)propyl]-α-phenyl-2-pyridinemethanols

Publications (1)

Publication Number Publication Date
ES467100A1 true ES467100A1 (en) 1978-11-01

Family

ID=25094280

Family Applications (1)

Application Number Title Priority Date Filing Date
ES467100A Expired ES467100A1 (en) 1977-02-25 1978-02-17 Phenyl-2-pyridinemethanol compounds and method for their production

Country Status (11)

Country Link
JP (1) JPS53105479A (en)
AT (1) AT358040B (en)
BE (1) BE864033A (en)
CA (1) CA1096382A (en)
CH (1) CH635095A5 (en)
DE (1) DE2806654A1 (en)
DK (1) DK143229C (en)
ES (1) ES467100A1 (en)
FR (1) FR2381761A1 (en)
GB (1) GB1581096A (en)
PH (1) PH13125A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2818914B2 (en) * 1991-04-05 1998-10-30 シャープ株式会社 Multipurpose steam generator
CN116514770B (en) * 2023-05-09 2025-02-07 郑州大学 Method for efficiently preparing pyrmenol from 2-benzylpyridine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE757408A (en) * 1969-10-13 1971-04-13 Thomae Gmbh Dr K NEW TERTIARY BUTANOLS WITH BASIC CONSTITUENTS

Also Published As

Publication number Publication date
PH13125A (en) 1979-12-12
DE2806654A1 (en) 1978-08-31
DK143229C (en) 1981-11-30
FR2381761A1 (en) 1978-09-22
FR2381761B1 (en) 1982-03-26
AT358040B (en) 1980-08-11
CA1096382A (en) 1981-02-24
JPS53105479A (en) 1978-09-13
JPS6257632B2 (en) 1987-12-02
CH635095A5 (en) 1983-03-15
GB1581096A (en) 1980-12-10
BE864033A (en) 1978-06-16
DE2806654C2 (en) 1987-07-16
ATA117078A (en) 1980-01-15
DK143229B (en) 1981-07-27
DK73278A (en) 1978-08-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103