ES466245A1 - PROCEDURE FOR PREPARING ISOQUINOLINE DERIVATIVES - Google Patents
PROCEDURE FOR PREPARING ISOQUINOLINE DERIVATIVESInfo
- Publication number
- ES466245A1 ES466245A1 ES466245A ES466245A ES466245A1 ES 466245 A1 ES466245 A1 ES 466245A1 ES 466245 A ES466245 A ES 466245A ES 466245 A ES466245 A ES 466245A ES 466245 A1 ES466245 A1 ES 466245A1
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- isoquinoline derivatives
- preparing
- preparing isoquinoline
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000016571 aggressive behavior Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000000881 depressing effect Effects 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
The invention relates to a process for preparing compounds of the formula I, < IMAGE > in which R1, R2 and R3 have the meaning given in the description, by the elimination of water from the corresponding octahydro-6-ol derivatives. The compounds of the formula I possess the properties of inhibiting aggression and depressing the central nervous system.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH82077A CH630902A5 (en) | 1977-01-24 | 1977-01-24 | Process for preparing novel derivatives of 1,2,3,4,4a,10b-hexahydrobenzo(f)isoquinoline. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES466245A1 true ES466245A1 (en) | 1980-12-16 |
Family
ID=4195950
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466245A Expired ES466245A1 (en) | 1977-01-24 | 1978-01-23 | PROCEDURE FOR PREPARING ISOQUINOLINE DERIVATIVES |
| ES475587A Expired ES475587A1 (en) | 1977-01-24 | 1978-11-30 | 1,2,3,4,4a,10b-hexahydro-benz(f)isouqinolines |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES475587A Expired ES475587A1 (en) | 1977-01-24 | 1978-11-30 | 1,2,3,4,4a,10b-hexahydro-benz(f)isouqinolines |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5392778A (en) |
| AT (1) | AT367405B (en) |
| BE (1) | BE863215A (en) |
| CA (1) | CA1105468A (en) |
| CH (3) | CH630902A5 (en) |
| DE (1) | DE2801576A1 (en) |
| DK (1) | DK19278A (en) |
| ES (2) | ES466245A1 (en) |
| FI (1) | FI780130A7 (en) |
| FR (1) | FR2378015A1 (en) |
| GB (1) | GB1596170A (en) |
| IE (1) | IE46381B1 (en) |
| IL (1) | IL53869A (en) |
| IT (1) | IT7847687A0 (en) |
| NL (1) | NL7800719A (en) |
| NZ (1) | NZ186279A (en) |
| PH (1) | PH14194A (en) |
| PT (1) | PT67562B (en) |
| SE (1) | SE7800452L (en) |
| SU (1) | SU852172A3 (en) |
| ZA (1) | ZA78430B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8302361D0 (en) * | 1983-04-27 | 1983-04-27 | Astra Laekemedel Ab | NEW TRICYCLIC AMINES |
| US5294618A (en) * | 1989-07-28 | 1994-03-15 | Merck Sharp & Dohme Limited | Octahydrobenzisoquinoline derivatives as antipsychotic agents |
| GB8917333D0 (en) * | 1989-07-28 | 1989-09-13 | Merck Sharp & Dohme | Therapeutic agents |
| WO1993008166A1 (en) * | 1991-10-24 | 1993-04-29 | The Upjohn Company | Benzo-isoquinoline derivatives and analogs and their use in therapeutics |
| EP0539209A1 (en) * | 1991-10-24 | 1993-04-28 | The Upjohn Company | Benzo-isoquinoline derivatives and analogs and their use in therapeutics |
| TW357143B (en) * | 1995-07-07 | 1999-05-01 | Novartis Ag | Benzo[g]quinoline derivatives |
| AT407636B (en) * | 1999-07-09 | 2001-05-25 | Martin Dr Kratzel | Diels-Alder products of tetrahydropyridinedienes with naphthoquinones and their oxidation products, process for their preparation and their use for producing medicaments |
-
1977
- 1977-01-24 CH CH82077A patent/CH630902A5/en not_active IP Right Cessation
-
1978
- 1978-01-14 DE DE19782801576 patent/DE2801576A1/en not_active Withdrawn
- 1978-01-16 DK DK19278A patent/DK19278A/en not_active Application Discontinuation
- 1978-01-16 FI FI780130A patent/FI780130A7/en not_active Application Discontinuation
- 1978-01-16 SE SE7800452A patent/SE7800452L/en unknown
- 1978-01-18 IT IT7847687A patent/IT7847687A0/en unknown
- 1978-01-20 NZ NZ186279A patent/NZ186279A/en unknown
- 1978-01-20 NL NL7800719A patent/NL7800719A/en not_active Application Discontinuation
- 1978-01-23 CA CA295,458A patent/CA1105468A/en not_active Expired
- 1978-01-23 BE BE184555A patent/BE863215A/en not_active IP Right Cessation
- 1978-01-23 SU SU782571448A patent/SU852172A3/en active
- 1978-01-23 ES ES466245A patent/ES466245A1/en not_active Expired
- 1978-01-23 PT PT67562A patent/PT67562B/en unknown
- 1978-01-23 AT AT0045478A patent/AT367405B/en not_active IP Right Cessation
- 1978-01-23 IL IL53869A patent/IL53869A/en unknown
- 1978-01-23 PH PH20696A patent/PH14194A/en unknown
- 1978-01-23 IE IE151/78A patent/IE46381B1/en unknown
- 1978-01-23 GB GB2603/78A patent/GB1596170A/en not_active Expired
- 1978-01-23 JP JP534678A patent/JPS5392778A/en active Pending
- 1978-01-24 FR FR7801860A patent/FR2378015A1/en active Granted
- 1978-01-24 ZA ZA00780430A patent/ZA78430B/en unknown
- 1978-11-30 ES ES475587A patent/ES475587A1/en not_active Expired
-
1981
- 1981-03-20 CH CH190881A patent/CH630903A5/en not_active IP Right Cessation
- 1981-03-20 CH CH190981A patent/CH630904A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES475587A1 (en) | 1980-02-16 |
| CA1105468A (en) | 1981-07-21 |
| AU3265478A (en) | 1979-08-02 |
| PH14194A (en) | 1981-03-26 |
| PT67562B (en) | 1980-11-03 |
| SE7800452L (en) | 1978-07-25 |
| ZA78430B (en) | 1979-09-26 |
| FR2378015A1 (en) | 1978-08-18 |
| CH630904A5 (en) | 1982-07-15 |
| CH630902A5 (en) | 1982-07-15 |
| IE780151L (en) | 1978-07-24 |
| IE46381B1 (en) | 1983-05-18 |
| JPS5392778A (en) | 1978-08-15 |
| IT7847687A0 (en) | 1978-01-18 |
| DE2801576A1 (en) | 1978-07-27 |
| SU852172A3 (en) | 1981-07-30 |
| BE863215A (en) | 1978-07-24 |
| NL7800719A (en) | 1978-07-26 |
| IL53869A0 (en) | 1978-04-30 |
| ATA45478A (en) | 1981-11-15 |
| GB1596170A (en) | 1981-08-19 |
| FI780130A7 (en) | 1978-07-25 |
| PT67562A (en) | 1978-02-01 |
| CH630903A5 (en) | 1982-07-15 |
| DK19278A (en) | 1978-07-25 |
| AT367405B (en) | 1982-07-12 |
| NZ186279A (en) | 1980-05-27 |
| IL53869A (en) | 1981-05-20 |
| FR2378015B1 (en) | 1980-08-22 |
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