ES459838A1 - Un procedimiento para preparar cloruro de sulfinilo. - Google Patents
Un procedimiento para preparar cloruro de sulfinilo.Info
- Publication number
- ES459838A1 ES459838A1 ES459838A ES459838A ES459838A1 ES 459838 A1 ES459838 A1 ES 459838A1 ES 459838 A ES459838 A ES 459838A ES 459838 A ES459838 A ES 459838A ES 459838 A1 ES459838 A1 ES 459838A1
- Authority
- ES
- Spain
- Prior art keywords
- preparing
- exomethylenecepham sulfoxide
- sulfoxide
- penicillin sulfoxides
- exomethylenecepham
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 penicillin sulfoxides Chemical class 0.000 title abstract 2
- 150000003462 sulfoxides Chemical class 0.000 title abstract 2
- 229930182555 Penicillin Natural products 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940049954 penicillin Drugs 0.000 title 1
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 abstract 3
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 abstract 3
- 239000000292 calcium oxide Substances 0.000 abstract 3
- KDXFMMHNGFNJFA-UHFFFAOYSA-N 4-oxoazetidine-2-sulfinyl chloride Chemical compound ClS(=O)C1CC(=O)N1 KDXFMMHNGFNJFA-UHFFFAOYSA-N 0.000 abstract 1
- 229910021627 Tin(IV) chloride Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012084 conversion product Substances 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un procedimiento para preparar cloruro de sulfinilo de fórmula (Ver fórmula 1), haciendo reaccionar un sulfóxido de penicilina de fórmula (Ver fórmula 2), con un agente de halogenación de N-cloro a una temperatura de aproximadamente 75ºC a aproximadamente 135ºC en un solvente inerte, bajo condiciones anhidras y en presencia de un compuesto epóxido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/696,674 US4075203A (en) | 1976-06-16 | 1976-06-16 | Process for preparing a 3-exomethylenecepham sulfoxide from penicillin sulfoxides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES459838A1 true ES459838A1 (es) | 1978-04-01 |
Family
ID=24798089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES459838A Expired ES459838A1 (es) | 1976-06-16 | 1977-06-16 | Un procedimiento para preparar cloruro de sulfinilo. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4075203A (es) |
| JP (1) | JPS6043339B2 (es) |
| AR (1) | AR219926A1 (es) |
| AT (1) | AT352138B (es) |
| AU (1) | AU508748B2 (es) |
| BE (1) | BE855694A (es) |
| CA (1) | CA1083579A (es) |
| CH (1) | CH627161A5 (es) |
| CS (1) | CS198246B2 (es) |
| DD (1) | DD131018A5 (es) |
| DE (1) | DE2726394A1 (es) |
| DK (1) | DK264577A (es) |
| ES (1) | ES459838A1 (es) |
| FR (1) | FR2355005A1 (es) |
| GB (1) | GB1584105A (es) |
| HU (1) | HU179966B (es) |
| IE (1) | IE45195B1 (es) |
| IL (1) | IL52117A (es) |
| NL (1) | NL189609C (es) |
| NZ (1) | NZ184136A (es) |
| PH (1) | PH13001A (es) |
| PL (1) | PL103103B1 (es) |
| PT (1) | PT66642B (es) |
| RO (1) | RO71066A (es) |
| SE (1) | SE438329B (es) |
| YU (1) | YU143177A (es) |
| ZA (1) | ZA772907B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4138553A (en) * | 1976-11-11 | 1979-02-06 | Teijin Limited | 3-Methylene cephalosporanic acid derivatives and process for preparation thereof |
| US4159272A (en) * | 1977-09-01 | 1979-06-26 | Eli Lilly And Company | Process for 2-chlorosulfinylazetidin-4-ones |
| US4289695A (en) * | 1978-11-13 | 1981-09-15 | Eli Lilly And Company | Process for preparing 2-chlorosulfinylazetidinones |
