ES466005A2 - Analogues of prost-5,10,138-trienoic acid and process for preparing them - Google Patents
Analogues of prost-5,10,138-trienoic acid and process for preparing themInfo
- Publication number
- ES466005A2 ES466005A2 ES466005A ES466005A ES466005A2 ES 466005 A2 ES466005 A2 ES 466005A2 ES 466005 A ES466005 A ES 466005A ES 466005 A ES466005 A ES 466005A ES 466005 A2 ES466005 A2 ES 466005A2
- Authority
- ES
- Spain
- Prior art keywords
- compound
- main patent
- formula xix
- optionally
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 3
- 150000007513 acids Chemical class 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
Improvements introduced in the object of the main patent no. 439,465 filed on July 16, 1975 for: "Procedure for the preparation of new analog compounds of prostanoic acids that do not occur in nature", characterized in that a compound of the formula is prepared I of main patent no. 439,465, in which R4 and R5 jointly signify oxygen, according to steps a), or b1) to b8), or c1) to C8) of the process of claim 3 of the main patent, the compound obtained is reacted with an acylating agent, and optionally the compound of formula XIX obtained is reduced to form a compound of formula XIX, in which one of the radicals R4 and R5 signifies a hydroxyl group and the other signifies hydrogen, and optionally a free acid of formula XIX is transformed according to usual procedures, into a physiologically compatible salt or into an ester. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772702368 DE2702368A1 (en) | 1977-01-21 | 1977-01-21 | NEW PROSTAGLANDIN ANALOGS AND METHOD FOR THEIR PRODUCTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES466005A2 true ES466005A2 (en) | 1978-10-01 |
Family
ID=5999194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466005A Expired ES466005A2 (en) | 1977-01-21 | 1978-01-16 | Analogues of prost-5,10,138-trienoic acid and process for preparing them |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5392742A (en) |
| AU (1) | AU3256178A (en) |
| BE (1) | BE863206R (en) |
| DE (1) | DE2702368A1 (en) |
| DK (1) | DK29378A (en) |
| ES (1) | ES466005A2 (en) |
| FI (1) | FI780169A7 (en) |
| FR (1) | FR2378008A2 (en) |
| GB (1) | GB1577991A (en) |
| LU (1) | LU78916A1 (en) |
| NL (1) | NL7714520A (en) |
| NO (1) | NO780226L (en) |
| SE (1) | SE7800689L (en) |
| ZA (1) | ZA78368B (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4094899A (en) * | 1972-06-02 | 1978-06-13 | Pfizer Inc. | Oxaprostaglandins |
| GB1545633A (en) * | 1975-02-24 | 1979-05-10 | American Cyanamid Co | 11-deoxy substituted prostaglandins of the e and f series |
-
1977
- 1977-01-21 DE DE19772702368 patent/DE2702368A1/en active Pending
- 1977-12-29 NL NL7714520A patent/NL7714520A/en not_active Application Discontinuation
-
1978
- 1978-01-16 ES ES466005A patent/ES466005A2/en not_active Expired
- 1978-01-19 FI FI780169A patent/FI780169A7/en not_active Application Discontinuation
- 1978-01-19 AU AU32561/78A patent/AU3256178A/en active Pending
- 1978-01-19 LU LU78916A patent/LU78916A1/en unknown
- 1978-01-19 SE SE7800689A patent/SE7800689L/en unknown
- 1978-01-20 JP JP573278A patent/JPS5392742A/en active Pending
- 1978-01-20 NO NO780226A patent/NO780226L/en unknown
- 1978-01-20 ZA ZA00780368A patent/ZA78368B/en unknown
- 1978-01-20 DK DK29378A patent/DK29378A/en not_active Application Discontinuation
- 1978-01-23 GB GB2609/78A patent/GB1577991A/en not_active Expired
- 1978-01-23 FR FR7801789A patent/FR2378008A2/en active Pending
- 1978-01-23 BE BE184546A patent/BE863206R/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU3256178A (en) | 1979-07-26 |
| LU78916A1 (en) | 1978-09-28 |
| SE7800689L (en) | 1978-07-22 |
| DK29378A (en) | 1978-07-22 |
| JPS5392742A (en) | 1978-08-15 |
| GB1577991A (en) | 1980-10-29 |
| ZA78368B (en) | 1979-01-31 |
| DE2702368A1 (en) | 1978-08-03 |
| FI780169A7 (en) | 1978-07-22 |
| NO780226L (en) | 1978-07-24 |
| FR2378008A2 (en) | 1978-08-18 |
| NL7714520A (en) | 1978-07-25 |
| BE863206R (en) | 1978-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD2A | Announcement of lapse in spain |
Effective date: 20170706 |