| US5126446A (en) * | 1991-01-04 | 1992-06-30 | Eli Lilly And Company | Process for 3-exomethylenecepham sulfoxide esters |
| US5350845A (en) * | 1992-04-08 | 1994-09-27 | Eli Lilly And Company | Process for preparing 7-substituted-amino-3-hydroxy-3-cephem-4-protected carboxy-sulfoxide esters |
| US5347000A (en) * | 1992-11-05 | 1994-09-13 | Ranbaxy Laboratories Ltd. | Process for the preparation of 2-chlorosulfinylazetidinone |
| US5604222A (en) * | 1993-12-27 | 1997-02-18 | Lupin Laboratories, Ltd. | Method for the preparation of 2-chloro sulfinyl azetidinones |
| US5578721A (en) * | 1994-07-11 | 1996-11-26 | Lupin Laboratories Limited | Process for preparation of 3-exomethylene cepham sulfoxide esters |
| US6116362A (en) * | 1998-07-09 | 2000-09-12 | Case Corporation | Articulated vehicle |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS551272B2 (es) * | 1972-04-14 | 1980-01-12 | ||
| US3843682A (en) * | 1972-05-15 | 1974-10-22 | Lilly Co Eli | 2-chlorosulfinyl-3-imido-azetedin-4-ones |
| GB1442785A (en) * | 1972-12-09 | 1976-07-14 | Nikken Chemicals Co Ltd | Desacetoxy ceaphalosporanic acids |
| NL7411505A (nl) * | 1973-09-06 | 1975-03-10 | Rhone Poulenc Sa | Werkwijze voor de bereiding en toepassing van nieuwe 7-trichlooraceetamido-3-desacetoxy-cefa- losporanzuurpreparaten. |
| CA1069126A (en) * | 1974-12-24 | 1980-01-01 | Eli Lilly And Company | Sulfinyl halides and their preparation from penicillin sulfoxides |
-
1976
- 1976-06-16 US US05/696,674 patent/US4075203A/en not_active Expired - Lifetime
-
1977
- 1977-05-13 CA CA278,389A patent/CA1083579A/en not_active Expired
- 1977-05-16 ZA ZA00772907A patent/ZA772907B/xx unknown
- 1977-05-16 IE IE996/77A patent/IE45195B1/en not_active IP Right Cessation
- 1977-05-18 NZ NZ184136A patent/NZ184136A/xx unknown
- 1977-05-18 IL IL52117A patent/IL52117A/xx unknown
- 1977-05-24 AU AU25427/77A patent/AU508748B2/en not_active Expired
- 1977-06-06 PT PT66642A patent/PT66642B/pt unknown
- 1977-06-09 GB GB24262/77A patent/GB1584105A/en not_active Expired
- 1977-06-09 YU YU01431/77A patent/YU143177A/xx unknown
- 1977-06-10 PH PH19871A patent/PH13001A/en unknown
- 1977-06-10 DE DE19772726394 patent/DE2726394A1/de active Granted
- 1977-06-15 NL NLAANVRAGE7706604,A patent/NL189609C/xx not_active IP Right Cessation
- 1977-06-15 AT AT423777A patent/AT352138B/de not_active IP Right Cessation
- 1977-06-15 JP JP52071548A patent/JPS6043339B2/ja not_active Expired
- 1977-06-15 HU HU77EI747A patent/HU179966B/hu unknown
- 1977-06-15 BE BE1008193A patent/BE855694A/xx not_active IP Right Cessation
- 1977-06-15 PL PL1977198878A patent/PL103103B1/pl unknown
- 1977-06-15 SE SE7706948A patent/SE438329B/xx not_active IP Right Cessation
- 1977-06-15 CH CH737877A patent/CH627161A5/de not_active IP Right Cessation
- 1977-06-15 CS CS773959A patent/CS198246B2/cs unknown
- 1977-06-15 AR AR268068A patent/AR219926A1/es active
- 1977-06-15 RO RO7790694A patent/RO71066A/ro unknown
- 1977-06-15 DK DK264577A patent/DK264577A/da not_active Application Discontinuation
- 1977-06-16 ES ES459838A patent/ES459838A1/es not_active Expired
- 1977-06-16 FR FR7718551A patent/FR2355005A1/fr active Granted
- 1977-06-16 DD DD7700199521A patent/DD131018A5/xx unknown
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